Cooperation of Rho family proteins Rac1 and Cdc42 in cartilage development and calcified tissue formation

2018 ◽  
Vol 500 (3) ◽  
pp. 525-529 ◽  
Author(s):  
Mikiko Ikehata ◽  
Atsushi Yamada ◽  
Koji Fujita ◽  
Yuko Yoshida ◽  
Tadashi Kato ◽  
...  
Keyword(s):  
Tissue Formation ◽  
Cartilage Development ◽  
Calcified Tissue ◽  
Rho Family ◽  
Rho Family Proteins

New insight into the molecular switch mechanism of human Rho family proteins: shifting a paradigm

2013 ◽  
Vol 394 (1) ◽  
pp. 89-95 ◽  
Author(s):  
Mamta Jaiswal ◽  
Eyad Kalawy Fansa ◽  
Radovan Dvorsky ◽  
Mohammad Reza Ahmadian
Keyword(s):  
Quantitative Analysis ◽  
Bound State ◽  
Molecular Switch ◽  
Nucleotide Exchange ◽  
Gtp Binding ◽  
Switch Mechanism ◽  
Rho Family ◽  
Rho Family Proteins ◽  
Insight Into ◽  
Made In

Abstract Major advances have been made in understanding the structure, function and regulation of the small GTP-binding proteins of the Rho family and their involvement in multiple cellular process and disorders. However, intrinsic nucleotide exchange and hydrolysis reactions, which are known to be fundamental to Rho family proteins, have been partially investigated in the case of RhoA, Rac1 and Cdc42, but for others not at all. Here we present a comprehensive and quantitative analysis of the molecular switch functions of 15 members of the Rho family that enabled us to propose an active GTP-bound state for the rather uncharacterized isoforms RhoD and Rif under equilibrium and quiescent conditions.

scholarly journals Rho Family Proteins: Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion (Adv. Sci. 14/2020)

2020 ◽  
Vol 7 (14) ◽  
pp. 2070079
Author(s):  
Zhongya Sun ◽  
Hao Zhang ◽  
Yuanyuan Zhang ◽  
Liping Liao ◽  
Wen Zhou ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Covalent Inhibitors ◽  
Rho Family ◽  
Rho Family Proteins

Role of Rho-family proteins in cell adhesion and cancer

2003 ◽  
Vol 15 (5) ◽  
pp. 583-589 ◽  
Author(s):  
Angeliki Malliri ◽  
John G Collard
Keyword(s):  
Cell Adhesion ◽  
Rho Family ◽  
Rho Family Proteins

scholarly journals Role of Rho Family Proteins in Phospholipase D Activation by Growth Factors

1997 ◽  
Vol 272 (3) ◽  
pp. 1615-1620 ◽  
Author(s):  
Jean A. Hess ◽  
Annette H. Ross ◽  
Rong-Guo Qiu ◽  
Marc Symons ◽  
John H. Exton
Keyword(s):  
Growth Factors ◽  
Phospholipase D ◽  
Rho Family ◽  
Rho Family Proteins

scholarly journals Rho family proteins and Ras transformation: the RHOad less traveled gets congested

Oncogene ◽  
1998 ◽  
Vol 17 (11) ◽  
pp. 1415-1438 ◽  
Author(s):  
Irene M Zohn ◽  
Sharon L Campbell ◽  
Roya Khosravi-Far ◽  
Kent L Rossman ◽  
Channing J Der
Keyword(s):  
Rho Family ◽  
Rho Family Proteins

T-cadherin regulates microtubules and Rho family proteins

2006 ◽  
Vol 45 (3) ◽  
pp. e82-e83
Author(s):  
Talovskaya ◽  
Gorovoy ◽  
Parfyonova ◽  
Rubina ◽  
Tkachuk ◽  
...  
Keyword(s):  
Rho Family ◽  
Rho Family Proteins

Rho Family Proteins

2011 ◽  
pp. 3302-3308
Author(s):  
Channing J. Der
Keyword(s):  
Rho Family ◽  
Rho Family Proteins
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