Action of apoptotic endonuclease DNase γ on naked DNA and chromatin substrates

2006 ◽  
Vol 345 (2) ◽  
pp. 560-567 ◽  
Author(s):  
Ryushin Mizuta ◽  
Midori Mizuta ◽  
Shinsuke Araki ◽  
Daisuke Shiokawa ◽  
Sei-ichi Tanuma ◽  
...  
Keyword(s):  
Dnase Γ ◽  
Naked Dna

Non-Viral Vectors for Gene Delivery

2018 ◽  
Vol 9 (1) ◽  
pp. 4-11 ◽  
Author(s):  
Aparna Bansal ◽  
Himanshu
Keyword(s):  
Gene Therapy ◽  
Viral Vectors ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Expression System ◽  
Target Cells ◽  
Specific Expression ◽  
Naked Dna

Introduction: Gene therapy has emerged out as a promising therapeutic pave for the treatment of genetic and acquired diseases. Gene transfection into target cells using naked DNA is a simple and safe approach which has been further improved by combining vectors or gene carriers. Both viral and non-viral approaches have achieved a milestone to establish this technique, but non-viral approaches have attained a significant attention because of their favourable properties like less immunotoxicity and biosafety, easy to produce with versatile surface modifications, etc. Literature is rich in evidences which revealed that undoubtedly, non–viral vectors have acquired a unique place in gene therapy but still there are number of challenges which are to be overcome to increase their effectiveness and prove them ideal gene vectors. Conclusion: To date, tissue specific expression, long lasting gene expression system, enhanced gene transfection efficiency has been achieved with improvement in delivery methods using non-viral vectors. This review mainly summarizes the various physical and chemical methods for gene transfer in vitro and in vivo.

Accumulation of Human Apolipoprotein-E in Rat Plasma After in vivo Intramuscular Injection of Naked DNA

1994 ◽  
Vol 200 (1) ◽  
pp. 298-305 ◽  
Author(s):  
V.M. Fazio ◽  
S. Fazio ◽  
M. Rinaldi ◽  
M.V. Catani ◽  
S. Zotti ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Intramuscular Injection ◽  
Rat Plasma ◽  
Human Apolipoprotein ◽  
Naked Dna

In vivo monitoring of DNA vaccine gene expression using firefly luciferase as a naked DNA

Vaccine ◽  
2006 ◽  
Vol 24 (16) ◽  
pp. 3057-3062 ◽  
Author(s):  
Y JEON ◽  
Y CHOI ◽  
J KANG ◽  
J CHUNG ◽  
Y LEE ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Vaccine ◽  
Firefly Luciferase ◽  
In Vivo Monitoring ◽  
Naked Dna ◽  
Vaccine Gene

scholarly journals Optimization of regional intraarterial naked DNA-mediated transgene delivery to skeletal muscles in a large animal model

2005 ◽  
Vol 11 (2) ◽  
pp. 257-266 ◽  
Author(s):  
Gawiyou Danialou ◽  
Alain S. Comtois ◽  
Stefan Matecki ◽  
Josephine Nalbantoglu ◽  
George Karpati ◽  
...  
Keyword(s):  
Animal Model ◽  
Skeletal Muscles ◽  
Large Animal Model ◽  
Large Animal ◽  
Naked Dna ◽  
Transgene Delivery

DNase γ, DNase I and caspase-activated DNase cooperate to degrade dead cells

2016 ◽  
Vol 21 (11) ◽  
pp. 1150-1163 ◽  
Author(s):  
Ryo Koyama ◽  
Tomoya Arai ◽  
Marie Kijima ◽  
Shoko Sato ◽  
Shigetoshi Miura ◽  
...  
Keyword(s):  
Dnase I ◽  
Dnase Γ ◽  
Caspase Activated Dnase

scholarly journals Specific endocytosis and degradation of naked DNA in the endocardial cells of cod (Gadus morhua L.)

2007 ◽  
Vol 210 (12) ◽  
pp. 2091-2103 ◽  
Author(s):  
T. Seternes ◽  
T. C. Tonheim ◽  
M. Lovoll ◽  
J. Bogwald ◽  
R. A. Dalmo
Keyword(s):  
Gadus Morhua ◽  
Naked Dna
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