Development of novel carbazole derivatives with effective multifunctional action against Alzheimer’s diseases: Design, synthesis, in silico, in vitro and in vivo investigation

2020 ◽  
Vol 95 ◽  
pp. 103524 ◽  
Author(s):  
Chandra Bhushan Mishra ◽  
Siddharth Gusain ◽  
Shruti Shalini ◽  
Shikha Kumari ◽  
Amresh Prakash ◽  
...  
Keyword(s):  
In Silico ◽  
Design Synthesis ◽  
Carbazole Derivatives ◽  
Alzheimer’S Diseases ◽  
Alzheimer's Diseases

N-pyridin-2-yl benzamide analogues as allosteric activators of glucokinase: Design, synthesis, in vitro,in silico and in vivo evaluation

2018 ◽  
Vol 93 (3) ◽  
pp. 364-372 ◽  
Author(s):  
Ajmer Singh Grewal ◽  
Rajeev Kharb ◽  
Deo Nandan Prasad ◽  
Jagdeep Singh Dua ◽  
Viney Lather
Keyword(s):  
In Silico ◽  
In Vivo Evaluation ◽  
Design Synthesis

Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents

2020 ◽  
Vol 186 ◽  
pp. 111863 ◽  
Author(s):  
Muhammad Saeed Jan ◽  
Sajjad Ahmad ◽  
Fida Hussain ◽  
Ashfaq Ahmad ◽  
Fawad Mahmood ◽  
...  
Keyword(s):  
In Silico ◽  
Design Synthesis ◽  
In Silico Studies ◽  
Anti Inflammatory

scholarly journals Retinal and Brain Organoids: Bridging the Gap Between in vivo Physiology and in vitro Micro-Physiology for the Study of Alzheimer’s Diseases

2020 ◽  
Vol 14 ◽  
Author(s):  
Carlo Brighi ◽  
Federica Cordella ◽  
Luigi Chiriatti ◽  
Alessandro Soloperto ◽  
Silvia Di Angelantonio
Keyword(s):  
Alzheimer’S Diseases ◽  
Alzheimer's Diseases

scholarly journals Design, Synthesis, Antihyperglycemic Studies, and Docking Simulations of Benzimidazole-Thiazolidinedione Hybrids

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Abraham Gutierréz-Hernández ◽  
Yelzyn Galván-Ciprés ◽  
Elix Alberto Domínguez-Mendoza ◽  
Yoshajandith Aguirre-Vidal ◽  
Samuel Estrada-Soto ◽  
...  
Keyword(s):  
Mrna Expression ◽  
In Silico ◽  
Knoevenagel Condensation ◽  
Binding Mode ◽  
Spectral Studies ◽  
Design Synthesis ◽  
Docking Simulations ◽  
Step Procedure

A simple and cheap three-step procedure for the synthesis of three (5Z)-5-[3(4)-(1H-benzimidazol-2-ylmethoxy)benzylidene]-1,3-thiazolidine-2,4-diones has been described via a SN2 reaction of generally recognized as safe hydroxybenzaldehydes and 2-(chloromethyl)-1H-benzimidazole, followed by a Knoevenagel condensation with thiazolidine-2,4-dione in moderated yields. All the newly synthesized compounds were characterized using analytical and spectral studies. In vitro treatment on adipocytes with compounds increased the mRNA expression of two proteins recognized as strategic targets in diabetes: PPARγ and GLUT-4. In silico studies were conducted in order to explain the interaction binding mode of the synthesized compounds on PPARγ. In vivo studies confirmed that compounds 1–3 have robust antihyperglycemic action linked to insulin sensitization mechanisms. The present study provides three compounds with a promising antidiabetic action.

Design, synthesis, in-vitro thymidine phosphorylase inhibition, in-vivo antiangiogenic and in-silico studies of C-6 substituted dihydropyrimidines

2018 ◽  
Vol 80 ◽  
pp. 99-111 ◽  
Author(s):  
Fatima Iftikhar ◽  
Farhana Yaqoob ◽  
Nida Tabassum ◽  
Muhammad Saeed Jan ◽  
Abdul Sadiq ◽  
...  
Keyword(s):  
In Silico ◽  
Thymidine Phosphorylase ◽  
Design Synthesis ◽  
In Silico Studies

2-Furoic piperazide derivatives as promising drug candidates of type 2 diabetes and Alzheimer’s diseases: In vitro and in silico studies

2018 ◽  
Vol 77 ◽  
pp. 72-86 ◽  
Author(s):  
Muhammad Athar Abbasi ◽  
Mubashir Hassan ◽  
Aziz ur-Rehman ◽  
Sabahat Zahra Siddiqui ◽  
Ghulam Hussain ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
In Silico ◽  
Drug Candidates ◽  
In Silico Studies ◽  
Alzheimer’S Diseases ◽  
Alzheimer's Diseases

Design, synthesis, in vivo and in vitro studies of 1,2,3,4-tetrahydro-9H-carbazole derivatives, highly selective and potent butyrylcholinesterase inhibitors

2019 ◽  
Vol 24 (1) ◽  
pp. 211-223 ◽  
Author(s):  
Roshanak Ghobadian ◽  
Roghaieh Esfandyari ◽  
Hamid Nadri ◽  
Alireza Moradi ◽  
Mohammad Mahdavi ◽  
...  
Keyword(s):  
In Vitro Studies ◽  
Design Synthesis ◽  
Carbazole Derivatives
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