Cell cycle dependence on the mevalonate pathway: role of cholesterol and non-sterol isoprenoids

2021 ◽  
pp. 114623
Author(s):  
Miguel A. Lasunción ◽  
Javier Martínez-Botas ◽  
Covadonga Martín-Sánchez ◽  
Rebeca Busto ◽  
Diego Gómez-Coronado
1995 ◽  
Vol 489 (2) ◽  
pp. 455-471 ◽  
Author(s):  
A Arcangeli ◽  
L Bianchi ◽  
A Becchetti ◽  
L Faravelli ◽  
M Coronnello ◽  
...  

1984 ◽  
Vol 98 (3) ◽  
pp. 491 ◽  
Author(s):  
R. A. Read ◽  
M. H. Fox ◽  
J. S. Bedford

2020 ◽  
Vol 21 (23) ◽  
pp. 9166
Author(s):  
Shigeru Hanamata ◽  
Takamitsu Kurusu ◽  
Kazuyuki Kuchitsu

Autophagy is ubiquitous in eukaryotic cells and plays an essential role in stress adaptation and development by recycling nutrients and maintaining cellular homeostasis. However, the dynamics and regulatory mechanisms of autophagosome formation during the cell cycle in plant cells remain poorly elucidated. We here analyzed the number of autophagosomes during cell cycle progression in synchronized tobacco BY-2 cells expressing YFP-NtATG8a as a marker for the autophagosomes. Autophagosomes were abundant in the G2 and G1 phases of interphase, though they were much less abundant in the M and S phases. Autophagosomes drastically decreased during the G2/M transition, and the CDK inhibitor roscovitine inhibited the G2/M transition and the decrease in autophagosomes. Autophagosomes were rapidly increased by a proteasome inhibitor, MG-132. MG-132-induced autophagosome formation was also markedly lower in the M phases than during interphase. These results indicate that the activity of autophagosome formation is differently regulated at each cell cycle stage, which is strongly suppressed during mitosis.


2004 ◽  
Vol 279 (51) ◽  
pp. 52881-52892 ◽  
Author(s):  
Alex D. Manguikian ◽  
Suzanne E. Barbour

PROTEOMICS ◽  
2018 ◽  
Vol 18 (11) ◽  
pp. 1700442 ◽  
Author(s):  
Tingting Jiang ◽  
Michael E. Hoover ◽  
Matthew V. Holt ◽  
Michael A. Freitas ◽  
Alan G. Marshall ◽  
...  

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