scholarly journals Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome

2019 ◽  
Vol 76 ◽  
pp. 82-96 ◽  
Author(s):  
Chinh Bkrong Nguyen ◽  
Surendra Kumar ◽  
Manuela Zucknick ◽  
Vessela N. Kristensen ◽  
Johannes Gjerstad ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Gene Networks ◽  
Clinical Symptoms ◽  
Chronic Fatigue ◽  
Plasma Norepinephrine ◽  
Immune Gene ◽  
Fatigue Syndrome

scholarly journals Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping

2021 ◽  
Vol 10 (18) ◽  
pp. 4171
Author(s):  
Jesús Castro-Marrero ◽  
Mario Zacares ◽  
Eloy Almenar-Pérez ◽  
José Alegre-Martín ◽  
Elisa Oltra
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Clinical Symptoms ◽  
Hierarchical Cluster ◽  
Chronic Fatigue ◽  
Blood Parameters ◽  
Myalgic Encephalomyelitis ◽  
Complement Factor ◽  
Fatigue Syndrome ◽  
Pain Symptoms ◽  
Rule Out

Background: Routine blood analytics are systematically used in the clinic to diagnose disease or confirm individuals’ healthy status. For myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disease relying exclusively on clinical symptoms for its diagnosis, blood analytics only serve to rule out underlying conditions leading to exerting fatigue. However, studies evaluating complete and large blood datasets by combinatorial approaches to evidence ME/CFS condition or detect/identify case subgroups are still scarce. Methods: This study used unbiased hierarchical cluster analysis of a large cohort of 250 carefully phenotyped female ME/CFS cases toward exploring this possibility. Results: The results show three symptom-based clusters, classified as severe, moderate, and mild, presenting significant differences (p < 0.05) in five blood parameters. Unexpectedly the study also revealed high levels of circulating complement factor C1q in 107/250 (43%) of the participants, placing C1q as a key molecule to identify an ME/CFS subtype/subgroup with more apparent pain symptoms. Conclusions: The results obtained have important implications for the research of ME/CFS etiology and, most likely, for the implementation of future diagnosis methods and treatments of ME/CFS in the clinic.

scholarly journals Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Efficacy of Repeat Immunoadsorption

2020 ◽  
Vol 9 (8) ◽  
pp. 2443 ◽  
Author(s):  
Markus Tölle ◽  
Helma Freitag ◽  
Michaela Antelmann ◽  
Jelka Hartwig ◽  
Mirjam Schuchardt ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Clinical Symptoms ◽  
Pilot Trial ◽  
Treatment Protocol ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Proof Of Concept ◽  
Rapid Improvement ◽  
Fatigue Syndrome

(1) Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex neuroimmunological disease. There is evidence for an autoimmune mechanism for ME/CFS with an infection-triggered onset and dysfunction of ß2-adrenoreceptor antibodies (ß2AR-AB). In a first proof-of-concept study, we could show that IA was effective to reduce ß2AR-AB and led to improvement of various symptoms. (2) Five of the ME/CFS patients who had clinical improvement following treatment with a five-day IA were retreated in the current study about two years later with a modified IA protocol. The severity of symptoms was assessed by disease specific scores during a follow-up period of 12 months. The antibodies were determined by ELISA. (3) The modified IA treatment protocol resulted in a remarkable similar clinical response. The treatment was well tolerated and 80–90% decline of total IgG and ß2AR-AB was achieved. Four patients showed a rapid improvement in several clinical symptoms during IA therapy, lasting for six to 12 months. One patient had no improvement. (4) We could provide further evidence that IA has clinical efficacy in patients with ME/CFS. Data from our pilot trial warrant further controlled studies in ME/CFS.

scholarly journals Are Traditional Remedies Useful in Management of Fibromyalgia and Chronic Fatigue Syndrome? A Review Study

2017 ◽  
Vol 22 (4) ◽  
pp. 1011-1016 ◽  
Author(s):  
Fatemeh Mahjoub ◽  
Roshanak Salari ◽  
Mohammad Reza Noras ◽  
Mahdi Yousefi
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Clinical Symptoms ◽  
Conventional Medicine ◽  
Chronic Fatigue ◽  
Fatigue Syndrome ◽  
Traditional Remedies ◽  
Persian Medicine ◽  
Persistent Fatigue ◽  
Traditional Persian Medicine ◽  
In The Beginning

Fibromyalgia and chronic fatigue syndrome are disorders that often occur simultaneously and are characterized by widespread pain and persistent fatigue. The patients are associated with disability and impairment social and physical functions. There are many remedies in traditional Persian medicine suggested for management of the disease complaints. The aim of this study was to investigate the clinical presentations and pathophysiology of disorders with the basic and principal textbook of traditional Persian medicine written by Avicenna ( Canon of Medicine). According to Persian medicine, the term E’aya can be matched by mentioned disorders. Avicenna believed that strenuous activities play an important role in the beginning of some types of fatigue. He classified fatigue into 4 groups, and in each type the clinical symptoms varied. The multifaceted entity of fibromyalgia and chronic fatigue syndrome in Persian medicine and conventional medicine suggests multidisciplinary therapies in management of these disabling disorders.

scholarly journals Potential of Activin B as a Clinical Biomarker in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1189
Author(s):  
Sabine Gravelsina ◽  
Zaiga Nora-Krukle ◽  
Anda Vilmane ◽  
Simons Svirskis ◽  
Katrine Vecvagare ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Complex Disease ◽  
Clinical Symptoms ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Healthy Controls ◽  
Fatigue Syndrome ◽  
Age Related ◽  
Diagnostic Potential ◽  
Clinical Biomarker

Reliable serum biomarkers are of immense need for diagnostic purposes of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)—a disabling and complex disease for which diagnosis is mainly based on clinical symptoms. The aim of this study was to evaluate a possible diagnostic potential of activin B by directly comparing 134 cases of ME/CFS with 54 healthy controls. Analyses of human activin B level in plasma samples were performed using a validated human activin B ELISA assay. The results of the study show that activin B levels did not differ statistically significantly between ME/CFS patients and healthy controls (p = 0.6511). No gender or age-related differences in activin B levels were observed in the ME/CFS group and healthy controls. The level of activin B tended to decrease with increasing visual analogue scale score (r = −0.2004; p = 0.5085) nevertheless the results obtained so far does not support the clinical utility of activin B as a biomarker for ME/CFS.

scholarly journals Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology

2012 ◽  
Vol 25 (9) ◽  
pp. 1073-1087 ◽  
Author(s):  
Dikoma C. Shungu ◽  
Nora Weiduschat ◽  
James W. Murrough ◽  
Xiangling Mao ◽  
Sarah Pillemer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Fatigue Syndrome ◽  
Clinical Symptoms ◽  
Chronic Fatigue ◽  
Fatigue Syndrome

scholarly journals Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2021 ◽  
Vol 10 (14) ◽  
pp. 3105
Author(s):  
Ingrid H. Baklund ◽  
Toril Dammen ◽  
Torbjørn Åge Moum ◽  
Wenche Kristiansen ◽  
Daysi Sosa Duarte ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Clinical Symptoms ◽  
Chronic Fatigue ◽  
Mean Difference ◽  
Myalgic Encephalomyelitis ◽  
Psychiatric Evaluation ◽  
Healthy Controls ◽  
Blood Tests ◽  
Fatigue Syndrome ◽  
And Gender

There is a lack of research regarding blood tests within individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and between patients and healthy controls. We aimed to compare results of routine tests between patients and healthy controls. Data from 149 patients diagnosed with ME/CFS based on clinical and psychiatric evaluation as well as on the DePaul Symptom Questionnaire, and data from 264 healthy controls recruited from blood donors were compared. One-way ANCOVA was conducted to examine differences between ME/CFS patients and healthy controls, adjusting for age and gender. Patients had higher sedimentation rate (mean difference: 1.38, 95% CI: 0.045 to 2.714), leukocytes (mean difference: 0.59, 95% CI: 0.248 to 0.932), lymphocytes (mean difference: 0.27, 95% CI: 0.145 to 0.395), neutrophils (mean difference: 0.34, 95% CI: 0.0 89 to 0.591), monocytes (mean difference: 0.34, 95% CI: 0.309 to 0.371), ferritin (mean difference: 28.13 95% CI: −1.41 to 57.672), vitamin B12 (mean difference: 83.43, 95% CI: 62.89 to 124.211), calcium (mean difference: 0.02, 95% CI: −0.02 to 0.06), alanine transaminase (ALAT) (mean difference: 3.30, 95% CI: −1.37 to -7.971), low-density lipoproteins (mean difference: 0.45, 95% CI: 0.104 to 0.796), and total proteins (mean difference: 1.53, 95% CI: −0.945 to 4.005) than control subjects. The patients had lower potassium levels (mean difference: 0.11, 95% CI: 0.056 to 0.164), creatinine (mean difference: 2.60; 95% CI: 0.126 to 5.074) and creatine kinase (CK) (mean difference: 37.57 95% CI: −0.282 to 75.422) compared to the healthy controls. Lower CK and creatinine levels may suggest muscle damage and metabolic abnormalities in ME/CFS patients.

scholarly journals Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe—the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review

BMJ Open ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. e020817 ◽  
Author(s):  
Fernando Estévez-López ◽  
Jesus Castro-Marrero ◽  
Xia Wang ◽  
Inger Johanne Bakken ◽  
Andrejs Ivanovs ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Clinical Symptoms ◽  
Healthcare Providers ◽  
Reporting Quality ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
European Network ◽  
Fatigue Syndrome

IntroductionMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic disease involving central nervous system and immune system disorders, as well as cardiovascular abnormalities. ME/CFS is characterised by severe chronic fatigue lasting for at least 6 months, including clinical symptoms such as tender cervical or axillary lymph nodes, muscle pain, joint pain without swelling or redness, post-exertional malaise for more than 24 hours and unrefreshing sleep. Studies on the epidemiology of ME/CFS in Europe only include single countries and, therefore, the prevalence and incidence of ME/CFS in Europe (as a whole) is unknown. One of the purposes of the European Network on ME/CFS (EUROMENE; European Union-funded COST Action; Reference number: 15111) is to address this gap in knowledge. We will systematically review the literature reporting figures from European countries to provide a robust summary and identify new challenges.Methods and analysisWe will systematically search the literature databases Scopus, PubMed and Web of Science for studies published in the last 10 years (ie, after 2007). No language restriction will be applied. Two independent reviewers will search, screen and select studies as well as extract data about their main characteristics and evaluate their methodological and reporting quality. When disagreements emerge, the reviewers will discuss to reach a consensus. We plan to produce a narrative summary of our findings as we anticipate that studies are scarce and heterogeneous. The possibility of performing meta-analyses will be discussed in a EUROMENE meeting.Ethics and disseminationEthical approval is not required as only publicly available data will be included. Findings will be described in EUROMENE reports, published in peer-reviewed journal(s) and presented at conferences. The findings will be also communicated to policy-makers, healthcare providers, people with ME/CFS and other sections of society through regular channels including the mass-media.PROSPERO registration numberCRD42017078688

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