Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure

2008 ◽  
Vol 190 (1) ◽  
pp. 85-96 ◽  
Author(s):  
Stan B. Floresco ◽  
Annie E. Block ◽  
Maric T.L. Tse
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Reversal Learning ◽  
Set Shifting

scholarly journals The claustrum-medial prefrontal cortex network controls attentional set-shifting

2020 ◽  
Author(s):  
Leon Fodoulian ◽  
Olivier Gschwend ◽  
Chieko Huber ◽  
Sophie Mutel ◽  
Rodrigo F. Salazar ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Cognitive Deficits ◽  
Pyramidal Cells ◽  
Excitatory Input ◽  
Set Shifting ◽  
Attentional Set ◽  
Attentional Set Shifting ◽  
Reciprocal Connections

SUMMARYIn various mental disorders, dysfunction of the prefrontal cortex contributes to cognitive deficits. Here we studied how the claustrum (CLA), a nucleus sharing reciprocal connections with the cortex, may participate in these cognitive impairments. We show that specific ensembles of CLA and of medial prefrontal cortex (mPFC) neurons are activated during a task requiring cognitive control such as attentional set-shifting, i.e. the ability to shift attention towards newly relevant stimulus-reward associations while disengaging from irrelevant ones. CLA neurons exert a direct excitatory input on mPFC pyramidal cells, and chemogenetic inhibition of CLA neurons suppresses the formation of specific mPFC assemblies during attentional set-shifting. Furthermore, impairing the recruitment of specific CLA assemblies through opto/chemogenetic manipulations prevents attentional set-shifting. In conclusion, we propose that the CLA controls the reorganization of mPFC ensembles to enable attentional set-shifting, emphasizing a potential role of the CLA-mPFC network in attentional dysfunctions.

366 – Asenapine ameliorates set-shifting deficit in rats with medial prefrontal cortex lesion

2008 ◽  
Vol 98 ◽  
pp. 184
Author(s):  
V. Brown ◽  
H. Marston ◽  
D. Tait ◽  
L. Porrino ◽  
M. Shahid
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Set Shifting ◽  
Cortex Lesion

scholarly journals Multiple Dopamine Receptor Subtypes in the Medial Prefrontal Cortex of the Rat Regulate Set-Shifting

2005 ◽  
Vol 31 (2) ◽  
pp. 297-309 ◽  
Author(s):  
Stan B Floresco ◽  
Orsolya Magyar ◽  
Sarvin Ghods-Sharifi ◽  
Claudia Vexelman ◽  
Maric T L Tse
Keyword(s):  
Prefrontal Cortex ◽  
Dopamine Receptor ◽  
Medial Prefrontal Cortex ◽  
Receptor Subtypes ◽  
Set Shifting ◽  
Dopamine Receptor Subtypes
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