Amyloid fibril aggregation: An insight into the underwater adhesion of barnacle cement

2017 ◽  
Vol 493 (1) ◽  
pp. 654-659 ◽  
Author(s):  
Xingping Liu ◽  
Chao Liang ◽  
Xinkang Zhang ◽  
Jianyong Li ◽  
Jingyun Huang ◽  
...  
Keyword(s):  
Amyloid Fibril ◽  
Underwater Adhesion ◽  
Fibril Aggregation ◽  
Insight Into ◽  
Barnacle Cement

Effective inhibition of insulin amyloid fibril aggregation by nickel(II) complexes containing heterocyclic thiosemicarbazones

2021 ◽  
Author(s):  
Kannayiram Gomathi ◽  
Jebiti Haribabu ◽  
Sivaraj Saranya ◽  
Dasararaju Gayathri ◽  
Kumaramangalam Jeyalakshmi ◽  
...  
Keyword(s):  
Amyloid Fibril ◽  
Effective Inhibition ◽  
Fibril Aggregation

Soy isoflavones as potential inhibitors of Alzheimer ß-amyloid fibril aggregation in vitro

2010 ◽  
Vol 43 (8) ◽  
pp. 2176-2178 ◽  
Author(s):  
Caroline Henry-Vitrac ◽  
Hervé Berbille ◽  
Jean-Michel Mérillon ◽  
Xavier Vitrac
Keyword(s):  
Amyloid Fibril ◽  
Soy Isoflavones ◽  
Potential Inhibitors ◽  
Fibril Aggregation

scholarly journals Cell-derived hexameric β-amyloid: a novel insight into composition, self-assembly and nucleating properties

2020 ◽  
Author(s):  
Devkee M Vadukul ◽  
Céline Vrancx ◽  
Pierre Burguet ◽  
Sabrina Contino ◽  
Nuria Suelves ◽  
...  
Keyword(s):  
Self Assembly ◽  
Critical Nucleus ◽  
Amyloid Fibril ◽  
Amyloid Β ◽  
Aβ Peptide ◽  
Amyloid A ◽  
Amyloid Fibril Formation ◽  
Secretase Activity ◽  
Β Amyloid ◽  
Insight Into

A key hallmark of Alzheimer's disease (AD) is the extracellular deposition of amyloid plaques composed primarily of the amyloidogenic amyloid-β (Aβ) peptide. The Aβ peptide is a product of sequential cleavage of the Amyloid Precursor Protein (APP), the first step of which gives rise to a C-terminal Fragment (C99). Cleavage of C99 by γ-secretase activity releases Aβ of several lengths and the Aβ42 isoform in particular has been identified as being neurotoxic. The misfolding of Aβ leads to subsequent amyloid fibril formation by nucleated polymerisation. This requires an initial and critical nucleus for self-assembly. Here, we identify and characterise the composition and self-assembly properties of cell-derived hexameric Aβ42 and show its nucleating properties which are dependent on the Aβ monomer availability. Identification of nucleating assemblies that contribute to self-assembly in this way may serve as therapeutic targets to prevent the formation of toxic oligomers.

scholarly journals A lattice-gas model for amyloid fibril aggregation

2011 ◽  
Vol 94 (6) ◽  
pp. 68006 ◽  
Author(s):  
Liu Hong ◽  
Xianghong Qi ◽  
Yang Zhang
Keyword(s):  
Lattice Gas ◽  
Amyloid Fibril ◽  
Lattice Gas Model ◽  
Fibril Aggregation
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