Accumulation of Human Apolipoprotein-E in Rat Plasma After in vivo Intramuscular Injection of Naked DNA

1994 ◽  
Vol 200 (1) ◽  
pp. 298-305 ◽  
Author(s):  
V.M. Fazio ◽  
S. Fazio ◽  
M. Rinaldi ◽  
M.V. Catani ◽  
S. Zotti ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Intramuscular Injection ◽  
Rat Plasma ◽  
Human Apolipoprotein ◽  
Naked Dna

4.P.390 Human apolipoprotein E protects against the deleterious effects of bacterial lipopolysaccharide in rats in vivo

1997 ◽  
Vol 134 (1-2) ◽  
pp. 379
Author(s):  
P.C.N. Rensen ◽  
M. van Oosten ◽  
E. van de Bilt ◽  
M. van Eck ◽  
J. Kuiper ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Bacterial Lipopolysaccharide ◽  
Human Apolipoprotein

scholarly journals In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e38013 ◽  
Author(s):  
Kristin R. Wildsmith ◽  
Jacob M. Basak ◽  
Bruce W. Patterson ◽  
Yuriy Pyatkivskyy ◽  
Jungsu Kim ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Turnover Rates ◽  
Human Apolipoprotein ◽  
Fractional Turnover

P3-296: Assessment of human apolipoprotein E and Aβ clearance rate in vivo through use of stable isotope-labeling and tandem mass spectrometry

2008 ◽  
Vol 4 ◽  
pp. T609-T609
Author(s):  
Jungsu Kim ◽  
Jacob Basak ◽  
Kristin R. Wildsmith ◽  
Hong Jiang ◽  
Kwasi G. Mawuenyega ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Stable Isotope ◽  
Tandem Mass Spectrometry ◽  
Apolipoprotein E ◽  
Clearance Rate ◽  
Isotope Labeling ◽  
Tandem Mass ◽  
Human Apolipoprotein ◽  
Aβ Clearance

scholarly journals Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo

2013 ◽  
Vol 28 (2) ◽  
pp. 236-245 ◽  
Author(s):  
Marco Dieckmann ◽  
F Timo Beil ◽  
Brigitte Mueller ◽  
Alexander Bartelt ◽  
Robert P Marshall ◽  
...  
Keyword(s):  
Bone Mass ◽  
Apolipoprotein E ◽  
Human Apolipoprotein

scholarly journals Correction: In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
Author(s):  
Kristin R. Wildsmith ◽  
Jacob M. Basak ◽  
Bruce W. Patterson ◽  
Yuriy Pyatkivskyy ◽  
Jungsu Kim ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Turnover Rates ◽  
Human Apolipoprotein ◽  
Fractional Turnover

Adenoviral mediated gene transfer of human apolipoprotein E to the vascular wall in vivo

1995 ◽  
Vol 115 ◽  
pp. S25
Author(s):  
T. O'Brien ◽  
R. Quan ◽  
D. Spector ◽  
S. Lauer ◽  
K. Nguyen ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Apolipoprotein E ◽  
Vascular Wall ◽  
Human Apolipoprotein

Analysis of the structure and function relationship of human apolipoprotein E in vivo, using adenovirus‐mediated gene transfer

2001 ◽  
Vol 15 (9) ◽  
pp. 1598-1600 ◽  
Author(s):  
Kyriakos E. Kypreos ◽  
Bas Teusink ◽  
K. O. Willems Dijk ◽  
Louis M. Havekes ◽  
Vassilis I. Zannis
Keyword(s):  
Gene Transfer ◽  
Apolipoprotein E ◽  
Structure And Function ◽  
Human Apolipoprotein ◽  
Function Relationship ◽  
Structure And Function Relationship ◽  
And Function ◽  
Relationship Of

scholarly journals Human Apolipoprotein E Isoforms Influence Neurite Outgrowth and Regeneration In Vitro and In Vivo

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Rachel Susanne Jolly Maggard ◽  
Christopher M. Calulot ◽  
Lydia E. Hager ◽  
Kyle J. Ritter ◽  
Brittany N. Turba ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Neurite Outgrowth ◽  
Human Apolipoprotein ◽  
Regeneration In Vitro

Anti-thrombotic Effect of a PAI-1 Inhibitor in Rats Given Endotoxin

1996 ◽  
Vol 75 (01) ◽  
pp. 118-126 ◽  
Author(s):  
T Abrahamsson ◽  
V Nerme ◽  
M Strömqvist ◽  
B Åkerblom ◽  
A Legnehed ◽  
...  
Keyword(s):  
Plasminogen Activator Inhibitor ◽  
Rat Plasma ◽  
Clot Lysis ◽  
Fibrin Deposition ◽  
Plasminogen Activator Inhibitor 1 ◽  
Fab Fragment ◽  
Dose Dependent Decrease ◽  
Pai 1

SummaryThe aim of this study was to investigate the anti-thrombotic effects of an inhibitor of the plasminogen activator inhibitor-1 (PAI-1) in rats given endotoxin. In studies in vitro, PRAP-1, a Fab-fragment of a polyclonal antibody against human PAI-1, was shown to inhibit PAI-1 activity in rat plasma as well as to stimulate clot-lysis of the euglobulin fraction derived from rat plasma. Endotoxin administered to anaesthetised rats produced a marked increase in plasma PAI-1 activity. To study fibrin formation and lysis in vivo after intravenous (i. v.) injection of the coagulant enzyme batroxobin, 125I-fibrinogen was administered to the animals. The thrombi formed by batroxobin were rapidly lysed in control animals, while the rate of lysis was markedly attenuated in rats given endotoxin. PRAP-1 was administered i.v. (bolus + infusion) to rats given endotoxin and batroxobin and the PAI-1 inhibitor caused a dose-dependent decrease in the 125I-fibrin deposition in the lungs. An immunohistochemical technique was used to confirm this decrease in density of fibrin clots in the tissue. Furthermore, PRAP-1 decreased plasma PAI-1 activity in the rats and this reduction was correlated to the decrease in lung 125I-fibrin deposition at the corresponding time point. It is concluded that in this experimental model the PAI-1 antibody PRAP-1 may indeed inhibit thrombosis in animals exposed to endotoxin.

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