scholarly journals Dynamics of the KcsA Selectivity Filter Probed using Intrinsic Tyrosine Fluorescence

2015 ◽  
Vol 108 (2) ◽  
pp. 118a-119a
Author(s):  
H. Raghuraman ◽  
Eduardo Perozo
Keyword(s):  
Selectivity Filter ◽  
Tyrosine Fluorescence

Sodium ions do not stabilize the selectivity filter of a potassium channel

2021 ◽  
pp. 167091
Author(s):  
Kitty Hendriks ◽  
Carl Öster ◽  
Chaowei Shi ◽  
Han Sun ◽  
Adam Lange
Keyword(s):  
Potassium Channel ◽  
Selectivity Filter ◽  
Sodium Ions

Ion–peptide interactions between alkali metal ions and a termini-protected dipeptide: modeling a portion of the selectivity filter in K+ channels

2019 ◽  
Vol 21 (2) ◽  
pp. 561-571 ◽  
Author(s):  
Shun-ichi Ishiuchi ◽  
Yuta Sasaki ◽  
James M. Lisy ◽  
Masaaki Fujii
Keyword(s):  
Alkali Metal ◽  
Metal Ions ◽  
Selectivity Filter ◽  
Alkali Metal Ions ◽  
K Channels ◽  
Peptide Interactions

Differentiating K+ and Na+ binding patterns in peptide sequences.

scholarly journals Probing the Cavity of the Slow Inactivated Conformation of Shaker Potassium Channels

2007 ◽  
Vol 129 (5) ◽  
pp. 403-418 ◽  
Author(s):  
Gyorgy Panyi ◽  
Carol Deutsch
Keyword(s):  
Potassium Channels ◽  
Binding Site ◽  
Conformational Change ◽  
Marked Decrease ◽  
Selectivity Filter ◽  
Slow Inactivation ◽  
Voltage Gated ◽  
Activation Gate ◽  
Shaker Potassium Channels

Slow inactivation involves a local rearrangement of the outer mouth of voltage-gated potassium channels, but nothing is known regarding rearrangements in the cavity between the activation gate and the selectivity filter. We now report that the cavity undergoes a conformational change in the slow-inactivated state. This change is manifest as altered accessibility of residues facing the aqueous cavity and as a marked decrease in the affinity of tetraethylammonium for its internal binding site. These findings have implications for global alterations of the channel during slow inactivation and putative coupling between activation and slow-inactivation gates.

Personalized treatment with retigabine for pharmacoresistant epilepsy arising from a pathogenic variant in the KCNQ2 selectivity filter

2021 ◽  
Vol 23 (5) ◽  
pp. 695-705
Author(s):  
Andreea Nissenkorn ◽  
Polina Kornilov ◽  
Asher Peretz ◽  
Lubov Blumkin ◽  
Gali Heimer ◽  
...  
Keyword(s):  
Pathogenic Variant ◽  
Selectivity Filter ◽  
Personalized Treatment ◽  
Pharmacoresistant Epilepsy

scholarly journals The selectivity filter of a ligand-gated ion channel

FEBS Letters ◽  
1989 ◽  
Vol 257 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Ferdinand Hucho ◽  
Rolf Hilgenfeld
Keyword(s):  
Ion Channel ◽  
Selectivity Filter

A mutation affecting symbiosis in the pea line Risnod27 changes the ion selectivity filter of the DMI1 homolog

2009 ◽  
Vol 53 (3) ◽  
pp. 451-460 ◽  
Author(s):  
K. Novak ◽  
J. Felsberg ◽  
E. Biedermannova ◽  
J. Vondrys
Keyword(s):  
Ion Selectivity ◽  
Selectivity Filter
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