scholarly journals Recent advances in the manipulation of murine gene expression and its utility for the study of human neurological disease

2010 ◽  
Vol 1802 (10) ◽  
pp. 796-807 ◽  
Author(s):  
Chiara Cazzin ◽  
Christopher J.A. Ring
Keyword(s):  
Gene Expression ◽  
Neurological Disease ◽  
Recent Advances

scholarly journals Short RNAs in environmental adaptation

2006 ◽  
Vol 273 (1594) ◽  
pp. 1579-1585 ◽  
Author(s):  
Tamas Dalmay
Keyword(s):  
Gene Expression ◽  
Protein Complex ◽  
Small Rnas ◽  
Normal Development ◽  
Environmental Adaptation ◽  
Target Mrnas ◽  
Short Rnas ◽  
Recent Advances ◽  
Perfect Complementarity ◽  
Important Regulator

Non-coding small RNAs (19–24 nucleotide long) have recently been recognized as the important regulator of gene expression in both plants and animals. Several classes of endogenous short RNAs have partial or near perfect complementarity to mRNAs and a protein complex is guided by short RNAs to target mRNAs. The targeted mRNA is either cleaved or its translation is suppressed. Initially, short RNAs were believed to primarily regulate the normal development of plants and animals, but recent advances implicate short RNAs in environmental adaptation.

scholarly journals Recent Advances on the TPM4 Gene Expression in Humans

2016 ◽  
Vol 7 (12) ◽  
Author(s):  
Dipak K Dube ◽  
Syamalima Dube ◽  
Lynn Abbott ◽  
Bernard J Poiesz
Keyword(s):  
Gene Expression ◽  
Recent Advances

Recent development of novel HDAC6 isoform-selective inhibitors.

2020 ◽  
Vol 27 ◽  
Author(s):  
Yunpeng Zhao ◽  
Tao Liang ◽  
Xuben Hou ◽  
Hao Fang
Keyword(s):  
Gene Expression ◽  
Protein Structure ◽  
Histone Deacetylase ◽  
Chromatin Remodeling ◽  
Histone Deacetylation ◽  
Selective Inhibitors ◽  
Abnormal Expression ◽  
Physiological Processes ◽  
Recent Advances

: As an important posttranscription modification, histone deacetylation plays significant roles in chromatin remodeling and gene expression. The aberrant modification of histone deacetylation leads to various diseases. As a critical member of histone deacetylase (HDAC), HDAC6 serves as a key modulator in many physiological processes. Abnormal expression of HDAC6 gives rise to cancer, neurodegeneration and other diseases. Here, we reviewed recent advances in physiological, protein structure and development of HDAC6 selective inhibitors.

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