Parathyroid hormone exposure to human articular osteoarthritic chondrocytes results in collagen and proteoglycan synthesis: May parathyroid hormone be a possible anabolic treatment opportunity for osteoarthritis?

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S254
Author(s):  
B. Sondergaard ◽  
S.H. Madsen ◽  
A. Bay-Jensen ◽  
T. Christensen ◽  
C. Chrtiansen ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Proteoglycan Synthesis ◽  
Osteoarthritic Chondrocytes ◽  
Anabolic Treatment ◽  
Hormone Exposure

Bone-targeting parathyroid hormone conjugates outperform unmodified PTH in the anabolic treatment of osteoporosis in rats

2017 ◽  
Vol 7 (4) ◽  
pp. 482-496 ◽  
Author(s):  
Yang Yang ◽  
Ali Aghazadeh-Habashi ◽  
Arash Panahifar ◽  
Yuchin Wu ◽  
Krishna H. Bhandari ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Treatment Of Osteoporosis ◽  
Bone Targeting ◽  
Anabolic Treatment

scholarly journals The use of PTH in the treatment of osteoporosis

2010 ◽  
Vol 54 (2) ◽  
pp. 213-219 ◽  
Author(s):  
Victória Z. Cochenski Borba ◽  
Nádila Cecyn Pietszkowski Mañas
Keyword(s):  
Parathyroid Hormone ◽  
Bone Density ◽  
Adverse Effects ◽  
Combination Therapy ◽  
Biochemical Markers ◽  
Osteoporosis Treatment ◽  
Antiresorptive Therapy ◽  
Treatment Of Osteoporosis ◽  
Antiresorptive Agents ◽  
Anabolic Treatment

Anabolic drugs have recently widened therapeutic options in osteoporosis treatment, as they influence processes associated with bone formation to a greater extent and earlier than bone reabsortion. They positively affect a number of skeletal properties besides bone density, as intermittent administration of parathyroid hormone (PTH) results in an increase in the number and activity of osteoblasts leading to an increase in bone mass and improvement in skeletal architecture at both the trabecular and cortical bone. Human recombinant parathyroid hormone (hrPTH 1-84) and human recombinant PTH peptide 1-34 (teriparatide) belong to this group. The objective of this paper is to review PTH actions, benefits and adverse effects, action on biochemical markers, combination therapy with antiresorptive agents, impact of antiresorptive therapy prior to anabolic treatment, sequential treatment, and effect on glucocorticoid-induced osteoporosis.

scholarly journals Different duration of parathyroid hormone exposure distinctively regulates primary response genes Nurr1 and RANKL in osteoblasts

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0208514 ◽  
Author(s):  
Hyewon Choi ◽  
Clara E. Magyar ◽  
Jeanne M. Nervina ◽  
Sotirios Tetradis
Keyword(s):  
Parathyroid Hormone ◽  
Primary Response ◽  
Primary Response Genes ◽  
Hormone Exposure

miR‐873‐3p targets HDAC4 to stimulate matrix metalloproteinase‐13 expression upon parathyroid hormone exposure in rat osteoblasts

2020 ◽  
Vol 235 (11) ◽  
pp. 7996-8009 ◽  
Author(s):  
Desai Malavika ◽  
Srinivasan Shreya ◽  
Vembar Raj Priya ◽  
Muthukumar Rohini ◽  
Zhiming He ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 13 ◽  
Hormone Exposure ◽  
Rat Osteoblasts

Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: An analysis by DNA microarray

2005 ◽  
Vol 95 (2) ◽  
pp. 403-418 ◽  
Author(s):  
Jude E. Onyia ◽  
Leah M. Helvering ◽  
Lawrence Gelbert ◽  
Tao Wei ◽  
Shuguang Huang ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Dna Microarray ◽  
Molecular Profile ◽  
Treatment Regimens ◽  
Anabolic Treatment ◽  
Rat Bone
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