Abstract
Background: Triglyceride glucose (TyG) index is considered a reliable alternative marker of insulin resistance and an independent predictor of cardiovascular outcomes. However, the prognostic value of TyG index in patients with type 2 diabetes mellitus (T2DM) and acute myocardial infarction (AMI) remains unclear. Methods: A total of 1932 consecutive patients with T2DM and AMI were enrolled in this study. Patients were divided into tertiles according to their TyG index levels. The incidences of major adverse cardiac and cerebral events (MACCEs), including all-cause death, non-fatal MI, non-fatal stroke, cardiac rehospitalization and revascularization, were recorded. The TyG index was calculated as the ln [fasting triglycerides (mg/dL) ×fasting plasma glucose (mg/dL)/2].Results: Kaplan-Meier curves showed that the incidences of cardiac rehospitalization (p=0.001), revascularization (p<0.001) and composite MACCEs (p=0.027) increased with TyG index tertiles. Multivariable Cox regression models revealed that the TyG index was positively associated with all-cause death, cardiovascular death, cardiac rehospitalization, revascularization and composite MACCEs. The addition of TyG index to a baseline risk model had an incremental effect on the predictive value for composite MACCEs [AUC: 0.663 vs. 0.708, p<0.001].Conclusions: The TyG index was significantly associated with MACCEs, suggesting that the TyG index may be a valid marker for risk stratification and prognosis in patients with T2DM and AMI.Trial registration: retrospectively registered
Diagnostic value of carotid artery ultrasound and hypersensitive C-reactive protein in Type 2 diabetes mellitus patients with acute myocardial infarction in Chinese population
