scholarly journals The effect of FGF-1 loaded alginate microbeads on neovascularization and adipogenesis in a vascular pedicle model of adipose tissue engineering

Biomaterials ◽  
2010 ◽  
Vol 31 (10) ◽  
pp. 2816-2826 ◽  
Author(s):  
Monica L. Moya ◽  
Ming-Huei Cheng ◽  
Jung-Ju Huang ◽  
Megan E. Francis-Sedlak ◽  
Shu-wei Kao ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Adipose Tissue ◽  
Vascular Pedicle ◽  
Adipose Tissue Engineering

The tissue-engineered breast

2021 ◽  
pp. 1115-1120
Author(s):  
Wayne Morrison
Keyword(s):  
Tissue Engineering ◽  
Adipose Tissue ◽  
Stem Cell Differentiation ◽  
Vascular Pedicle ◽  
Human Trial ◽  
Fat Transfer ◽  
Adipose Tissue Engineering ◽  
Proof Of Principle

The adipose tissue engineering paradigm of in vitro cell-seeded scaffolds subsequently implanted in vivo failed because of inadequate vascularization. Consequently, entirely in vivo models of tissue engineering are being trialled where angiogenic growth is stimulated in unison with expansion of implanted cells and matrices. In animals, impressive amounts of fat and fibroblastic tissue have been grown by matrix induction of preadipocytes or by redirecting a vascular pedicle with fat into a sealed chamber space and proof of principle shown in a human trial. The models are cumbersome limiting clinical translation and currently direct fat transfer by injection is simpler. Unlike true tissue engineering there is, however, no net gain of tissue and even when ‘successful’ it is debated whether the graft survives or is replaced by newly regenerated adipocytes. Research focuses on stem cell differentiation, cell survival, and matrix and biomechanical manipulations.

Adipose tissue engineering with naturally derived scaffolds and adipose-derived stem cells

Biomaterials ◽  
2007 ◽  
Vol 28 (26) ◽  
pp. 3834-3842 ◽  
Author(s):  
Lauren Flynn ◽  
Glenn D. Prestwich ◽  
John L. Semple ◽  
Kimberly A. Woodhouse
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Adipose Tissue ◽  
Adipose Derived Stem Cells ◽  
Adipose Tissue Engineering

In Vitro Adipose Tissue Engineering Using an Electrospun Nanofibrous Scaffold

2008 ◽  
Vol 61 (5) ◽  
pp. 566-571 ◽  
Author(s):  
Rabie M. Shanti ◽  
Sasa Janjanin ◽  
Wan-Ju Li ◽  
Leon J. Nesti ◽  
Michael B. Mueller ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Adipose Tissue ◽  
Nanofibrous Scaffold ◽  
Adipose Tissue Engineering
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