The relationships among the skeletal muscle mass index, cardiorespiratory fitness and the prevalence of coronary artery disease in the elderly population

2020 ◽  
Vol 90 ◽  
pp. 104107
Author(s):  
Wuyang He ◽  
Nanxin Peng ◽  
Qingwei Chen ◽  
Tingting Xiang ◽  
Peng Wang ◽  
...  
2020 ◽  
Vol 21 (17) ◽  
pp. 6263
Author(s):  
Sergey G. Kozlov ◽  
Olga V. Chernova ◽  
Elena V. Gerasimova ◽  
Ekaterina A. Ivanova ◽  
Alexander N. Orekhov

Efficient diagnostic approaches to detect coronary artery disease (CAD) in elderly patients are necessary to ensure optimal and timely treatment. The population of suspected CAD patients older than 70 years is especially vulnerable and constantly growing. Finding the optimal diagnostic approach is challenging due to certain features of this population, such as high prevalence of comorbidities, existing contraindications to exercise tests or cognitive decline, which hinders correct assessment of the patient’s situation. Moreover, some symptoms of CAD can have variable significance in the elderly compared to younger adult groups. In this review, we present current recommendations of the United States (US) and European cardiologists’ associations and discuss their applicability for diagnostics in the elderly population. Exercise electrocardiogram (ECG) and exercise stress echocardiography (SE) tests are not feasible for a substantial proportion of elderly patients. Coronary computed tomography angiography (CTA) appears to be an attractive alternative for such patients, but is not universally applicable; for instance, it is problematic in patients with significant calcification of the vessels. Moreover, more studies are needed to compare the results delivered by CTA to those of other diagnostic methods. Future efforts should be focused on comparative studies to better understand the limits and advantages of different diagnostic methods and their combinations. It is possible that some of the currently used diagnostic criteria could be improved to better accommodate the needs of the elderly population.


2013 ◽  
Vol 85 (2) ◽  
pp. 167 ◽  
Author(s):  
Hee Won Jung ◽  
Sun Wook Kim ◽  
Ho Jun Chin ◽  
Cheol Ho Kim ◽  
Kwang Il Kim

2022 ◽  
Vol 270 ◽  
pp. 444-454
Author(s):  
Nicholas R Hess ◽  
Arman Kilic ◽  
Yisi Wang ◽  
Pyongsoo D Yoon ◽  
Forozan Navid ◽  
...  

Heart ◽  
2014 ◽  
Vol 101 (Suppl 1) ◽  
pp. A22.3-A23
Author(s):  
T Liu ◽  
J Zhang ◽  
Y Chen ◽  
X Feng ◽  
L Wang ◽  
...  

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
H. Alemán-Mateo ◽  
Roxana E. Ruiz Valenzuela

Background and Objectives. Skeletal muscle and skeletal muscle indices in young adults from developing countries are sparse. Indices and the corresponding cut-off points can be a reference for diagnoses of sarcopenia. This study assessed skeletal muscle using dual-energy X-ray absorptiometry (DXA) in healthy male and female subjects aged 20–40 years and compared their appendicular skeletal muscle mass (ASM) and total-body skeletal muscle (TBSM) indices using certain cut-off points published in the literature.Methods. A sample of 216 healthy adults men and women from northwest Mexico was included. Body composition was assessed by DXA and several published DXA-derived skeletal muscle indices were compared.Results. Both, ASM and TBSM were higher in men compared to the women group (23.0 ± 3.4 versus 15.9 ± 1.6 kg;P<0.05and 26.5 ± 4.1 versus 16.9 ± 1.9 kg;P<0.05, resp.). These differences were also valid for both indices. When derived cut-off points were compared with the most reported indices, significant differences were found.Interpretation and Conclusion. Published cut-off points from Caucasians are higher than cut-off point derived in this sample of Mexican subjects. The new DXA-derived cut-off points for ASM proposed herein may improve diagnoses of sarcopenia in the geriatric Mexican population.


2019 ◽  
Vol 8 (5) ◽  
pp. 712 ◽  
Author(s):  
Dong Oh Kang ◽  
So Yeon Park ◽  
Byoung Geol Choi ◽  
Jin Oh Na ◽  
Cheol Ung Choi ◽  
...  

The impact of sarcopenia on atherosclerotic cardiovascular disease remains unclear. We aimed to investigate the prognostic impact of sarcopenia on coronary artery disease (CAD). A total of 475 patients with CAD who underwent successful percutaneous coronary intervention (PCI) and computed tomography (CT) were enrolled. The cross-sectional area of skeletal muscle at the first lumbar (L1) vertebral level was measured, and sex-specific cut-off values of L1 skeletal muscle index (L1 SMI; male <31.00 cm2/m2, female <25.00 cm2/m2) were obtained. The primary outcome was 3-year all-cause mortality and the secondary outcome was 3-year major adverse cardiovascular events (MACEs). Low L1 SMI was present in 141 (29.7%) of 475 patients. The incidence of all-cause mortality (23.7% vs. 5.9%, p < 0.001) and MACEs (39.6% vs. 11.8%, p < 0.001) was significantly higher in patients with low L1 SMI than in those with high L1 SMI. In multivariate analysis, low L1 SMI was an independent predictor of higher risk of all-cause mortality (hazard ratio (HR): 4.07; 95% confidence interval (CI): 1.95–8.45; p < 0.001) and MACEs (HR: 3.76; 95% CI: 2.27–6.23; p < 0.001). These findings remained consistent after propensity score-matched analysis with 91 patient pairs (C-statistic = 0.848). CT-diagnosed low skeletal muscle mass is a powerful predictor of adverse outcomes in patients with CAD undergoing PCI.


Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1931-P
Author(s):  
KATHERINE V. WILLIAMS ◽  
CHRISTINA M. SHAY ◽  
JULIE PRICE ◽  
TREVOR J. ORCHARD ◽  
DAVID KELLEY

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