High-dosage granulocyte colony stimulating factor treatment alters monocyte trafficking to the brain after experimental stroke

2017 ◽  
Vol 60 ◽  
pp. 15-26 ◽  
Author(s):  
Gesa Weise ◽  
Claudia Pösel ◽  
Karoline Möller ◽  
Alexander Kranz ◽  
Nadine Didwischus ◽  
...  
Keyword(s):  
Experimental Stroke ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
The Brain ◽  
Stimulating Factor ◽  
Monocyte Trafficking

Granulocyte colony-stimulating factor potential use in the treatment of children with cerebral palsy

2017 ◽  
Vol 7 (1) ◽  
pp. 0-0
Author(s):  
G. Paszko-Patej ◽  
D. Sienkiewicz ◽  
B. Okurowska-Zawada ◽  
W. Kułak
Keyword(s):  
Cerebral Palsy ◽  
Tissue Repair ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Neuroprotective Actions ◽  
Apoptosis And Inflammation ◽  
Brain And Spinal Cord ◽  
The Brain ◽  
Stimulating Factor ◽  
Potential Use

Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the blood. Recent studies demonstrated the presence of CSF-receptor (G-CSFR) system in the brain and spinal cord, and their roles in neuroprotection and neural tissue repair, as well as improvement in functional recovery. G-CSF exerts neuroprotective actions through the inhibition of apoptosis and inflammation, and the stimulation of neurogenesis. This review highlights recent studies on the potential use of G-CSF in cerebral palsy.

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