scholarly journals Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Amira Latif-Hernandez ◽  
Disha Shah ◽  
Tariq Ahmed ◽  
Adrian C. Lo ◽  
Zsuzsanna Callaerts-Vegh ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Plasticity ◽  
Medial Prefrontal Cortex ◽  
Reversal Learning ◽  
Quinolinic Acid ◽  
Cortical Connectivity ◽  
Learning Abilities ◽  
Hippocampal Synaptic Plasticity ◽  
Acid Injection

Inactivation of BRD7 results in impaired cognitive behavior and reduced synaptic plasticity of the medial prefrontal cortex

2015 ◽  
Vol 286 ◽  
pp. 1-10 ◽  
Author(s):  
Yang Xu ◽  
Wenyu Cao ◽  
Ming Zhou ◽  
Changqi Li ◽  
Yanwei Luo ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Plasticity ◽  
Medial Prefrontal Cortex ◽  
Cognitive Behavior

scholarly journals Impaired instrumental reversal learning is associated with increased medial prefrontal cortex activity in Sapap3 knockout mouse model of compulsive behavior

2018 ◽  
Vol 44 (8) ◽  
pp. 1494-1504 ◽  
Author(s):  
Elizabeth E. Manning ◽  
Alexandre Y. Dombrovski ◽  
Mary M. Torregrossa ◽  
Susanne E. Ahmari
Keyword(s):  
Prefrontal Cortex ◽  
Mouse Model ◽  
Medial Prefrontal Cortex ◽  
Reversal Learning ◽  
Knockout Mouse ◽  
Compulsive Behavior ◽  
Knockout Mouse Model

scholarly journals Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Haley A. Vecchiarelli ◽  
Chaitanya P. Gandhi ◽  
Matthew N. Hill
Keyword(s):  
Prefrontal Cortex ◽  
Psychological Stress ◽  
Medial Prefrontal Cortex ◽  
Quinolinic Acid ◽  
Time Course ◽  
Expression Patterns ◽  
Kynurenine Pathway ◽  
Male Rats ◽  
Published Data ◽  
Acute Psychological Stress

Tryptophan is an essential dietary amino acid that is necessary for protein synthesis, but also serves as the precursor for serotonin. However, in addition to these biological functions, tryptophan also serves as a precursor for the kynurenine pathway, which has neurotoxic (quinolinic acid) and neuroprotective (kynurenic acid) metabolites. Glucocorticoid hormones and inflammatory mediators, both of which are increased by stress, have been shown to bias tryptophan along the kynurenine pathway and away from serotonin synthesis; however, to date, there is no published data regarding the effects of stress on enzymes regulating the kynurenine pathway in a regional manner throughout the brain. Herein, we examined the effects of an acute psychological stress (120 min restraint) on gene expression patterns of enzymes along the kynurenine pathway over a protracted time-course (1–24 h post-stress termination) within the amygdala, hippocampus, hypothalamus, and medial prefrontal cortex. Time-dependent changes in differential enzymes along the kynurenine metabolism pathway, particularly those involved in the production of quinolinic acid, were found within the amygdala, hypothalamus, and medial prefrontal cortex, with no changes seen in the hippocampus. These regional differences acutely may provide mechanistic insight into processes that become dysregulated chronically in stress-associated disorders.

scholarly journals Medial Prefrontal Cortex Inversely Regulates Toluene-Induced Changes in Markers of Synaptic Plasticity of Mesolimbic Dopamine Neurons

2013 ◽  
Vol 33 (2) ◽  
pp. 804-813 ◽  
Author(s):  
J. T. Beckley ◽  
C. E. Evins ◽  
H. Fedarovich ◽  
M. J. Gilstrap ◽  
J. J. Woodward
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Plasticity ◽  
Medial Prefrontal Cortex ◽  
Dopamine Neurons ◽  
Mesolimbic Dopamine ◽  
Induced Changes

Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats

2016 ◽  
Vol 301 ◽  
pp. 43-54 ◽  
Author(s):  
Filipe C. Matheus ◽  
Daniel Rial ◽  
Joana I. Real ◽  
Cristina Lemos ◽  
Juliana Ben ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Plasticity ◽  
Medial Prefrontal Cortex ◽  
Short Term Memory ◽  
Memory Deficits ◽  
Short Term ◽  
Term Memory

Changes in synaptic plasticity in the rat hippocampo-medial prefrontal cortex pathway induced by repeated treatments with fluvoxamine

2002 ◽  
Vol 949 (1-2) ◽  
pp. 131-138 ◽  
Author(s):  
Satoshi Ohashi ◽  
Machiko Matsumoto ◽  
Hiroshi Otani ◽  
Kiyoshi Mori ◽  
Hiroko Togashi ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Plasticity ◽  
Medial Prefrontal Cortex

scholarly journals Learning-induced intrinsic and synaptic plasticity in the rodent medial prefrontal cortex

2020 ◽  
Vol 169 ◽  
pp. 107117
Author(s):  
James T. Porter ◽  
Marian T. Sepulveda-Orengo
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Plasticity ◽  
Medial Prefrontal Cortex
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