T154. Functional Connectivity of the Anterior Cingulate Cortex in Veterans With Mild Traumatic Brain Injury

2019 ◽  
Vol 85 (10) ◽  
pp. S188-S189
Author(s):  
Chandni Sheth ◽  
Jadwiga Rogowska ◽  
Margaret Legarreta ◽  
Erin McGlade ◽  
Deborah Yurgelun-Todd
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Mild Traumatic Brain Injury ◽  
Cingulate Cortex ◽  
Anterior Cingulate

scholarly journals Functional connectivity of the anterior cingulate cortex in Veterans with mild traumatic brain injury

2021 ◽  
Vol 396 ◽  
pp. 112882 ◽  
Author(s):  
Chandni Sheth ◽  
Jadwiga Rogowska ◽  
Margaret Legarreta ◽  
Erin McGlade ◽  
Deborah Yurgelun-Todd
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Mild Traumatic Brain Injury ◽  
Cingulate Cortex ◽  
Anterior Cingulate

Increased myoinositol in the anterior cingulate cortex of veterans with a history of traumatic brain injury: a proton magnetic resonance spectroscopy study

2020 ◽  
Vol 123 (5) ◽  
pp. 1619-1629
Author(s):  
Chandni Sheth ◽  
Andrew P. Prescot ◽  
Margaret Legarreta ◽  
Perry F. Renshaw ◽  
Erin McGlade ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Anterior Cingulate Cortex ◽  
State Of The Art ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Resonance Spectroscopy ◽  
Spectroscopy Study ◽  
Magnetic Resonance Spectroscopy Study ◽  
History Of

In this study of veterans, we used a state-of-the-art neuroimaging tool to probe the neurometabolic profile of the anterior cingulate cortex in veterans with traumatic brain injury (TBI). We report significantly elevated myoinositol levels in veterans with TBI compared with those without TBI.

scholarly journals Mild Traumatic Brain Injury is Associated With Effect of Inflammation on Structural Changes of Default Mode Network in Those Developing Chronic Pain 

2020 ◽  
Author(s):  
Xuan Niu ◽  
Lijun Bai ◽  
Yingxiang Sun ◽  
Yuan Wang ◽  
Guanghui Bai ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Structural Changes ◽  
Cingulate Cortex ◽  
Pain Modulation ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
The Impact

Abstract Background：Mild traumatic brain injury (mTBI) is higher prevalence (more than 50%) to develop chronic posttraumatic headache (CPTH) compared with moderate or severe TBI. However, the underlying neural mechanism for CPTH remains unclear. This study aimed to investigate the inflammation level and cortical volume changes in patients with acute PTH (APTH) and further examine their potential in identifying patients who finally developing CPTH at follow-up.Methods：77 mTBI patients initially underwent neuropsychological measurements, 9-plex panel of serum cytokines and MRI scans within 7 days post-injury (T-1) and 54 (70.1%) of patients follow-up at 3-month (T-2). 42 matched healthy controls completed the same protocol at T-1 once. Results：MTBI patients with APTH presented significantly increased GM volume mainly in the right dorsal anterior cingulate cortex (dACC) and dorsal posterior cingulate cortex (dPCC), of which the dPCC volume can predict much worse impact of headache on patients’ lives by HIT-6 (β = 0.389, P = 0.007). Serum levels of C-C motif chemokine ligand 2 (CCL2) were also elevated in these patients, and its effect on the impact of headache on quality of life was partially mediated by the dPCC volume (mean [SE] indirect effect, 0.088 [0.0462], 95% CI, 0.01-0.164). Longitudinal analysis showed that the dACC and dPCC volumes as well as CCL2 levels persistently increased in patients developing CPTH 3 month postinjury. Conclusion：The findings suggested that structural remodelling of DMN brain regions were involved in the progression from acute to chronic PTH following mTBI, which also mediated the effect of inflammation processes on pain modulation.Trial registration: ClinicalTrial.gov ID: NCT02868684; registered 16 August 2016.

scholarly journals Mild traumatic brain injury is associated with effect of inflammation on structural changes of default mode network in those developing chronic pain

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Xuan Niu ◽  
Lijun Bai ◽  
Yingxiang Sun ◽  
Yuan Wang ◽  
Guanghui Bai ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Structural Changes ◽  
Cingulate Cortex ◽  
Pain Modulation ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
The Impact

Abstract Background Mild traumatic brain injury (mTBI) has a higher prevalence (more than 50%) of developing chronic posttraumatic headache (CPTH) compared with moderate or severe TBI. However, the underlying neural mechanism for CPTH remains unclear. This study aimed to investigate the inflammation level and cortical volume changes in patients with acute PTH (APTH) and further examine their potential in identifying patients who finally developed CPTH at follow-up. Methods Seventy-seven mTBI patients initially underwent neuropsychological measurements, 9-plex panel of serum cytokines and MRI scans within 7 days post-injury (T-1) and 54 (70.1%) of patients completed the same protocol at a 3-month follow-up (T-2). Forty-two matched healthy controls completed the same protocol at T-1 once. Results At baseline, mTBI patients with APTH presented significantly increased GM volume mainly in the right dorsal anterior cingulate cortex (dACC) and dorsal posterior cingulate cortex (dPCC), of which the dPCC volume can predict much worse impact of headache on patients’ lives by HIT-6 (β = 0.389, P = 0.007) in acute stage. Serum levels of C-C motif chemokine ligand 2 (CCL2) were also elevated in these patients, and its effect on the impact of headache on quality of life was partially mediated by the dPCC volume (mean [SE] indirect effect, 0.088 [0.0462], 95% CI, 0.01–0.164). Longitudinal analysis showed that the dACC and dPCC volumes as well as CCL2 levels had persistently increased in patients developing CPTH 3 months postinjury. Conclusion The findings suggested that structural remodelling of DMN brain regions were involved in the progression from acute to chronic PTH following mTBI, which also mediated the effect of inflammation processes on pain modulation. Trial registration ClinicalTrial.gov ID: NCT02868684; registered 16 August 2016.

scholarly journals Pivotal Role of Anterior Cingulate Cortex in Working Memory after Traumatic Brain Injury in Youth

2011 ◽  
Vol 1 ◽  
Author(s):  
Fabienne Cazalis ◽  
Talin Babikian ◽  
Christopher Giza ◽  
Sarah Copeland ◽  
David Hovda ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Working Memory ◽  
Brain Injury ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Pivotal Role

scholarly journals Mild traumatic brain injury is associated with effect of inflammation on structural changes of default mode network in those developing chronic pain 

2020 ◽  
Author(s):  
Xuan Niu ◽  
Lijun Bai ◽  
Yingxiang Sun ◽  
Yuan Wang ◽  
Guanghui Bai ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Structural Changes ◽  
Cingulate Cortex ◽  
Pain Modulation ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
The Impact

Abstract Background：Mild traumatic brain injury (mTBI) has a higher prevalence (more than 50%) of developing chronic posttraumatic headache (CPTH) compared with moderate or severe TBI. However, the underlying neural mechanism for CPTH remains unclear. This study aimed to investigate the inflammation level and cortical volume changes in patients with acute PTH (APTH) and further examine their potential in identifying patients who finally developed CPTH at follow-up.Methods：77 mTBI patients initially underwent neuropsychological measurements, 9-plex panel of serum cytokines and MRI scans within 7 days post-injury (T-1) and 54(70.1%) of patients completed the same protocol at a 3-month follow-up (T-2). 42 matched healthy controls completed the same protocol at T-1 once. Results：At baseline, mTBI patients with APTH presented significantly increased GM volume mainly in the right dorsal anterior cingulate cortex (dACC) and dorsal posterior cingulate cortex (dPCC), of which the dPCC volume can predict much worse impact of headache on patients’ lives by HIT-6 (β = 0.389, P = 0.007) in acute stage. Serum levels of C-C motif chemokine ligand 2 (CCL2) were also elevated in these patients, and its effect on the impact of headache on quality of life was partially mediated by the dPCC volume (mean [SE] indirect effect, 0.088 [0.0462], 95% CI, 0.01-0.164). Longitudinal analysis showed that the dACC and dPCC volumes as well as CCL2 levels had persistently increased in patients developing CPTH 3 months postinjury. Conclusion：The findings suggested that structural remodelling of DMN brain regions were involved in the progression from acute to chronic PTH following mTBI, which also mediated the effect of inflammation processes on pain modulation.Trial registration: ClinicalTrial.gov ID: NCT02868684; registered 16 August 2016.

scholarly journals Mild traumatic brain injury is associated with effect of inflammation on structural changes of default mode network in those developing chronic pain

2020 ◽  
Author(s):  
Xuan Niu ◽  
Lijun Bai ◽  
Yingxiang Sun ◽  
Yuan Wang ◽  
Guanghui Bai ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Structural Changes ◽  
Cingulate Cortex ◽  
Pain Modulation ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
The Impact

Abstract Background：Mild traumatic brain injury (mTBI) has a higher prevalence (more than 50%) of developing chronic posttraumatic headache (CPTH) compared with moderate or severe TBI. However, the underlying neural mechanism for CPTH remains unclear. This study aimed to investigate the inflammation level and cortical volume changes in patients with acute PTH (APTH) and further examine their potential in identifying patients who finally developed CPTH at follow-up.Methods：77 mTBI patients initially underwent neuropsychological measurements, 9-plex panel of serum cytokines and MRI scans within 7 days post-injury (T-1) and 54(70.1%) of patients completed the same protocol at a 3-month follow-up (T-2). 42 matched healthy controls completed the same protocol at T-1 once. Results：At baseline, mTBI patients with APTH presented significantly increased GM volume mainly in the right dorsal anterior cingulate cortex (dACC) and dorsal posterior cingulate cortex (dPCC), of which the dPCC volume can predict much worse impact of headache on patients’ lives by HIT-6 (β = 0.389, P = 0.007) in acute stage. Serum levels of C-C motif chemokine ligand 2 (CCL2) were also elevated in these patients, and its effect on the impact of headache on quality of life was partially mediated by the dPCC volume (mean [SE] indirect effect, 0.088 [0.0462], 95% CI, 0.01-0.164). Longitudinal analysis showed that the dACC and dPCC volumes as well as CCL2 levels had persistently increased in patients developing CPTH 3 months postinjury. Conclusion：The findings suggested that structural remodelling of DMN brain regions were involved in the progression from acute to chronic PTH following mTBI, which also mediated the effect of inflammation processes on pain modulation.Trial registration: ClinicalTrial.gov ID: NCT02868684; registered 16 August 2016.

Effects of unilateral deactivations of dorsolateral prefrontal cortex and anterior cingulate cortex on saccadic eye movements

2014 ◽  
Vol 111 (4) ◽  
pp. 787-803 ◽  
Author(s):  
Michael J. Koval ◽  
R. Matthew Hutchison ◽  
Stephen G. Lomber ◽  
Stefan Everling
Keyword(s):  
Prefrontal Cortex ◽  
Eye Movements ◽  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Saccadic Eye Movements ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Dorsolateral Prefrontal ◽  
Single Neuron Recording

The dorsolateral prefrontal cortex (dlPFC) and anterior cingulate cortex (ACC) have both been implicated in the cognitive control of saccadic eye movements by single neuron recording studies in nonhuman primates and functional imaging studies in humans, but their relative roles remain unclear. Here, we reversibly deactivated either dlPFC or ACC subregions in macaque monkeys while the animals performed randomly interleaved pro- and antisaccades. In addition, we explored the whole-brain functional connectivity of these two regions by applying a seed-based resting-state functional MRI analysis in a separate cohort of monkeys. We found that unilateral dlPFC deactivation had stronger behavioral effects on saccades than unilateral ACC deactivation, and that the dlPFC displayed stronger functional connectivity with frontoparietal areas than the ACC. We suggest that the dlPFC plays a more prominent role in the preparation of pro- and antisaccades than the ACC.

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