scholarly journals Retinal and Brain Organoids: Bridging the Gap Between in vivo Physiology and in vitro Micro-Physiology for the Study of Alzheimer’s Diseases

2020 ◽  
Vol 14 ◽  
Author(s):  
Carlo Brighi ◽  
Federica Cordella ◽  
Luigi Chiriatti ◽  
Alessandro Soloperto ◽  
Silvia Di Angelantonio
Keyword(s):  
Alzheimer’S Diseases ◽  
Alzheimer's Diseases

scholarly journals Mitochondria-Targeted Protective Compounds in Parkinson’s and Alzheimer’s Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-30 ◽  
Author(s):  
Carlos Fernández-Moriano ◽  
Elena González-Burgos ◽  
M. Pilar Gómez-Serranillos
Keyword(s):  
Mitochondrial Dysfunction ◽  
Therapeutic Strategies ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Cellular Energy ◽  
Alzheimer’S Diseases ◽  
Atp Regulation ◽  
Alzheimer's Diseases

Mitochondria are cytoplasmic organelles that regulate both metabolic and apoptotic signaling pathways; their most highlighted functions include cellular energy generation in the form of adenosine triphosphate (ATP), regulation of cellular calcium homeostasis, balance between ROS production and detoxification, mediation of apoptosis cell death, and synthesis and metabolism of various key molecules. Consistent evidence suggests that mitochondrial failure is associated with early events in the pathogenesis of ageing-related neurodegenerative disorders including Parkinson’s disease and Alzheimer’s disease. Mitochondria-targeted protective compounds that prevent or minimize mitochondrial dysfunction constitute potential therapeutic strategies in the prevention and treatment of these central nervous system diseases. This paper provides an overview of the involvement of mitochondrial dysfunction in Parkinson’s and Alzheimer’s diseases, with particular attention toin vitroandin vivostudies on promising endogenous and exogenous mitochondria-targeted protective compounds.

2-Furoic piperazide derivatives as promising drug candidates of type 2 diabetes and Alzheimer’s diseases: In vitro and in silico studies

2018 ◽  
Vol 77 ◽  
pp. 72-86 ◽  
Author(s):  
Muhammad Athar Abbasi ◽  
Mubashir Hassan ◽  
Aziz ur-Rehman ◽  
Sabahat Zahra Siddiqui ◽  
Ghulam Hussain ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
In Silico ◽  
Drug Candidates ◽  
In Silico Studies ◽  
Alzheimer’S Diseases ◽  
Alzheimer's Diseases

Induction and Differentiation of Dental Epithelium in Vivo and in Vitro

1982 ◽  
Vol 40 ◽  
pp. 142-145
Author(s):  
E. J. Kollar
Keyword(s):  
Connective Tissue ◽  
Oral Mucosa ◽  
Basal Lamina ◽  
Functional Derivatives ◽  
Specific Source ◽  
Dental Epithelium ◽  
Connective Tissue Stroma

The differentiation and maintenance of many specialized epithelial structures are dependent on the underlying connective tissue stroma and on an intact basal lamina. These requirements are especially stringent in the development and maintenance of the skin and oral mucosa. The keratinization patterns of thin or thick cornified layers as well as the appearance of specialized functional derivatives such as hair and teeth can be correlated with the specific source of stroma which supports these differentiated expressions.

Ultrastructural Correlations between Clonal Human Tumor Colonies and in Vivo Neoplasms

1982 ◽  
Vol 40 ◽  
pp. 210-211
Author(s):  
M.J. Murphy ◽  
R.R. Price ◽  
J.C. Sloman
Keyword(s):  
Cultured Cells ◽  
Human Tumor ◽  
Cell Type ◽  
Tumor Mass ◽  
Initial Cell ◽  
Cloning Assay ◽  
Human Tumor Cloning ◽  
The Relationship

The in vitro human tumor cloning assay originally described by Salmon and Hamburger has been applied recently to the investigation of differential anti-tumor drug sensitivities over a broad range of human neoplasms. A major problem in the acceptance of this technique has been the question of the relationship between the cultured cells and the original patient tumor, i.e., whether the colonies that develop derive from the neoplasm or from some other cell type within the initial cell population. A study of the ultrastructural morphology of the cultured cells vs. patient tumor has therefore been undertaken to resolve this question. Direct correlation was assured by division of a common tumor mass at surgical resection, one biopsy being fixed for TEM studies, the second being rapidly transported to the laboratory for culture.

Sign in / Sign up

Export Citation Format

Share Document