Should we target increased physical activity or less sedentary behavior in the battle against cardiovascular disease risk development?

2020 ◽  
Vol 311 ◽  
pp. 107-115
Author(s):  
Peter T. Katzmarzyk ◽  
Robert Ross ◽  
Steven N. Blair ◽  
Jean-Pierre Després
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Sedentary Behavior ◽  
Disease Risk ◽  
Cardiovascular Disease Risk

scholarly journals Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study

2021 ◽  
Author(s):  
Martin Bahls ◽  
Michael F. Leitzmann ◽  
André Karch ◽  
Alexander Teumer ◽  
Marcus Dörr ◽  
...  
Keyword(s):  
Physical Activity ◽  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Ischemic Stroke ◽  
Coronary Artery ◽  
Sedentary Behavior ◽  
Mendelian Randomization ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Artery Disease

Abstract Aims Observational evidence suggests that physical activity (PA) is inversely and sedentarism positively related with cardiovascular disease risk. We performed a two-sample Mendelian randomization (MR) analysis to examine whether genetically predicted PA and sedentary behavior are related to coronary artery disease, myocardial infarction, and ischemic stroke. Methods and results We used single nucleotide polymorphisms (SNPs) associated with self-reported moderate to vigorous PA (n = 17), accelerometer based PA (n = 7) and accelerometer fraction of accelerations > 425 milli-gravities (n = 7) as well as sedentary behavior (n = 6) in the UK Biobank as instrumental variables in a two sample MR approach to assess whether these exposures are related to coronary artery disease and myocardial infarction in the CARDIoGRAMplusC4D genome-wide association study (GWAS) or ischemic stroke in the MEGASTROKE GWAS. The study population included 42,096 cases of coronary artery disease (99,121 controls), 27,509 cases of myocardial infarction (99,121 controls), and 34,217 cases of ischemic stroke (404,630 controls). We found no associations between genetically predicted self-reported moderate to vigorous PA, accelerometer-based PA or accelerometer fraction of accelerations > 425 milli-gravities as well as sedentary behavior with coronary artery disease, myocardial infarction, and ischemic stroke. Conclusions These results do not support a causal relationship between PA and sedentary behavior with risk of coronary artery disease, myocardial infarction, and ischemic stroke. Hence, previous observational studies may have been biased. Graphic abstract

scholarly journals Physical Activity and Cardiovascular Disease Risk Profile in Women

1997 ◽  
Vol 146 (4) ◽  
pp. 322-328 ◽  
Author(s):  
M. A. Pols ◽  
P. H. M. Peeters ◽  
J. W. R. Twisk ◽  
H. C. G. Kemper ◽  
D. E. Grobbee
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Risk Profile

scholarly journals Habitual physical activity is not associated with lower cardiovascular risk profile or higher aerobic fitness

2020 ◽  
pp. 1-6
Author(s):  
Denis Fabrício Valério ◽  
Arthur Fernandes Gáspari ◽  
Giovana Vergínea de Souza ◽  
Cleiton Augusto Libardi ◽  
Claudia Regina Cavaglieri ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Aerobic Fitness ◽  
Physical Inactivity ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Risk Profile ◽  
Cardiovascular Risk Profile ◽  
Vo2 Max

Introduction: Physical inactivity is considered as one of the factors to increase the risk of developing cardiovascular diseases (CVDs) and decrease aerobic fitness mainly in middle-age. Increased habitual physical activity (HPA) is one of the strategies recommended to reduce physical inactivity. However, it is not known whether middle-age individuals who exclusively perform greater amount of HPA have greater aerobic fitness and / or a lower risk of CVDs. Objective: Verify the association between HPA with the risk of CVDs and aerobic fitness in individuals who only perform HPA. Method: We selected 89 male volunteers, age: 47.4 ± 5.06 years, who did not practice systemized physical training. Our measurements were: HPA by the International Physical Activity Questionnaire and Baecke questionnaires, the aerobic fitness by direct assessment of maximal oxygen consumption (VO2 máx) and the risk of developing cardiovascular disease by the score calculation of General Cardiovascular Risk Profile from Framingham Study. Results: There was no correlation of the HPA level with cardiovascular risk factors, general cardiovascular disease risk and VO2 máx. Moreover, no difference was found between the categorical groups of the IPAQ questionnaire and between the groups, “clusters”, calculated from the Baecke questionnaire scores for the variables of cardiovascular risk, general cardiovascular disease risk and VO2 máx. Conclusion: This study have found that the HPA level of middle-aged men is not associated with lower cardiovascular risk profile or higher aerobic fitness, suggesting that only increase HPA may not be enough to promote beneficial adaptations in aerobic fitness and improve risk profile for CVDs. These results may be related to low volume and intensity of HPA, which reinforces the importance of performing physical training with control of these variables for health promotion.

scholarly journals Sedentarism and chronic disease risk in COVID 19 lockdown – a scoping review

2020 ◽  
pp. 003693302094633
Author(s):  
Baskaran Chandrasekaran ◽  
Thiru Balaji Ganesan
Keyword(s):  
Mental Health ◽  
Physical Activity ◽  
Cardiovascular Disease ◽  
Chronic Disease ◽  
Sedentary Behaviour ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Chronic Disease Risk ◽  
Critical Measure ◽  
Obesity Hypertension

Background & Aims Though viewed as a critical measure to prevent the spread of the virus, a prolonged homestay may result in unfavourable sedentary behaviour and chronic disease risk. This systematic review focuses on sedentary behaviour resulting from this quarantine period which may elevate the cardiovascular disease risk, obesity, hypertension, cancer and mental health illness. Methods Evidence of breaking sedentary behaviour and global recommendations were investigated. Potential unanswered questions regarding sedentary behaviour and physical activity during lockdown were explored. Results Five systematic reviews and six prospective trials explored the effect of sedentarism affecting chronic disease through potential pathophysiological mechanisms. Sedentary behaviour especially prolonged sitting is found to be a pleiotropic risk factor with altered energy expenditure, adipogenic signalling, immunomodulation, autonomic stability and hormonal dysregulation perpetuating underlying chronic diseases such as obesity, cardiovascular disease, cancer and mental health disorders. Conclusion Breaking sitting and physical activity are found to reverse the adverse effects associated with excessive sitting during the lockdown.

scholarly journals Physical activity, stress, and cardiovascular disease risk: HCHS/SOL Sociocultural Ancillary Study

2020 ◽  
Vol 20 ◽  
pp. 101190
Author(s):  
Priscilla M. Vásquez ◽  
Ramon A. Durazo-Arvizu ◽  
David X. Marquez ◽  
Maria Argos ◽  
Melissa Lamar ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Ancillary Study
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