scholarly journals Highly sensitive DNA detection using cascade amplification strategy based on hybridization chain reaction and enzyme-induced metallization

2015 ◽  
Vol 66 ◽  
pp. 520-526 ◽  
Author(s):  
Xu Yu ◽  
Zhi-Ling Zhang ◽  
Si-Yang Zheng
Keyword(s):  
Dna Detection ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Highly Sensitive ◽  
Amplification Strategy ◽  
Cascade Amplification

scholarly journals Sensitive DNA detection using cascade amplification strategy based on conjugated polyelectrolytes and hybridization chain reaction

RSC Advances ◽  
2017 ◽  
Vol 7 (6) ◽  
pp. 3528-3533 ◽  
Author(s):  
Biqing Bao ◽  
Jin Zhu ◽  
Lina Gong ◽  
Jia Chen ◽  
Yanrui Pan ◽  
...  
Keyword(s):  
Signal Amplification ◽  
Dna Detection ◽  
Hybridization Chain Reaction ◽  
Molecular Wire ◽  
Conjugated Polyelectrolytes ◽  
Chain Reaction ◽  
Amplification Strategy ◽  
Cascade Amplification

A novel cascade amplification strategy that combines the molecular wire effects of CPEs with the signal amplification capability of the HCR has been developed for sensitive DNA detection.

Highly sensitive SERS assay of genetically modified organisms in maize via a nanoflowers substrate coupling with hybridization chain reaction amplification

2021 ◽  
Author(s):  
Xinyu Zhou ◽  
Shengjie Ge ◽  
Yue Sun ◽  
Menglin Ran ◽  
Yifan Liu ◽  
...  
Keyword(s):  
Research Methods ◽  
Dna Sequences ◽  
Genetically Modified Organisms ◽  
Dna Detection ◽  
Genetically Modified ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Substrate Coupling ◽  
Highly Sensitive ◽  
Reaction Amplification

The research methods for DNA detection have been widely extended since the application of nanotechnology, but it remains a challenge to detect specific DNA sequences or low abundance genes in...

A triple-amplification strategy based on the formation of peroxidase-like two-dimensional DNA/Fe3O4 networks initiated by the hybridization chain reaction for highly sensitive detection of microRNA

2019 ◽  
Vol 55 (58) ◽  
pp. 8386-8389 ◽  
Author(s):  
Sheng Tang ◽  
Yana Li ◽  
Anni Zhu ◽  
Yao Yao ◽  
Jun Sun ◽  
...  
Keyword(s):  
Sensitive Detection ◽  
Hybridization Chain Reaction ◽  
Two Dimensional ◽  
Chain Reaction ◽  
Highly Sensitive ◽  
Highly Sensitive Detection ◽  
Amplification Strategy

Peroxidase-like two-dimensional DNA/Fe3O4 networks were constructed by the hybridization chain reaction and applied to detect microRNA down to the aM level.

A label-free cyclic assembly of G-quadruplex nanowires for cascade amplification detection of T4 polynucleotide kinase activity and inhibition

The Analyst ◽  
2015 ◽  
Vol 140 (17) ◽  
pp. 6124-6130 ◽  
Author(s):  
Zhilu Shi ◽  
Xiafei Zhang ◽  
Rui Cheng ◽  
Baoxin Li ◽  
Yan Jin
Keyword(s):  
Kinase Activity ◽  
Hybridization Chain Reaction ◽  
Label Free ◽  
Chain Reaction ◽  
Polynucleotide Kinase ◽  
G Quadruplex ◽  
Amplification Strategy ◽  
Cascade Amplification ◽  
T4 Polynucleotide Kinase

A label-free and enzyme-free amplification strategy has been developed for sensitively and specifically studying PNK activity and inhibitionviathe hybridization chain reaction (HCR).

scholarly journals Two-color imaging of microRNA with enzyme-free signal amplification via hybridization chain reactions in living cells

2016 ◽  
Vol 7 (3) ◽  
pp. 1940-1945 ◽  
Author(s):  
Lu Li ◽  
Jie Feng ◽  
Haiyun Liu ◽  
Qingling Li ◽  
Lili Tong ◽  
...  
Keyword(s):  
Disease Diagnosis ◽  
Living Cells ◽  
Hybridization Chain Reaction ◽  
Early Disease ◽  
Chain Reaction ◽  
Chain Reactions ◽  
Simultaneous Imaging ◽  
Highly Sensitive ◽  
Amplification Strategy ◽  
Non Destructive

Here, a non-destructive amplification strategy is developed to image miRNAs in living cells, utilizing the enzyme-free hybridization chain reaction (HCR) with graphene oxide (GO) as a carrier. This provides a new tool for highly sensitive and simultaneous imaging of multiple low-level biomarkers, improving the accuracy of early disease diagnosis.

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