Strain differences in muscarinic cholinergic receptor antagonism of fat intake and acquisition and expression of fat-conditioned flavor preferences in male BALB/c, C57BL/6 and SWR mice

2019 ◽  
Vol 187 ◽  
pp. 172792 ◽  
Author(s):  
Ben Iskhakov ◽  
Petra Dohnalova ◽  
Julia Iskhakova ◽  
Tatjana Mustac ◽  
Asnat Yuabov ◽  
...  
Keyword(s):  
Strain Differences ◽  
Cholinergic Receptor ◽  
Fat Intake ◽  
Muscarinic Cholinergic Receptor ◽  
Receptor Antagonism ◽  
Muscarinic Cholinergic ◽  
Conditioned Flavor

scholarly journals Overnight transdermal scopolamine patch administration has no clear effect on cognition and emotional processing in healthy volunteers

2018 ◽  
Vol 33 (2) ◽  
pp. 255-257 ◽  
Author(s):  
Bernard R Bukala ◽  
Michael Browning ◽  
Philip J Cowen ◽  
Catherine J Harmer ◽  
Susannah E Murphy
Keyword(s):  
Working Memory ◽  
Healthy Volunteers ◽  
Emotional Processing ◽  
Cholinergic Receptor ◽  
Double Blind ◽  
Muscarinic Cholinergic Receptor ◽  
Clear Effect ◽  
Antidepressant Effects ◽  
Muscarinic Cholinergic ◽  
First Time

There has been increasing interest in the antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine. Here we assess, for the first time, whether a transdermal scopolamine patch is sufficient to induce changes in cognition that are consistent with the reported cognitive and antidepressant effects of scopolamine. A scopolamine or placebo patch was administered to healthy volunteers ( n=33) for 17 h in a double-blind, between-subject procedure. There was no clear effect of scopolamine patch on emotional cognition, verbal or working memory, suggesting that the effective dose of scopolamine available through the patch is too low to represent a viable antidepressant mechanism.

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