Role of the lymphatic vasculature in cardiovascular medicine

Heart ◽  
2019 ◽  
Vol 105 (23) ◽  
pp. 1777-1784 ◽  
Author(s):  
Niklas Telinius ◽  
Vibeke Elisabeth Hjortdal
Keyword(s):  
Immune Cell ◽  
Treatment Options ◽  
Molecular Medicine ◽  
Future Research ◽  
Cell Trafficking ◽  
Cardiovascular Medicine ◽  
Immune Cell Trafficking ◽  
Lymphatic Vasculature ◽  
Factor C

The lymphatic vasculature has traditionally been considered important for removal of excessive fluid from the interstitial space, absorption of fat from the intestine and the immune system. Advances in molecular medicine and imaging have provided us with new tools to study the lymphatics. This has revealed that the vessels are actively involved in regulation of immune cell trafficking and inflammation. We now know much about how new lymphatic vessels are created (lymphangiogenesis) and that this is important in, for example, wound healing and tissue repair. The best characterised pathway for lymphangiogenesis is the vascular endothelial growth factor C (VEGF-C)/VEGFR3 pathway. Over recent years, there has been an increasing interest in the role of the lymphatics in cardiovascular medicine. Preclinical studies have shown that lymphangiogenesis and immune cell trafficking play a role in cardiovascular conditions such as atherosclerosis, recovery after myocardial infarction and rejection of cardiac allografts. Targeting the VEGF-C/VEGFR3 pathway can be beneficial in these conditions. The clinical spectrum of lymphatic abnormalities and lymphoedema is wide and overlaps with congenital heart disease. Important long-term complications to the Fontan circulation involves the lymphatics. New and improved imaging modalities has improved our understanding and management of these patients. Lymphatic leaks and flow abnormalities can be successfully treated, minimally invasively, with percutaneous embolisation. Future research will prove if the preclinical findings that point to a role of the lymphatics in several cardiovascular conditions will result in new treatment options.

scholarly journals Immunotherapy in CNS cancers: the role of immune cell trafficking

2018 ◽  
Vol 21 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Nivedita M Ratnam ◽  
Mark R Gilbert ◽  
Amber J Giles
Keyword(s):  
Immune Cell ◽  
Cell Trafficking ◽  
Immune Cell Trafficking

The Role of Lysophospholipids in Immune Cell Trafficking and Inflammation

2016 ◽  
pp. 459-471
Author(s):  
Masayuki Miyasaka ◽  
Akira Takeda ◽  
Erina Hata ◽  
Naoko Sasaki ◽  
Eiji Umemoto ◽  
...  
Keyword(s):  
Immune Cell ◽  
Cell Trafficking ◽  
Immune Cell Trafficking

scholarly journals The role of the microbiota in acute stress-induced myeloid immune cell trafficking

2020 ◽  
Vol 84 ◽  
pp. 209-217 ◽  
Author(s):  
Marcel van de Wouw ◽  
Joshua M. Lyte ◽  
Marcus Boehme ◽  
Marzia Sichetti ◽  
Gerard Moloney ◽  
...  
Keyword(s):  
Immune Cell ◽  
Acute Stress ◽  
Cell Trafficking ◽  
Immune Cell Trafficking

scholarly journals Targeting Immune Cell Trafficking – Insights From Research Models and Implications for Future IBD Therapy

2021 ◽  
Vol 12 ◽  
Author(s):  
Maximilian Wiendl ◽  
Emily Becker ◽  
Tanja M. Müller ◽  
Caroline J. Voskens ◽  
Markus F. Neurath ◽  
...  
Keyword(s):  
Immune Cell ◽  
Therapeutic Interventions ◽  
Cell Trafficking ◽  
Future Directions ◽  
Immune Cell Trafficking ◽  
Multifactorial Diseases ◽  
Medical Need ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC) are multifactorial diseases with still unknown aetiology and an increasing prevalence and incidence worldwide. Despite plentiful therapeutic options for IBDs, the lack or loss of response in certain patients demands the development of further treatments to tackle this unmet medical need. In recent years, the success of the anti-α4β7 antibody vedolizumab highlighted the potential of targeting the homing of immune cells, which is now an important pillar of IBD therapy. Due to its complexity, leukocyte trafficking and the involved molecules offer a largely untapped resource for a plethora of potential therapeutic interventions. In this review, we aim to summarise current and future directions of specifically interfering with immune cell trafficking. We will comment on concepts of homing, retention and recirculation and particularly focus on the role of tissue-derived chemokines. Moreover, we will give an overview of the mode of action of drugs currently in use or still in the pipeline, highlighting their mechanisms and potential to reduce disease burden.

scholarly journals Decision Making from the Experience of Orthognathic Surgery Patients: A Grounded Theory Approach

2021 ◽  
pp. 238008442110144
Author(s):  
N.R. Paul ◽  
S.R. Baker ◽  
B.J. Gibson
Keyword(s):  
Decision Making ◽  
Grounded Theory ◽  
Treatment Options ◽  
Study Data ◽  
Primary Objective ◽  
Major Surgery ◽  
Future Research ◽  
Decision Making Process ◽  
Theory Approach

Introduction: Patients’ decisions to undergo major surgery such as orthognathic treatment are not just about how the decision is made but what influences the decision. Objectives: The primary objective of the study was to identify the key processes involved in patients’ experience of decision making for orthognathic treatment. Methods: This study reports some of the findings of a larger grounded theory study. Data were collected through face-to-face interviews of patients who were seen for orthognathic treatment at a teaching hospital in the United Kingdom. Twenty-two participants were recruited (age range 18–66 y), of whom 12 (male = 2, female = 10) were 6 to 8 wk postsurgery, 6 (male = 2, female = 4) were in the decision-making stage, and 4 (male = 0, female = 4) were 1 to 2 y postsurgery. Additional data were also collected from online blogs and forums on jaw surgery. The data analysis stages of grounded theory methodology were undertaken, including open and selective coding. Results: The study identified the central role of dental care professionals (DCPs) in several underlying processes associated with decision making, including legitimating, mediating, scheduling, projecting, and supporting patients’ decisions. Six categories were related to key aspects of decision making. These were awareness about their underlying dentofacial problems and treatment options available, the information available about the treatment, the temporality of when surgery would be undertaken, the motivations and expectation of patients, social support, and fear of the surgery, hospitalization, and potentially disliking their new face. Conclusion: The decision-making process for orthognathic treatment is complex, multifactorial, and heavily influenced by the role of DCPs in patient care. Understanding the magnitude of this role will enable DCPs to more clearly participate in improving patients’ decision-making process. The findings of this study can inform future quantitative studies. Knowledge Transfer Statement: The results of this study can be used both for informing clinical practice around enabling decision making for orthognathic treatment and also for designing future research. The findings can better inform clinicians about the importance of their role in the patients’ decision-making process for orthognathic treatment and the means to improve the patient experience. It is suggested that further research could be conducted to measure some of the key constructs identified within our grounded theory and assess how these change during the treatment process.

HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes

2012 ◽  
Vol 12 (11) ◽  
pp. 762-773 ◽  
Author(s):  
Jean-Philippe Girard ◽  
Christine Moussion ◽  
Reinhold Förster
Keyword(s):  
Lymph Nodes ◽  
Immune Cell ◽  
Cell Trafficking ◽  
Immune Cell Trafficking

Immune cell trafficking in uterus and early life is dominated by the mucosal addressin MAdCAM-1 in humans

2001 ◽  
Vol 121 (4) ◽  
pp. 853-864 ◽  
Author(s):  
Marko Salmi ◽  
Kalle Alanen ◽  
Seija Grenman ◽  
Michael Briskin ◽  
Eugene C. Butcher ◽  
...  
Keyword(s):  
Early Life ◽  
Immune Cell ◽  
Cell Trafficking ◽  
Immune Cell Trafficking

Endometriosis

2019 ◽  
Author(s):  
Valerie A Flores ◽  
Hugh S Taylor
Keyword(s):  
Pelvic Pain ◽  
Treatment Options ◽  
Reproductive Age ◽  
Fertility Treatment ◽  
Future Research ◽  
Retrograde Menstruation ◽  
Reproductive Age Women ◽  
Aberrant Gene Expression ◽  
Aberrant Gene

Endometriosis is a chronic, gynecologic disease affecting 6 to 10% of reproductive age women. Pelvic pain, dyspareunia, and infertility are the most common symptoms of endometriosis that can have a significant impact on patients’ lives. Although the etiology remains largely unknown, the role of estrogens in the development and growth of endometriosis is well characterized. Medical and surgical therapies are the two cornerstones of endometriosis management. Following diagnosis of endometriosis, treatment options will be dependent on patient preference (ie, seeking pain relief versus fertility treatment). Future research aimed at targeting altered molecular pathways in patients with endometriosis will hopefully help mitigate the burden of this debilitating disease. This review contains 5 figures, 7 tables, and 75 references. Key Words: aberrant gene expression, altered immunity, endometriosis, infertility, medical and surgical therapy, pelvic pain, retrograde menstruation, stem cells

Sign in / Sign up

Export Citation Format

Share Document