scholarly journals The role of the microbiota in acute stress-induced myeloid immune cell trafficking

2020 ◽  
Vol 84 ◽  
pp. 209-217 ◽  
Author(s):  
Marcel van de Wouw ◽  
Joshua M. Lyte ◽  
Marcus Boehme ◽  
Marzia Sichetti ◽  
Gerard Moloney ◽  
...  
Keyword(s):  
Immune Cell ◽  
Acute Stress ◽  
Cell Trafficking ◽  
Immune Cell Trafficking

scholarly journals Immunotherapy in CNS cancers: the role of immune cell trafficking

2018 ◽  
Vol 21 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Nivedita M Ratnam ◽  
Mark R Gilbert ◽  
Amber J Giles
Keyword(s):  
Immune Cell ◽  
Cell Trafficking ◽  
Immune Cell Trafficking

Role of the lymphatic vasculature in cardiovascular medicine

Heart ◽  
2019 ◽  
Vol 105 (23) ◽  
pp. 1777-1784 ◽  
Author(s):  
Niklas Telinius ◽  
Vibeke Elisabeth Hjortdal
Keyword(s):  
Immune Cell ◽  
Treatment Options ◽  
Molecular Medicine ◽  
Future Research ◽  
Cell Trafficking ◽  
Cardiovascular Medicine ◽  
Immune Cell Trafficking ◽  
Lymphatic Vasculature ◽  
Factor C

The lymphatic vasculature has traditionally been considered important for removal of excessive fluid from the interstitial space, absorption of fat from the intestine and the immune system. Advances in molecular medicine and imaging have provided us with new tools to study the lymphatics. This has revealed that the vessels are actively involved in regulation of immune cell trafficking and inflammation. We now know much about how new lymphatic vessels are created (lymphangiogenesis) and that this is important in, for example, wound healing and tissue repair. The best characterised pathway for lymphangiogenesis is the vascular endothelial growth factor C (VEGF-C)/VEGFR3 pathway. Over recent years, there has been an increasing interest in the role of the lymphatics in cardiovascular medicine. Preclinical studies have shown that lymphangiogenesis and immune cell trafficking play a role in cardiovascular conditions such as atherosclerosis, recovery after myocardial infarction and rejection of cardiac allografts. Targeting the VEGF-C/VEGFR3 pathway can be beneficial in these conditions. The clinical spectrum of lymphatic abnormalities and lymphoedema is wide and overlaps with congenital heart disease. Important long-term complications to the Fontan circulation involves the lymphatics. New and improved imaging modalities has improved our understanding and management of these patients. Lymphatic leaks and flow abnormalities can be successfully treated, minimally invasively, with percutaneous embolisation. Future research will prove if the preclinical findings that point to a role of the lymphatics in several cardiovascular conditions will result in new treatment options.

The Role of Lysophospholipids in Immune Cell Trafficking and Inflammation

2016 ◽  
pp. 459-471
Author(s):  
Masayuki Miyasaka ◽  
Akira Takeda ◽  
Erina Hata ◽  
Naoko Sasaki ◽  
Eiji Umemoto ◽  
...  
Keyword(s):  
Immune Cell ◽  
Cell Trafficking ◽  
Immune Cell Trafficking

scholarly journals Targeting Immune Cell Trafficking – Insights From Research Models and Implications for Future IBD Therapy

2021 ◽  
Vol 12 ◽  
Author(s):  
Maximilian Wiendl ◽  
Emily Becker ◽  
Tanja M. Müller ◽  
Caroline J. Voskens ◽  
Markus F. Neurath ◽  
...  
Keyword(s):  
Immune Cell ◽  
Therapeutic Interventions ◽  
Cell Trafficking ◽  
Future Directions ◽  
Immune Cell Trafficking ◽  
Multifactorial Diseases ◽  
Medical Need ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC) are multifactorial diseases with still unknown aetiology and an increasing prevalence and incidence worldwide. Despite plentiful therapeutic options for IBDs, the lack or loss of response in certain patients demands the development of further treatments to tackle this unmet medical need. In recent years, the success of the anti-α4β7 antibody vedolizumab highlighted the potential of targeting the homing of immune cells, which is now an important pillar of IBD therapy. Due to its complexity, leukocyte trafficking and the involved molecules offer a largely untapped resource for a plethora of potential therapeutic interventions. In this review, we aim to summarise current and future directions of specifically interfering with immune cell trafficking. We will comment on concepts of homing, retention and recirculation and particularly focus on the role of tissue-derived chemokines. Moreover, we will give an overview of the mode of action of drugs currently in use or still in the pipeline, highlighting their mechanisms and potential to reduce disease burden.

HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes

2012 ◽  
Vol 12 (11) ◽  
pp. 762-773 ◽  
Author(s):  
Jean-Philippe Girard ◽  
Christine Moussion ◽  
Reinhold Förster
Keyword(s):  
Lymph Nodes ◽  
Immune Cell ◽  
Cell Trafficking ◽  
Immune Cell Trafficking

Immune cell trafficking in uterus and early life is dominated by the mucosal addressin MAdCAM-1 in humans

2001 ◽  
Vol 121 (4) ◽  
pp. 853-864 ◽  
Author(s):  
Marko Salmi ◽  
Kalle Alanen ◽  
Seija Grenman ◽  
Michael Briskin ◽  
Eugene C. Butcher ◽  
...  
Keyword(s):  
Early Life ◽  
Immune Cell ◽  
Cell Trafficking ◽  
Immune Cell Trafficking

scholarly journals The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer

2019 ◽  
Vol 10 ◽  
Author(s):  
Andrew O. Yam ◽  
Tatyana Chtanova
Keyword(s):  
Skin Cancer ◽  
Immune Cell ◽  
Cell Trafficking ◽  
Immune Cell Trafficking

scholarly journals The molecular cues regulating immune cell trafficking

2017 ◽  
Vol 93 (4) ◽  
pp. 183-195 ◽  
Author(s):  
Akira TAKEDA ◽  
Naoko SASAKI ◽  
Masayuki MIYASAKA
Keyword(s):  
Immune Cell ◽  
Cell Trafficking ◽  
Immune Cell Trafficking

scholarly journals Regulation of immune cell trafficking by febrile temperatures

2019 ◽  
Vol 36 (sup1) ◽  
pp. 17-21
Author(s):  
ChangDong Lin ◽  
JianFeng Chen
Keyword(s):  
Immune Cell ◽  
Cell Trafficking ◽  
Immune Cell Trafficking
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