Pain is commonly perceived by patients during cancer and its treatment. Although most
patients respond to conservative management implemented according to the World Health
Organization guidelines, a subset of patients with advanced disease develop intractable pain
that may require additional interventions such as regional blocks and intrathecal therapy.
Patients with terminal abdominal or pelvic cancer who have high tumor burdens are often
offered a diagnostic visceral nerve block followed by neurolysis for pain palliation. Conventional
visceral blocks usually require fluoroscopic guidance for correct needle placement in the
vicinity of the neuroaxis or abdominal cavity. These techniques carry risks of injury to vessels,
bowels, and nerves. Transversus abdominis plane (TAP) block is a technique that is easy to
perform (particularly when ultrasonographic guidance is used), has a good safety record, and
effectively reduces pain levels and opioid requirements after abdominal and gynecological
surgery. Although numerous studies have demonstrated the effectiveness of TAP blocks in
acute pain management, the role of TAP block in chronic pain management is very limited. We
believe that chemical neurolysis with phenol can prolong the effects of analgesia in patients
with terminal cancer. We describe a case of terminal abdominal sarcoma with intractable
pain that responded well to a TAP block followed by TAP neurolysis. The patient tolerated the
procedure well and demonstrated sustained analgesia for 45 days before dying of the disease.
We also demonstrated that TAP block significantly reduces the total opioid requirement as
demonstrated by the morphine equivalent daily dose score after the neurolytic procedure. This
result supports our belief that TAP block with TAP neurolysis is an effective and inexpensive
modality that can be used to palliate intractable abdominal wall pain in patients with terminal
abdominal cancer.
Key words: Cancer pain management, phenol neurolysis, chemical neurolysis, transversus
abdominis plane block, cancer pain palliation, intractable abdominal pain, ultrasound guided