scholarly journals Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1

2012 ◽  
Vol 20 (1) ◽  
pp. 487-497 ◽  
Author(s):  
Joseph J. Jablonski ◽  
Dipwanita Basu ◽  
Daniel A. Engel ◽  
H. Mario Geysen
Keyword(s):  
Influenza Virus ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Virus Protein ◽  
Design Synthesis

scholarly journals Small Molecule Inhibitors of Influenza Virus Entry

2021 ◽  
Vol 14 (6) ◽  
pp. 587
Author(s):  
Zhaoyu Chen ◽  
Qinghua Cui ◽  
Michael Caffrey ◽  
Lijun Rong ◽  
Ruikun Du
Keyword(s):  
Influenza Virus ◽  
Membrane Fusion ◽  
Small Molecule ◽  
Drug Target ◽  
Small Molecule Inhibitors ◽  
Virus Entry ◽  
Critical Role ◽  
Structural Basis ◽  
Future Directions ◽  
The Past

Hemagglutinin (HA) plays a critical role during influenza virus receptor binding and subsequent membrane fusion process, thus HA has become a promising drug target. For the past several decades, we and other researchers have discovered a series of HA inhibitors mainly targeting its fusion machinery. In this review, we summarize the advances in HA-targeted development of small molecule inhibitors. Moreover, we discuss the structural basis and mode of action of these inhibitors, and speculate upon future directions toward more potent inhibitors of membrane fusion and potential anti-influenza drugs.

scholarly journals Optimization of Small-Molecule Inhibitors of Influenza Virus Polymerase: From Thiophene-3-Carboxamide to Polyamido Scaffolds

2014 ◽  
Vol 57 (10) ◽  
pp. 4337-4350 ◽  
Author(s):  
Susan Lepri ◽  
Giulio Nannetti ◽  
Giulia Muratore ◽  
Gabriele Cruciani ◽  
Renzo Ruzziconi ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Small Molecule ◽  
Small Molecule Inhibitors

scholarly journals Design, Synthesis and Biological Evaluation of Oxindole-Based Chalcones as Small-Molecule Inhibitors of Melanogenic Tyrosinase

2017 ◽  
Vol 65 (9) ◽  
pp. 833-839 ◽  
Author(s):  
Sharad Kumar Suthar ◽  
Sumit Bansal ◽  
Niteen Narkhede ◽  
Manju Guleria ◽  
Angel Treasa Alex ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening

2011 ◽  
Vol 19 (1) ◽  
pp. 91-101 ◽  
Author(s):  
Judith M. LaLonde ◽  
Mark A. Elban ◽  
Joel R. Courter ◽  
Akihiro Sugawara ◽  
Takahiro Soeta ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Gp120 Binding ◽  
Synthesis And Biological Evaluation

Development and Challenges of HER2 Inhibitors Discovery

2020 ◽  
Vol 20 ◽  
Author(s):  
Zhi-Gang Sun ◽  
Liang-Hui Zhao ◽  
Zhi-Na Li ◽  
Hai-Liang Zhu
Keyword(s):  
Clinical Research ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Cancer Drugs ◽  
Design Synthesis ◽  
Inhibitor Development ◽  
Her Family ◽  
The World ◽  
The Future

: The treatment of cancer has always been a major problem in the world. Some cancers cannot be treated with surgery, but only with cancer drugs. Among many cancer drugs, small molecule inhibitors play an irreplaceable role. HER2 is one of the HER family, and the development of HER2 inhibitors has made a huge contribution to the treatment of cancer. Some HER2 inhibitors are already on the market, and some HER2 inhibitors are undergoing clinical research. The design, synthesis and development of new HER2 inhibitors targeting different targets are also ongoing, and some are even applying for clinical research. The HER2 inhibitors that are on the market have developed resistance, which brings great challenges to the HER2 inhibitor development in the future. This article reviews the development and challenges of HER2 inhibitors discovery.

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