Socioeconomic status and clinical stage of patients presenting for treatment of chronic venous disease

Objective: To study the microcirculation of the skin of the leg in patients with chronic venous disease of the lower limb, and to assess the effect of compression treatment. Patients and Methods: Patients were recruited from the vascular clinic and investigated by direct capillary pressure, transcutaneous oxygen tension, intravital video capillaroscopy and fluorescence video microscopy. The microcirculation was observed over the healing period in patients with venous leg ulcers. The effects of compression therapy on microcirculatory changes were studied in patients with Widmer stage I and II chronic venous disease. Results: In patients suffering from lipodermatosclerosis or venous leg ulcers retrograde pressure waves were detected in the nutritive capillaries of the skin by the ‘servo nulling’ pressure measurement during simulated calf muscle contraction. A close correlation was found between the degree of trophic skin change and the microangiopathy observed. Healing of venous ulcers occurred only if the cutaneous microcirculation in the ulcer area improved. Capillary density in base of the ulcer and at the border predicted venous ulcer healing. Conclusions: Cutaneous microangiopathy precedes the development of trophic skin alterations due to chronic venous disease and microcirculatory changes are closely related to the clinical stage of the disease as well as to the outcome of treatment.

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The method for determining the degree of venous pathology depending on the index of erythrocytes deformability

Medical Science And Education Of Ural ◽

10.36361/1814-8999-2021-22-1-36-40 ◽

2021 ◽

Vol 22 (1) ◽

pp. 36-40

Author(s):

L. N. Komarova ◽

◽

K. U. Nabiyeva ◽

M. A. Kisileva ◽

N. V. Bruvskaya ◽

...

Keyword(s):

Varicose Veins ◽

Clinical Stage ◽

Venous Blood ◽

Lower Extremities ◽

Blood Parameters ◽

Chronic Venous Disease ◽

Venous Disease ◽

Clinical Form ◽

Venous Outflow ◽

Deformability Of Erythrocytes

Aim. To study the ability of erythrocytes to deformability in patients with chronic diseases of the veins of the lower extremities. Materials and methods. From March to July 2019, we conducted a study of the deformability of erythrocytes in 271 railway workers using the method of laser diffractometry. The study of blood samples was carried out at the Department of Human and Animal Anatomy and Physiology of the Institute of Biology. At the same time, there were 182 people with varicose veins of the lower extremities, which was confirmed by the data of ultrasound angioscanning of the veins. Results. Studying the deformability of red blood cells of venous blood in patients with chronic venous disease of the lower extremities, we have identified certain patterns. With the increase in the clinical stage (form) of the disease of varicose veins of the lower extremities, the deformability of erythrocytes decreases, the deterioration of blood parameters is determined, which is confirmed by the data of a small coagulogram and a general blood test. The deformability index in the range from 0.12 to 0.42 indicates a violation of venous outflow in the subcutaneous venous system of the lower extremities, the deformability index from 0.42 and above indicates the presence of a thrombotic process in the deep veins of the lower extremities. Conclusion. With an increase in the erythrocyte deformability index, venous insufficiency increases, and venous outflow worsens. The higher the severity of the disease (clinical form C4-6), the lower the deformability of erythrocytes. In patients with VBLK, as the disease progresses, there is a decrease in the deformability of erythrocytes (i. e., in patients with the clinical form according to CEAP C2-3, the deformability is higher than in C3-4; in patients with C3-4, it is higher than in С4-5 … etc.).

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Duffy antigen / receptor for chemokines correlates with inflammatory reaction in rats with venous hypertension: implication for the pathogenesis of primary chronic venous disease

VASA ◽

10.1024/0301-1526/a000327 ◽

2014 ◽

Vol 43 (1) ◽

pp. 47-54 ◽

Cited By ~ 1

Author(s):

Weibin Huang ◽

Weiwei Qin ◽

Lei Lv ◽

Haoyv Deng ◽

Hao Zhang ◽

...

Keyword(s):

Mononuclear Cells ◽

Early Stage ◽

Antigen Receptor ◽

Venous Hypertension ◽

Skin Tissue ◽

Chronic Venous Disease ◽

Venous Disease ◽

Dependent Manner ◽

Time Points ◽

Duffy Antigen

Background: Duffy antigen / receptor for chemokines (DARC) possesses high affinity for several chemokine subgroups of CC and CXC. Although DARC has been shown to play a role in many inflammatory diseases, its effect on chronic venous disease (CVD) remains unidentified. We explored whether the expression of DARC in skin tissue was activated under venous hypertension as well as the relationships between DARC and inflammation. Materials and methods: The inflammation in a rat model of venous hypertension caused by a femoral arterial-venous fistula (AVF) was studied. At specified intervals the pressure in the femoral veins was recorded within 42 days. Hindlimb skin specimens were harvested at different time points. The expressions of DARC, interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1) in skin tissue were examined. Mononuclear cells infiltrated in skin tissue were detected. Results: Femoral venous pressures in AVF groups increased significantly at different time points (P < 0.01). DARC was expressed in skin tissue and its expression level increased significantly in AVF groups from the 7nd day on and was enhanced in a time-dependent manner within 42 days (P < 0.05). Meanwhile, both MCP-1 and IL-8 had higher levels, accompanied by increased mononuclear cells infiltrating into skin tissue (P < 0.05). Conclusions: A rat AVF model which can maintain venous hypertension for at least 42 days is competent for researching the pathogenesis of CVD. DARC, which plays a role in the inflammation of skin tissue under venous hypertension, may become a new molecular target for diagnosis and treatment of CVD at a very early stage.

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Endovenous stenting in chronic venous disease secondary to iliac vein obstruction

Italian Journal of Vascular and Endovascular Surgery ◽

10.23736/s1824-4777.18.01398-0 ◽

2019 ◽

Vol 26 (2) ◽

Author(s):

Mohamed A. Taha ◽

Tristan Lane ◽

Joseph Shalhoub ◽

Alun H. Davies

Keyword(s):

Iliac Vein ◽

Chronic Venous Disease ◽

Venous Disease

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Nédemax® Mese (Leucoselect®, Lymphaselect®, Bromelain) in the treatment of chronic venous disease: a multicenter, observational study

Acta Phlebologica ◽

10.23736/s1593-232x.19.00437-5 ◽

2019 ◽

Vol 20 (1) ◽

Author(s):

Rino Albrigo ◽

Cinzia Andreoni ◽

Gaetano Anello ◽

Maria G. Barboni ◽

Elena Barzaghi ◽

...

Keyword(s):

Observational Study ◽

Chronic Venous Disease ◽

Venous Disease ◽

Multicenter Observational Study

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3D modeling of the vascular system

Journal of Theoretical and Applied Vascular Research ◽

10.24019/jtavr.8 ◽

2016 ◽

Vol 1 (1) ◽

pp. 51-58 ◽

Cited By ~ 1

Author(s):

Jean François Uhl ◽

Maxime Chahim ◽

François Cros ◽

Amina Ouchene ◽

◽

...

Keyword(s):

Augmented Reality ◽

3D Modeling ◽

Vascular System ◽

Arterial System ◽

Chronic Venous Disease ◽

Venous Disease ◽

Software Products ◽

Operative Planning ◽

Morphological Modeling ◽

Pre Treatment

The 3D modeling of the vascular system could be achieved in different ways: In the venous location, the morphological modeling by MSCT venography is used to image the venous system: this morphological modeling tool accurately investigates the 3D morphology of the venous network of our patients with chronic venous disease. It is also a fine educational tool for students who learn venous anatomy, the most complex of the human body. Another kind of modeling (mathematical modeling) is used to simulate the venous functions, and virtually tests the efficacy of any proposed treatments. To image the arterial system, the aim of 3D modeling is to precisely assess and quantify the arterial morphology. The use of augmented reality before an endovascular procedure allows pre-treatment simulation, assisting in pre-operative planning as well as surgical training. In the special field of liver surgery, several 3D modeling software products are available for computer simulations and training purposes and augmented reality.

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