Exploring the structural basis of the selective inhibition of monoamine oxidase A by dicarbonitrile aminoheterocycles: Role of Asn181 and Ile335 validated by spectroscopic and computational studies

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Chlorine substitution on a 3,5-diphenyl-pyrazoline derivative enabled potent and selective inhibition of hMAO-A; calculations suggest an “aromatic sandwich” orientation is responsible.


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