scholarly journals A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer

2021 ◽  
Author(s):  
Jin Lee ◽  
Xiaoxi Chen ◽  
Yuming Wang ◽  
Tatsunori Nishimura ◽  
Mengjiao Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Combination Treatment ◽  
Carbon Metabolism ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1 ◽  
Rational Combination ◽  
One Carbon Metabolism

Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer

2010 ◽  
Vol 38 (8) ◽  
pp. 4893-4901 ◽  
Author(s):  
Shaik Mohammad Naushad ◽  
Addepalli Pavani ◽  
Raghunadha Rao Digumarti ◽  
Suryanarayana Raju Gottumukkala ◽  
Vijay Kumar Kutala
Keyword(s):  
Breast Cancer ◽  
Carbon Metabolism ◽  
Epistatic Interactions ◽  
One Carbon Metabolism

scholarly journals B-Vitamin Intake, One-Carbon Metabolism, and Survival in a Population-Based Study of Women with Breast Cancer

2008 ◽  
Vol 17 (8) ◽  
pp. 2109-2116 ◽  
Author(s):  
Xinran Xu ◽  
Marilie D. Gammon ◽  
James G. Wetmur ◽  
Patrick T. Bradshaw ◽  
Susan L. Teitelbaum ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carbon Metabolism ◽  
Population Based ◽  
Population Based Study ◽  
Vitamin Intake ◽  
One Carbon Metabolism ◽  
B Vitamin

Checkpoint Kinase 1 Expression Predicts Poor Prognosis in Nigerian Breast Cancer Patients

2017 ◽  
Vol 22 (1) ◽  
pp. 79-90 ◽  
Author(s):  
Henry Okuchukwu Ebili ◽  
Victoria O. Iyawe ◽  
Kikelomo Rachel Adeleke ◽  
Babatunde Abayomi Salami ◽  
Adekunbiola Aina Banjo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Breast Cancer Patients ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1

scholarly journals Checkpoint Kinase 1 (CHK1) Inhibition Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Proton Irradiation via Rad51 Downregulation

2020 ◽  
Vol 21 (8) ◽  
pp. 2691 ◽  
Author(s):  
Changhoon Choi ◽  
Won Kyung Cho ◽  
Sohee Park ◽  
Sung-Won Shin ◽  
Won Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Proton Irradiation ◽  
Treatment Options ◽  
Annexin V ◽  
Proton Beam Therapy ◽  
X Rays ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1

Due to a superior dose conformity to the target, proton beam therapy (PBT) continues to rise in popularity. Recently, considerable efforts have been directed toward discovering treatment options for use in combination with PBT. This study aimed to investigate the targeting of checkpoint kinase 1 (CHK1), a critical player regulating the G2/M checkpoint, as a promising strategy to potentiate PBT in human triple-negative breast cancer (TNBC) cells. Protons induced cell-cycle arrest at the G2/M checkpoint more readily in response to increased CHK1 activation than X-rays. A clonogenic survival assay revealed that CHK1 inhibition using PF-477736 or small interfering RNA (siRNA) enhanced the sensitivity toward protons to a greater extent than toward X-rays. Western blotting demonstrated that PF-477736 treatment in the background of proton irradiation increased the pro-apoptotic signaling, which was further supported by flow cytometry using annexin V. Immunofluorescence revealed that proton-induced DNA double-strand breaks (DSBs) were further enhanced by PF-477736, which was linked to the downregulation of Rad51, essential for the homologous recombination repair of DSBs. Direct inactivation of Rad51 resulted in enhanced proton sensitization. Collectively, these data suggest that targeting CHK1 may be a promising approach for improving PBT efficacy in the treatment of TNBC.

Association of Polymorphisms in One-Carbon Metabolism Genes and Postmenopausal Breast Cancer Incidence

2007 ◽  
Vol 16 (6) ◽  
pp. 1140-1147 ◽  
Author(s):  
Victoria L. Stevens ◽  
Marjorie L. McCullough ◽  
Alexandre L. Pavluck ◽  
Jeffrey T. Talbot ◽  
Heather S. Feigelson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Incidence ◽  
Carbon Metabolism ◽  
Breast Cancer Incidence ◽  
Postmenopausal Breast Cancer ◽  
One Carbon Metabolism

scholarly journals Population-level diversity in the association of genetic polymorphisms of one-carbon metabolism with breast cancer risk

2016 ◽  
Vol 7 (4) ◽  
pp. 279-290 ◽  
Author(s):  
Shaik Mohammad Naushad ◽  
Chandrasekhar Divya ◽  
M. Janaki Ramaiah ◽  
Tajamul Hussain ◽  
Salman A. Alrokayan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Carbon Metabolism ◽  
Population Level ◽  
One Carbon Metabolism
Sign in / Sign up

Export Citation Format

Share Document