scholarly journals Toward a translational approach to targeting the endocannabinoid system in posttraumatic stress disorder: A critical review of preclinical research

2015 ◽  
Vol 104 ◽  
pp. 8-18 ◽  
Author(s):  
Santiago Papini ◽  
Gregory M. Sullivan ◽  
Denise A. Hien ◽  
Erel Shvil ◽  
Yuval Neria
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Critical Review ◽  
Stress Disorder ◽  
Endocannabinoid System ◽  
Preclinical Research ◽  
Translational Approach

scholarly journals Trauma exposure and posttraumatic stress disorder in adults with severe mental illness: A critical review

2011 ◽  
Vol 31 (6) ◽  
pp. 883-899 ◽  
Author(s):  
Anouk L. Grubaugh ◽  
Heidi M. Zinzow ◽  
Lisa Paul ◽  
Leonard E. Egede ◽  
B. Christopher Frueh
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Mental Illness ◽  
Severe Mental Illness ◽  
Posttraumatic Stress ◽  
Critical Review ◽  
Stress Disorder ◽  
Trauma Exposure

scholarly journals Behavioral profiling as a translational approach in an animal model of posttraumatic stress disorder

2016 ◽  
Vol 88 ◽  
pp. 139-147 ◽  
Author(s):  
Ziv Ardi ◽  
Anne Albrecht ◽  
Alon Richter-Levin ◽  
Rinki Saha ◽  
Gal Richter-Levin
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Animal Model ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Translational Approach ◽  
Behavioral Profiling

scholarly journals Neurobiological findings in posttraumatic stress disorder: a review

2000 ◽  
Vol 2 (1) ◽  
pp. 23-29 ◽  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Clinical Study ◽  
Posttraumatic Stress ◽  
Stress Responses ◽  
Stress Disorder ◽  
Scientific Interest ◽  
Preclinical Research ◽  
Future Studies ◽  
Biological Studies ◽  
Neurobiological Research

Since posttraumatic stress disorder (PTSD) was first recognized as a psychiatric disorder, it has generated a great deal of scientific interest. Recent studies on the neurobiology of PTSD provide evidence that PTSD is biologically distinct from other types of traumatic and nontraumatic stress responses. This paper reviews three important directions of neurobiological research in PTSD: noradrenergic axis changes and associated alterations in autonomic responsivity neuroendocrine changes involving the hypothalamic-pituitary-adrenocortical (HPA) axis, and neuroanatomy changes involving the hippocampus. Each section reviews the salient aspects of preclinical research on the biology of stress and their bearing on the understanding of PTSD, and summarizes prominent findings from clinical biological studies of PTSD, Tentative models that integrate current findings from the clinical study of PTSD are reviewed. To conclude, the important methodological and empirical issues that need to be addressed by future studies are indicated.

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