Lymph node dissections in cutaneous malignancy: Where are we now? A review of 10 years’ experience at a tertiary centre

2021 ◽  
Author(s):  
Oliver Jones ◽  
Suzanne H Murphy ◽  
Garance Biosse-Duplan ◽  
Animesh JK Patel ◽  
Amit Roshan ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cutaneous Malignancy ◽  
Tertiary Centre

scholarly journals Completely resected stage III melanoma controversy - 15 years of national tertiary centre experience

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Barbara Peric ◽  
Sara Milicevic ◽  
Andraz Perhavec ◽  
Marko Hocevar ◽  
Janez Zgajnar
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Rapid Development ◽  
Primary Tumour ◽  
Stage Iii ◽  
Unknown Primary ◽  
Tertiary Centre ◽  
Kaplan Meier ◽  
Stage Iii Melanoma ◽  
Resected Stage

AbstractBackgroundTwo prospective randomized studies analysing cutaneous melanoma (CM) patients with sentinel lymph node (SLN) metastases and rapid development of systemic adjuvant therapy have changed our approach to stage III CM treatment. The aim of this study was to compare results of retrospective survival analysis of stage III CM patients’ treatment from Slovenian national CM register to leading international clinical guidelines.Patients and methodsSince 2000, all Slovenian CM patients with primary tumour ≥ TIb are treated at the Institute of Oncology Ljubljana and data are prospectively collected into a national CM registry. A retrospective analysis of 2426 sentinel lymph node (SLN) biopsies and 789 lymphadenectomies performed until 2015 was conducted using Kaplan-Meier survival curves and log-rank tests.ResultsPositive SLN was found in 519/2426 (21.4%) of patients and completion dissection (CLND) was performed in 455 patients. The 5-year overall survival (OS) of CLND group was 58% vs. 47% of metachronous metastases group (MLNM) (p = 0.003). The 5-year OS of patients with lymph node (LN) metastases and unknown primary site (UPM) was 45% vs. 21% of patients with synchronous LN metastasis. Patients with SLN tumour burden < 0.3 mm had 5-year OS similar to SLN negative patients (86% vs. 85%; p = 0.926). The 5-year OS of patients with burden > 1.0 mm was similar to the MLNM group (49% vs. 47%; p = 0.280).ConclusionsStage III melanoma patients is a heterogeneous group with significant OS differences. CLND after positive SLNB might still remain a method of treatment for selected patients with stage III.

Completely Resected Stage Iii Melanoma Controversy: 15 Years Of National Tertiary Centre Experience

2020 ◽  
Author(s):  
Barbara Perić ◽  
Sara Milicevic ◽  
Andraz Perhavec ◽  
Marko Hocevar ◽  
Janez Zgajnar
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Rapid Development ◽  
Primary Tumour ◽  
Stage Iii ◽  
Unknown Primary ◽  
Complication Rates ◽  
Tertiary Centre ◽  
Kaplan Meier ◽  
Resected Stage

Abstract BACKGROUNDTwo prospective randomized studies analysing cutaneous melanoma (CM) patients with sentinel lymph node (SLN) metastases and rapid development of adjuvant therapy have changed our approach to stage III CM treatment. The aim of this study was to compare results of retrospective survival analysis of stage III CM patients’ treatment from Slovenian national CM register to current clinical guidelines.METHODSSince 2000, all Slovenian CM patients with primary tumour ≥ TIb are treated at the Institute of Oncology Ljubljana and data are prospectively collected into a national CM registry. A retrospective analysis of 2426 sentinel lymph node (SLN) biopsies and 789 lymphadenectomies performed until 2015 was conducted using Kaplan-Meier survival curves and log-rank tests.RESULTSPositive SLN was found in 519/2426 (21.4%) of patients and completion dissection (CLND) was performed in 455 patients. The 5-year overall survival (OS) of CLND group was 58% versus 47% of metachronous metastases group (MLNM) (p = 0.003). The 5-year OS of patients with lymph node (LN) metastases and unknown primary site (UPM) was 45% versus 21% of patients with synchronous LN metastasis. Patients with SLN tumour burden < 0.3 mm had 5-year OS similar to SLN negative patients (86% vs. 85%; p = 0.926). The 5-year OS of patients with burden > 1.0 mm was similar to the MLNM group (49% vs 47%; p = 0.280). CONCLUSIONStage III melanoma patients is a heterogeneous group with significant OS differences. CLND after positive SLNB might still remain a method of treatment for some of those patients if low postoperative complication rates can be reassured.

scholarly journals Clinical Impact of Unexpected Para-Aortic Lymph Node Metastasis in Surgery for Resectable Pancreatic Cancer

2021 ◽  
Author(s):  
Ho-Kyoung Lee ◽  
Yoo-Seok Yoon ◽  
Ho-Seong Han ◽  
Jun Suh Lee ◽  
Hee Young Na ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Lymph Node ◽  
Absolute Number ◽  
Prognostic Impact ◽  
Resectable Pancreatic Cancer ◽  
Regional Lymph Nodes ◽  
Tertiary Centre ◽  
Pathologic Evaluation ◽  
Aortic Lymph Node ◽  
Group B

Abstract Radiologically identified para-aortic lymph node (PALN) metastasis is contraindicated for pancreatic cancer (PC) surgery. There is no clinical consensus for unexpected intraoperative PALN. To analyse the prognostic role of unexpected PALN in resectable PC, we retrospectively reviewed data of 1,953 PC patients in a single tertiary centre. Patients with intraoperative PALN without radiological PALN (group A1, negative pathology, n = 59; group A2, positive pathology, n = 13) showed median overall survival (OS) of 24.6 (95% confidence interval [CI]: 15.2–33.2) and 13.0 (95%CI: 4.9–19.7) months, respectively. Patients with radiological PALN metastasis without other metastases (group B, n = 91) showed median OS of 8.6 months (95%CI: 7.4–11.6). Compared with group B, groups A1 and A2 had hazard ratios (HRs) of 0.37 (95%CI, 0.2–0.6) and 1.04 (95%CI: 0.7–1.4), respectively. Compared with group A2, group A1 had HR of 0.33 (95%CI: 0.2–0.7). Analysing regional lymph nodes (LNs), the positive LN ratio affected survival (HR: 2.67, 95%CI: 1.6–4.5), while the absolute number of positive LNs (HR: 1.79, 95%CI: 0.7–4.6) did not. Thus, unexpected malignant PALN has a negative prognostic impact comparable to radiological PALN metastasis. Prompt pathologic evaluation for unexpected PALN and maximal harvest of regional LNs during PC surgery are suggested.

Full-Thickness Grafts Procured from Skin Overlying the Sentinel Lymph Node Basin; Reconstruction of Primary Cutaneous Malignancy Excision Defects

2008 ◽  
Vol 15 (6) ◽  
pp. 1733-1740 ◽  
Author(s):  
James M. Lewis ◽  
Jonathan S. Zager ◽  
Daohai Yu ◽  
Diego Pelaez ◽  
Adam I. Riker ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Full Thickness ◽  
Cutaneous Malignancy

PWE-302 Colorectal cancer lymph node retrieval number is associated with biological and institutional factors: a tertiary centre audit

Gut ◽  
2015 ◽  
Vol 64 (Suppl 1) ◽  
pp. A344.1-A344
Author(s):  
CJ Deutsch ◽  
NR Hall ◽  
RJ Davies ◽  
NS Fearnhead ◽  
R Miller ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Institutional Factors ◽  
Tertiary Centre ◽  
Lymph Node Retrieval

scholarly journals Changing trends in incidence and clinical spectrum of extra-pulmonary tuberculosis: a 10-year retrospective study in a rural teaching hospital in South India

2018 ◽  
Vol 6 (1) ◽  
pp. 220
Author(s):  
Sanoop Kumar Sherin Sabu ◽  
Vergis Paul ◽  
Deepu J. E. Mathew ◽  
T. M. Jacob ◽  
Celine T. M.
Keyword(s):  
Lymph Node ◽  
Pleural Effusion ◽  
Female Gender ◽  
Clinical Spectrum ◽  
Diagnostic Tools ◽  
Annual Number ◽  
Tertiary Centre ◽  
National Trends ◽  
Rural Teaching ◽  
The Impact

Background: EPTB, remains a great mimicker in spite of availability of new diagnostic tools. The data available in different literatures and national record remain inconclusive. This study aims to find the change in incidence and clinical spectrum of EPTB during 10 years in the proposed study center.Methods: Retrospective, medical records based study, on patients newly diagnosed to have EPTB, at MOSC-MCH, Kolenchery, Kerala, India from 1-01-2006 to 31-12-2015.Results: Among the 1488 new cases of tuberculosis 665 (44.7%) had EPTB and 823 (55.3%) had pulmonary TB (PTB). There was a consistent rise in annual number of new cases of EPTB from 2007 to 2013. Lymph-node, 31% (n=203) and pleural effusion 26% (n= 126) are common sites. There was female gender predominance in the age group of 18-44 years. Commonest site of lesion in females as well as in males was lymph node TB (n=121, 35.9% and n=82, 25% respectively). Pleural effusion and genital TB showed a male predominance.Conclusions: Incidence of EPTB shows an increasing trend from 2006 to 2015 in this study which is in contrast to the falling state and national trends. In the global TB reports, India has underestimated TB data between 2000 and 2015. The rising trend of new cases in our study centre can be the impact of immigrant labourers or may be due to increased referred cases to this tertiary centre. Further multicentre studies and studies among the immigrant labourers should be done to evaluate this.

Sign in / Sign up

Export Citation Format

Share Document