Granulocyte colony-stimulating factor potential use in the treatment of children with cerebral palsy

2017 ◽  
Vol 7 (1) ◽  
pp. 0-0
Author(s):  
G. Paszko-Patej ◽  
D. Sienkiewicz ◽  
B. Okurowska-Zawada ◽  
W. Kułak
Keyword(s):  
Cerebral Palsy ◽  
Tissue Repair ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Neuroprotective Actions ◽  
Apoptosis And Inflammation ◽  
Brain And Spinal Cord ◽  
The Brain ◽  
Stimulating Factor ◽  
Potential Use

Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the blood. Recent studies demonstrated the presence of CSF-receptor (G-CSFR) system in the brain and spinal cord, and their roles in neuroprotection and neural tissue repair, as well as improvement in functional recovery. G-CSF exerts neuroprotective actions through the inhibition of apoptosis and inflammation, and the stimulation of neurogenesis. This review highlights recent studies on the potential use of G-CSF in cerebral palsy.

Effects of granulocyte colony-stimulating factor treatment in children and patients with cerebral palsy: a preliminary report

2017 ◽  
Vol 7 (1) ◽  
pp. 78-82
Author(s):  
G. Paszko-Patej ◽  
W. Kułak ◽  
B. Okurowska-Zawada ◽  
D. Sienkiewicz ◽  
J. Wojtkowski ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Motor Function ◽  
Preliminary Report ◽  
Speech Development ◽  
System Level ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Stimulating Factor

neuroinflammation and apoptosis in brains affected by cerebral palsy could be therapeutic targets. Granulocyte colony-stimulating factor (G-CSF) exerts anti-inflammatory and antiapoptosis effects and stimulates the proliferation of neural stem and progenitor cells in the brain. Purpose: To assess the efficacy and safety of G-CSF treatment in children and adolescents with CP. Materials and methods: Six patients with spastic tetraplegia CP aged 3-15 years were enrolled in this study. Five patients had GMFCS (Gross Motor Function Classification System) level at V, three children had epilepsy, and three had severe mental retardation. We used the gross motor function measure-66 (GMFM-66) to assess motor function.GCSF (5μg/kg/body/day) was administered subcutaneously for five consecutive days during the four months. The parents also evaluated the physical and mental development of their children. Results: We observed improvement in motor function in patients with CP on the GMFM-66 scale. Parents reported improvement in behavior, speech development, and a decrease in spasticity in children with CP. G-CSF therapy was well-tolerated. No side effects were observed during the study. Conclusions: Our preliminary report suggests that G-CSF treatment improves motor and mental function in patients with CP. Further studies are needed to confirm these observations

scholarly journals Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Craig R. Wright ◽  
Alister C. Ward ◽  
Aaron P. Russell
Keyword(s):  
Skeletal Muscle ◽  
Tissue Repair ◽  
Therapeutic Agent ◽  
Strenuous Exercise ◽  
Muscle Repair ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Disease States ◽  
Tissue Repair And Regeneration ◽  
Stimulating Factor

Granulocyte colony-stimulating factor (G-CSF) was originally discovered in the context of hematopoiesis. However, the identification of the G-CSF receptor (G-CSFR) being expressed outside the hematopoietic system has revealed wider roles for G-CSF, particularly in tissue repair and regeneration. Skeletal muscle damage, including that following strenuous exercise, induces an elevation in plasma G-CSF, implicating it as a potential mediator of skeletal muscle repair. This has been supported by preclinical studies and clinical trials investigating G-CSF as a potential therapeutic agent in relevant disease states. This review focuses on the growing literature associated with G-CSF and G-CSFR in skeletal muscle under healthy and disease conditions and highlights the current controversies.

Detrimental role of granulocyte-colony stimulating factor in neuromyelitis optica: clinical case and histological evidence

2012 ◽  
Vol 18 (12) ◽  
pp. 1801-1803 ◽  
Author(s):  
Anu Jacob ◽  
Samira Saadoun ◽  
Joanna Kitley ◽  
Maria Leite ◽  
Jacqueline Palace ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Clinical Case ◽  
First Episode ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Histological Evidence ◽  
Normal White Matter ◽  
Brain And Spinal Cord ◽  
Stimulating Factor

In a recent study, administration of granulocyte colony stimulating factor (G-CSF) increased neuromyelitis optica (NMO) lesions in mice. Here we report a patient whose first episode of NMO may have been exacerbated by inadvertent administration of G-CSF. Histological examination of brain and spinal cord samples from three other NMO patients revealed markedly increased expression of G-CSF in neurons located in and around the lesions, with little or no expression in multiple sclerosis lesions or normal white matter. Taken together, these cases support a detrimental role for G-CSF in NMO pathogenesis.

Sign in / Sign up

Export Citation Format

Share Document