Long non-coding RNA 657 suppresses hepatocellular carcinoma cell growth by acting as a molecular sponge of miR-106a-5p to regulate PTEN expression

2017 ◽  
Vol 92 ◽  
pp. 34-42 ◽  
Author(s):  
Bingren Hu ◽  
Huajie Cai ◽  
Ru Zheng ◽  
Shouzhang Yang ◽  
Zhenxu Zhou ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Carcinoma Cell ◽  
Pten Expression ◽  
Non Coding Rna ◽  
Hepatocellular Carcinoma Cell ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma

Tumor Biology ◽  
2017 ◽  
Vol 39 (2) ◽  
pp. 101042831769099 ◽  
Author(s):  
Yichao Mo ◽  
Yaoyong Lu ◽  
Peng Wang ◽  
Simin Huang ◽  
Longguang He ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Cell Cycle Progression ◽  
Carcinoma Cell ◽  
Xist Expression ◽  
Cycle Progression ◽  
Non Coding Rna ◽  
Direct Target ◽  
Hepatocellular Carcinoma Cell ◽  
Long Non Coding Rna

Abnormal expression of long non-coding RNA often contributes to unrestricted growth of cancer cells. Long non-coding RNA XIST expression is upregulated in several cancers; however, its modulatory mechanisms have not been reported in hepatocellular carcinoma. In this study, we found that XIST expression was significantly increased in hepatocellular carcinoma tissues and cell lines. XIST promoted cell cycle progression from the G1 phase to the S phase and protected cells from apoptosis, which contributed to hepatocellular carcinoma cell growth. In addition, we revealed that there was reciprocal repression between XIST and miR-139-5p. PDK1 was identified as a direct target of miR-139-5p. We proposed that XIST was responsible for hepatocellular carcinoma cell proliferation, and XIST exerted its function through the miR-139-5p/PDK1 axis.

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