Berberine-photodynamic induced apoptosis by activating endoplasmic reticulum stress-autophagy pathway involving CHOP in human malignant melanoma cells

2021 ◽  
Vol 552 ◽  
pp. 183-190
Author(s):  
Jiaping Fang ◽  
Xuan Huang ◽  
Yun Yang ◽  
Xiaotong Wang ◽  
Xin Liang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Malignant Melanoma ◽  
Endoplasmic Reticulum Stress ◽  
Melanoma Cells ◽  
Human Malignant Melanoma ◽  
Autophagy Pathway ◽  
Induced Apoptosis

scholarly journals Depolarization potentiates TRAIL-induced apoptosis in human melanoma cells: Role for ATP-sensitive K+ channels and endoplasmic reticulum stress

2012 ◽  
Vol 41 (2) ◽  
pp. 465-475 ◽  
Author(s):  
YOSHIHIRO SUZUKI ◽  
TOSHIO INOUE ◽  
MAYUMI MURAI ◽  
MIKI SUZUKI-KARASAKI ◽  
TOYOKO OCHIAI ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
K Channels ◽  
Human Melanoma Cells ◽  
Induced Apoptosis

scholarly journals Inhibition of Endoplasmic Reticulum Stress–Induced Apoptosis of Melanoma Cells by the ARC Protein

2008 ◽  
Vol 68 (3) ◽  
pp. 834-842 ◽  
Author(s):  
Li Hua Chen ◽  
Chen Chen Jiang ◽  
Ralph Watts ◽  
Rick F. Thorne ◽  
Kelly A. Kiejda ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Melanoma Cells ◽  
Induced Apoptosis

scholarly journals Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53

2009 ◽  
Vol 100 (2) ◽  
pp. 322-333 ◽  
Author(s):  
S C Naumann ◽  
W P Roos ◽  
E Jöst ◽  
C Belohlavek ◽  
V Lennerz ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Melanoma Cells ◽  
Human Malignant Melanoma ◽  
Induced Apoptosis

scholarly journals Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy

2019 ◽  
Author(s):  
Kotaro Makita ◽  
Hiroyuki Hara ◽  
Emiko Sano ◽  
Yutaka Okamoto ◽  
Yushi Ochiai ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Melanoma Cells ◽  
Interferon Β ◽  
Human Malignant Melanoma ◽  
Induced Apoptosis

Promotion of TRAIL/Apo2L‐induced apoptosis by low‐dose interferon‐β in human malignant melanoma cells

2019 ◽  
Vol 234 (8) ◽  
pp. 13510-13524 ◽  
Author(s):  
Akira Kazaana ◽  
Emiko Sano ◽  
Sodai Yoshimura ◽  
Kotaro Makita ◽  
Hiroyuki Hara ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Low Dose ◽  
Melanoma Cells ◽  
Interferon Β ◽  
Human Malignant Melanoma ◽  
Induced Apoptosis

Inhibition of MEK Sensitizes Human Melanoma Cells to Endoplasmic Reticulum Stress-Induced Apoptosis

2007 ◽  
Vol 67 (20) ◽  
pp. 9750-9761 ◽  
Author(s):  
Chen Chen Jiang ◽  
Li Hua Chen ◽  
Susan Gillespie ◽  
Yu Fang Wang ◽  
Kelly A. Kiejda ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells ◽  
Induced Apoptosis

scholarly journals Development of a Novel Experimental In Vitro Model of Isothiocyanate-induced Apoptosis in Human Malignant Melanoma Cells

2016 ◽  
Vol 36 (12) ◽  
pp. 6303-6310 ◽  
Author(s):  
THEODORA MANTSO ◽  
ARISTEIDIS P SFAKIANOS ◽  
AITHNE ATKINSON ◽  
IOANNIS ANESTOPOULOS ◽  
MELINA MITSIOGIANNI ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
In Vitro Model ◽  
Melanoma Cells ◽  
Human Malignant Melanoma ◽  
Vitro Model ◽  
Induced Apoptosis

Ferruginol induced apoptosis on SK-Mel-28 human malignant melanoma cells mediated through P-p38 and NF-κB

2018 ◽  
Vol 38 (2) ◽  
pp. 227-238 ◽  
Author(s):  
Y Jia ◽  
C Wu ◽  
B Zhang ◽  
Y Zhang ◽  
J Li
Keyword(s):  
Dna Damage ◽  
Malignant Melanoma ◽  
Caspase 3 ◽  
Nuclear Translocation ◽  
Annexin V ◽  
Melanoma Cells ◽  
Prolonged Treatment ◽  
Dependent Manner ◽  
Human Malignant Melanoma ◽  
Induced Apoptosis

In the present investigation, the antitumor effect of ferruginol (FGL) in SK-Mel-28 human malignant melanoma cells was studied. To investigate the cytotoxic property of FGL, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used. Results revealed that prolonged treatment duration decreases the IC25, IC50, and IC75 concentrations of FGL. The cytotoxicity was further confirmed by lactate dehydrogenase assay. As evident from comet assay, FGL induces DNA damage in a dose-dependent manner. Annexin V and 7-ADD assays showed that FGL-induced DNA damage triggers apoptosis-mediated cell death as confirmed by caspase-3 activity assay. As seen through Western blotting, FGL increases phosphorylation of p38 and nuclear translocation of NF-κB. Further, it was observed that p38 phosphorylation is responsible for NF-κB translocation to the nucleus. Further, inhibition of p38 phosphorylation and translocation of NF-κB decrease caspase-3 activity. The above finding confirms that caspase-3 activation is mediated through P-p38 and nuclear translocation of NF-κB. The present findings indicate that FGL significantly suppresses the proliferation of SK-Mel-28 cells in a dose- and time-dependent manner through induction of apoptosis. Furthermore, FGL executes apoptosis through phosphorylation of key protein such as p38 and translocation of NF-κB into the nucleus.

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