scholarly journals Polymeric Effects vs. Chemical Specificity -- Effects of Hyaluronic Acid on Lung Surfactant Monolayers

2018 ◽  
Vol 114 (3) ◽  
pp. 561a
Author(s):  
Benjamin R. Slaw ◽  
Ka Yee C. Lee
Keyword(s):  
Hyaluronic Acid ◽  
Lung Surfactant ◽  
Surfactant Monolayers ◽  
Specificity Effects

scholarly journals Effect of Hyaluronic Acid on the Differentiation of Mesenchymal Stem Cells into Mature Type II Pneumocytes

Polymers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 2928
Author(s):  
Francesca Della Sala ◽  
Mario di Gennaro ◽  
Gianluca Lista ◽  
Francesco Messina ◽  
Luigi Ambrosio ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Lung Surfactant ◽  
Repair Process ◽  
Surfactant Protein ◽  
Alveolar Type ◽  
Type Ii ◽  
Type Ii Pneumocytes ◽  
Mature Type ◽  
Pulmonary Damage ◽  
Msc Differentiation

Hyaluronic acid (HA) is an essential component of the extracellular matrix (ECM) of the healthy lung, playing an important role in the structure of the alveolar surface stabilizing the surfactant proteins. Alveolar type II (ATII) cells are the fundamental element of the alveolus, specializing in surfactant production. ATII cells represent the main target of lung external lesion and a cornerstone in the repair process of pulmonary damage. In this context, knowledge of the factors influencing mesenchymal stem cell (MSC) differentiation in ATII cells is pivotal in fulfilling therapeutic strategies based on MSCs in lung regenerative medicine. To achieve this goal, the role of HA in promoting the differentiation of MSCs in mature Type II pneumocytes capable of secreting pulmonary surfactant was evaluated. Results demonstrated that HA, at a specific molecular weight can greatly increase the expression of lung surfactant protein, indicating the ability of HA to influence MSC differentiation in ATII cells.

scholarly journals The role of SP-B1–25 peptides in lung surfactant monolayers exposed to gold nanoparticles

2020 ◽  
Vol 22 (27) ◽  
pp. 15231-15241
Author(s):  
Sheikh I. Hossain ◽  
Neha S. Gandhi ◽  
Zak E. Hughes ◽  
Suvash C. Saha
Keyword(s):  
Gold Nanoparticles ◽  
Lung Surfactant ◽  
Breathing Cycle ◽  
First Line ◽  
Surfactant Monolayers ◽  
Inhaled Nanoparticles

Lung surfactant monolayer’s (acts as the first line barrier for inhaled nanoparticles) components (lipids and peptides) rearrange themselves by the influence of exposed gold nanoparticles at various stages of the breathing cycle.

The model of the action mechanism of SP-C in the lung surfactant monolayers

2007 ◽  
Vol 57 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Dan Li ◽  
Zuoxiang Zeng ◽  
Weilan Xue ◽  
Yali Yao
Keyword(s):  
Lung Surfactant ◽  
Action Mechanism ◽  
Surfactant Monolayers

Nanostructure Changes in Lung Surfactant Monolayers Induced by Interactions between Palmitoyloleoylphosphatidylglycerol and Surfactant Protein B†

Langmuir ◽  
2003 ◽  
Vol 19 (5) ◽  
pp. 1539-1550 ◽  
Author(s):  
Junqi Ding ◽  
Ivo Doudevski ◽  
Heidi E. Warriner ◽  
Timothy Alig ◽  
Joseph A. Zasadzinski ◽  
...  
Keyword(s):  
Lung Surfactant ◽  
Surfactant Protein ◽  
Surfactant Monolayers ◽  
Surfactant Protein B ◽  
Protein B
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