scholarly journals Rewarding effects of M4 but not M3 muscarinic cholinergic receptor antagonism in the rostromedial tegmental nucleus

2020 ◽  
Vol 379 ◽  
pp. 112340
Author(s):  
Nicole Buie ◽  
Dharm Sodha ◽  
Sarah B. Scheinman ◽  
Stephan Steidl
Keyword(s):  
Cholinergic Receptor ◽  
Muscarinic Cholinergic Receptor ◽  
Receptor Antagonism ◽  
Tegmental Nucleus ◽  
Rostromedial Tegmental Nucleus ◽  
Muscarinic Cholinergic

scholarly journals Overnight transdermal scopolamine patch administration has no clear effect on cognition and emotional processing in healthy volunteers

2018 ◽  
Vol 33 (2) ◽  
pp. 255-257 ◽  
Author(s):  
Bernard R Bukala ◽  
Michael Browning ◽  
Philip J Cowen ◽  
Catherine J Harmer ◽  
Susannah E Murphy
Keyword(s):  
Working Memory ◽  
Healthy Volunteers ◽  
Emotional Processing ◽  
Cholinergic Receptor ◽  
Double Blind ◽  
Muscarinic Cholinergic Receptor ◽  
Clear Effect ◽  
Antidepressant Effects ◽  
Muscarinic Cholinergic ◽  
First Time

There has been increasing interest in the antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine. Here we assess, for the first time, whether a transdermal scopolamine patch is sufficient to induce changes in cognition that are consistent with the reported cognitive and antidepressant effects of scopolamine. A scopolamine or placebo patch was administered to healthy volunteers ( n=33) for 17 h in a double-blind, between-subject procedure. There was no clear effect of scopolamine patch on emotional cognition, verbal or working memory, suggesting that the effective dose of scopolamine available through the patch is too low to represent a viable antidepressant mechanism.

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