Sarcoid-derived fibroblasts: Links between genomic instability, energy metabolism and senescence

Biochimie ◽  
2014 ◽  
Vol 97 ◽  
pp. 163-172 ◽  
Author(s):  
Leszek Potocki ◽  
Anna Lewinska ◽  
Jolanta Klukowska-Rötzler ◽  
Anna Bielak-Zmijewska ◽  
Wioleta Grabowska ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Genomic Instability ◽  
Instability Energy

Mitochondrial matrix calcium ions regulate energy production in myocardium: A cytochemical study

1990 ◽  
Vol 48 (2) ◽  
pp. 166-167
Author(s):  
W.A. Jacob ◽  
R. Hertsens ◽  
A. Van Bogaert ◽  
M. De Smet
Keyword(s):  
Energy Metabolism ◽  
Calcium Ions ◽  
Energy Production ◽  
Regulation Of Respiration ◽  
Free Calcium ◽  
Mitochondrial Matrix ◽  
Cytochemical Study ◽  
Nmr Techniques

In the past most studies of the control of energy metabolism focus on the role of the phosphorylation potential ATP/ADP.Pi on the regulation of respiration. Studies using NMR techniques have demonstrated that the concentrations of these compounds for oxidation phosphorylation do not change appreciably throughout the cardiac cycle and during increases in cardiac work. Hence regulation of energy production by calcium ions, present in the mitochondrial matrix, has been the object of a number of recent studies.Three exclusively intramitochondnal dehydrogenases are key enzymes for the regulation of oxidative metabolism. They are activated by calcium ions in the low micromolar range. Since, however, earlier estimates of the intramitochondnal calcium, based on equilibrium thermodynamic considerations, were in the millimolar range, a physiological correlation was not evident. The introduction of calcium-sensitive probes fura-2 and indo-1 made monitoring of free calcium during changing energy metabolism possible. These studies were performed on isolated mitochondria and extrapolation to the in vivo situation is more or less speculative.

Genomic instability and radiation mutagenesis

1996 ◽  
Vol 93 ◽  
pp. 157-164 ◽  
Author(s):  
JB Little ◽  
C Li ◽  
H Nagasawa ◽  
T Pfenning ◽  
H Vetrovs
Keyword(s):  
Genomic Instability

Regulation of energy metabolism in hepatocytes with induced steatosis

2015 ◽  
Vol 53 (01) ◽  
Author(s):  
K Schönefeld ◽  
M Matz-Soja ◽  
J Böttger ◽  
P Seibel ◽  
R Gebhardt
Keyword(s):  
Energy Metabolism

Dysregulation of energy metabolism in obesity and its implications for cancer

2016 ◽  
Vol 02 (03) ◽  
pp. 133-142
Author(s):  
Andrew Hoffman ◽  
Lauren Battaglia ◽  
Michael DeStefano ◽  
Emine Abali
Keyword(s):  
Energy Metabolism
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