F-spondin negatively regulates dental follicle differentiation through the inhibition of TGF-β activity

Abstract Background ADAMTS expression can be associated with several inflammatory processes, and has been correlated with tumorigenesis of some neoplasms, but its participation in the development of periapical lesions has not been investigated. Therefore, our objective was to verify the expression of ADAMTS-1, versican and pEGFR in Periapical Granuloma (PG) and in the Radicular Cyst (RC) since they are the most common lesions of the periapex. Methods 25 samples of RC and 10 of PG were used. As a control, 10 samples of inflammatory fibrous hyperplasia (IFH) and 10 of dental follicle (DF) were used. The expression of these proteins was investigated using immunohistochemistry. Results In the epithelium of RC, IFH and DF, the expression of ADAMTS-1 was greater in DF than in RC (p < .001). Versicano showed greater expression in IFH than in RC, DF than in RC (p < .001). pEGFR showed greater expression in IFH and RC than in DF (p < .01 and p < .05, respectively). In connective tissue, ADAMTS-1 expression was greater in PG and RC than in IFH and DF (p < .001). Versicano showed greater expression in PG, RC and IFH compared to DF (p < .001). In pEGFR there was a higher expression in PG when compared to RC, IFH and DF (p < .001). Greater immunostaining occurred in the RC than in the DF (p < .001). Conclusions Our results suggest that the studied proteins may participate in the pathogenesis of PG and RC, through the interaction of these proteins, in the remodeling of the ECM (versican) by ADAMTS-1, producing bioactive fragments, which could activate EGFR, contributing to the formation, growth and maintenance of injuries.

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The AKT signaling pathway sustains the osteogenic differentiation in human dental follicle cells

Molecular and Cellular Biochemistry ◽

10.1007/s11010-015-2437-8 ◽

2015 ◽

Vol 406 (1-2) ◽

pp. 199-204 ◽

Cited By ~ 6

Author(s):

S. Viale-Bouroncle ◽

C. Klingelhöffer ◽

T. Ettl ◽

C. Morsczeck

Keyword(s):

Osteogenic Differentiation ◽

Signaling Pathway ◽

Akt Signaling ◽

Follicle Cells ◽

Dental Follicle ◽

Akt Signaling Pathway ◽

Dental Follicle Cells

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Monitoring enlarged dental follicles: case report and literature review of an unusual presentation of a unicystic ameloblastoma

Dental Update ◽

10.12968/denu.2021.48.7.564 ◽

2021 ◽

Vol 48 (7) ◽

pp. 564-569

Author(s):

Lily Long ◽

Jasveen Matharu ◽

Sunil Sah

Keyword(s):

Case Report ◽

Literature Review ◽

Pathological Fracture ◽

Incidental Finding ◽

Third Molar ◽

Dental Follicle ◽

Odontogenic Tumour ◽

Unicystic Ameloblastoma ◽

Dental Practitioners ◽

Unerupted Teeth

An ameloblastoma is a benign, yet locally aggressive odontogenic tumour. The vast majority (80%) of ameloblastomas arise in the mandible, and unicystic ameloblastomas are commonly found in relation to an unerupted lower third molar. We present the case of a 39-year-old patient with an incidental finding of an enlarged dental follicle around an unerupted lower third molar that progressed to an extensive unicystic ameloblastoma. This ameloblastoma was decompressed and marsupialized before enucleation to reduce the risk of pathological fracture due to the extensive size of the tumour. CPD/Clinical Relevance: The case is relevant to general dental practitioners when considering monitoring dental follicles of unerupted teeth because the enlarged dental follicle described progressed to an extensive odontogenic tumour.

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