Discovery of N-(1,3,4-thiadiazol-2-yl)benzamide derivatives containing a 6,7-methoxyquinoline structure as novel EGFR/HER-2 dual-target inhibitors against cancer growth and angiogenesis

2021 ◽  
pp. 105469
Author(s):  
Xin-yang Li ◽  
De-pu Wang ◽  
Shuai Li ◽  
Wen-han Xue ◽  
Xin-hua Qian ◽  
...  
Keyword(s):  
Cancer Growth ◽  
Her 2 ◽  
Benzamide Derivatives ◽  
Dual Target

scholarly journals HER-2/neu Is Rate-limiting for Ovarian Cancer Growth

1997 ◽  
Vol 272 (47) ◽  
pp. 29482-29486 ◽  
Author(s):  
Hartmut Juhl ◽  
Sean G. Downing ◽  
Anton Wellstein ◽  
Frank Czubayko
Keyword(s):  
Ovarian Cancer ◽  
Cancer Growth ◽  
Her 2 ◽  
Rate Limiting

Extracellular matrix: the gatekeeper of tumor angiogenesis

2019 ◽  
Vol 47 (5) ◽  
pp. 1543-1555 ◽  
Author(s):  
Maurizio Mongiat ◽  
Simone Buraschi ◽  
Eva Andreuzzi ◽  
Thomas Neill ◽  
Renato V. Iozzo
Keyword(s):  
Extracellular Matrix ◽  
Tumor Angiogenesis ◽  
Signaling Cascades ◽  
Cancer Growth ◽  
Cell Behavior ◽  
Metastatic Progression ◽  
Surface Receptors ◽  
The Matrix ◽  
Multiple Signaling

Abstract The extracellular matrix is a network of secreted macromolecules that provides a harmonious meshwork for the growth and homeostatic development of organisms. It conveys multiple signaling cascades affecting specific surface receptors that impact cell behavior. During cancer growth, this bioactive meshwork is remodeled and enriched in newly formed blood vessels, which provide nutrients and oxygen to the growing tumor cells. Remodeling of the tumor microenvironment leads to the formation of bioactive fragments that may have a distinct function from their parent molecules, and the balance among these factors directly influence cell viability and metastatic progression. Indeed, the matrix acts as a gatekeeper by regulating the access of cancer cells to nutrients. Here, we will critically evaluate the role of selected matrix constituents in regulating tumor angiogenesis and provide up-to-date information concerning their primary mechanisms of action.

432: The Genetic Polymorphisms of HPC/ELAC2 and HER-2 Gene Associate with Japanese Sporadic Prostate Cancer

2004 ◽  
Vol 171 (4S) ◽  
pp. 114-114
Author(s):  
Akira Yokomizo ◽  
Hirofumi Koga ◽  
Koji Okumura ◽  
Tatsuo Konomoto ◽  
Taiji Tsukamoto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Genetic Polymorphisms ◽  
Her 2

Jab1 is overexpressed in human breast cancer and is a downstream target for HER-2/neu

2008 ◽  
Author(s):  
Ming-Chuan Hsu ◽  
Chee-Yin Chai ◽  
Ming-Feng Hou ◽  
Hui-Chiu Chang ◽  
Wan-Tzu Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Downstream Target ◽  
Her 2

Die Bedeutung des stabilisierenden Effekts von Lapatinib auf HER-2 an der Membranoberfläche von Mamma- bzw. Ovarialkarzinom-Linien

2009 ◽  
Vol 69 (03) ◽  
Author(s):  
V Porto ◽  
I Mutz-Dehbalaie ◽  
J Rössler ◽  
A Wiedemair ◽  
A Sapinsky ◽  
...  
Keyword(s):  
Her 2
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