Enhanced intracellular peptide delivery by multivalent cell-penetrating peptide with bioreducible linkage

2018 ◽  
Vol 28 (3) ◽  
pp. 378-381 ◽  
Author(s):  
Hyungjin Kim ◽  
Mizuki Kitamatsu ◽  
Takashi Ohtsuki
Keyword(s):  
Peptide Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

Cell-penetrating-peptide-based delivery of oligonucleotides: an overview

2007 ◽  
Vol 35 (4) ◽  
pp. 775-779 ◽  
Author(s):  
R. Abes ◽  
A.A. Arzumanov ◽  
H.M. Moulton ◽  
S. Abes ◽  
G.D. Ivanova ◽  
...  
Keyword(s):  
Cell Penetrating Peptides ◽  
Peptide Delivery ◽  
Cell Penetrating Peptide ◽  
Cellular Internalization ◽  
Structure Activity ◽  
Cell Penetrating ◽  
Transactivator Of Transcription ◽  
Endocytic Vesicles ◽  
Oligonucleotide Analogues ◽  
Phosphorodiamidate Morpholino Oligomers

Cationic CPPs (cell-penetrating peptides) have been used largely for intracellular delivery of low-molecular-mass drugs, biomolecules and particles. Most cationic CPPs bind to cell-associated glycosaminoglycans and are internalized by endocytosis, although the detailed mechanisms involved remain controversial. Sequestration and degradation in endocytic vesicles severely limits the efficiency of cytoplasmic and/or nuclear delivery of CPP-conjugated material. Re-routing the splicing machinery by using steric-block ON (oligonucleotide) analogues, such as PNAs (peptide nucleic acids) or PMOs (phosphorodiamidate morpholino oligomers), has consequently been inefficient when ONs are conjugated with standard CPPs such as Tat (transactivator of transcription), R9 (nona-arginine), K8 (octalysine) or penetratin in the absence of endosomolytic agents. New arginine-rich CPPs such as (R-Ahx-R)4 (6-aminohexanoic acid-spaced oligo-arginine) or R6 (hexa-arginine)–penetratin conjugated to PMO or PNA resulted in efficient splicing correction at non-cytotoxic doses in the absence of chloroquine. SAR (structure–activity relationship) analyses are underway to optimize these peptide delivery vectors and to understand their mechanisms of cellular internalization.

scholarly journals Evaluation of Cell Penetrating Peptide Delivery System on HPV16E7 Expression in Three Types of Cell Line

2015 ◽  
Vol 13 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Tayebeh Saleh ◽  
Azam Bolhassani ◽  
Seyed Abbas Shojaosadati ◽  
Saman Hosseinkhani
Keyword(s):  
Cell Line ◽  
Delivery System ◽  
Peptide Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

Cell-penetrating peptide delivery of biologically active oct4 protein into cultured Takifugu rubripes spermary cells

2014 ◽  
Vol 85 (5) ◽  
pp. 1369-1380 ◽  
Author(s):  
X. X. Yang ◽  
X. N. Hou ◽  
B. Xu ◽  
X. Hao ◽  
G. J. Jiang ◽  
...  
Keyword(s):  
Peptide Delivery ◽  
Biologically Active ◽  
Cell Penetrating Peptide ◽  
Takifugu Rubripes ◽  
Cell Penetrating ◽  
Oct4 Protein

scholarly journals Characterisation of cell-penetrating peptide-mediated peptide delivery

2005 ◽  
Vol 145 (8) ◽  
pp. 1093-1102 ◽  
Author(s):  
Simon W Jones ◽  
Richard Christison ◽  
Ken Bundell ◽  
Catherine J Voyce ◽  
Sarah M V Brockbank ◽  
...  
Keyword(s):  
Peptide Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

scholarly journals Designed Cell-Penetrating Peptide Inhibitors of Amyloid-beta Aggregation and Cytotoxicity

2020 ◽  
Vol 1 (2) ◽  
pp. 100014 ◽  
Author(s):  
Anja Henning-Knechtel ◽  
Sunil Kumar ◽  
Cecilia Wallin ◽  
Sylwia Król ◽  
Sebastian K.T.S. Wärmländer ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Peptide Inhibitors ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating
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