A Macro-Micro Modeling Approach to Determine In-Situ Heart Valve Interstitial Cell Contractile Behaviors in Native and Synthetic Environments

We reveal a sharp transition from smooth muscle to interstitial cell of Cajal (ICC)-driven motility in the chicken embryo, leading to higher-frequency, more rhythmic contractile waves. We predict the transition to happen between 12 and 14 embryonic wk in humans. We image for the first time the onset of ICC activity in an embryonic gut by calcium imaging. We show the first KIT and anoctamin-1 (ANO1) in situ hybridization micrographs in the embryonic chicken gut.

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Multi-scale Modeling of the Heart Valve Interstitial Cell

Multi-scale Extracellular Matrix Mechanics and Mechanobiology - Studies in Mechanobiology, Tissue Engineering and Biomaterials ◽

10.1007/978-3-030-20182-1_2 ◽

2019 ◽

pp. 21-53

Author(s):

Alex Khang ◽

Daniel P. Howsmon ◽

Emma Lejeune ◽

Michael S. Sacks

Keyword(s):

Heart Valve ◽

Interstitial Cell ◽

Multi Scale ◽

Scale Modeling ◽

Multi Scale Modeling

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Detailed micro-modeling approach and solution strategy for laterally loaded reinforced masonry shear walls

Engineering Structures ◽

10.1016/j.engstruct.2019.109786 ◽

2019 ◽

Vol 201 ◽

pp. 109786 ◽

Cited By ~ 1

Author(s):

Sebastián Calderón ◽

Oriol Arnau ◽

Cristián Sandoval

Keyword(s):

Shear Walls ◽

Solution Strategy ◽

Modeling Approach ◽

Reinforced Masonry ◽

Micro Modeling ◽

Laterally Loaded

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A MULTISCALE MODELING AND X-RAY CT EXPLORATION OF BEARING FAILURE MECHANISMS IN A COUNTERSUNK BOLTED COMPOSITE STRUCTURE

10.12783/asc36/35879 ◽

2021 ◽

Author(s):

XIAODONG CUI ◽

JIAN XIAO ◽

JIM LUA ◽

SUPUN KARIYAWASAM ◽

ETHAN FULGHUM ◽

...

Keyword(s):

Damage Mechanics ◽

Continuum Damage Mechanics ◽

Matrix Cracking ◽

Bearing Failure ◽

X Ray ◽

Failure Patterns ◽

Modeling Approach ◽

X Ray Computed ◽

Bolt Diameter

To investigate the failure mechanism in composite bolted joints, an in-situ X-Ray computed tomography (XCT) technique was developed and single shear bearing (SSB) tests were performed with quasi-isotropic layup. High-fidelity XCT was explored for the detection and characterization of bearing failure in bolted composite components without removing the fastener. A novel load frame was also introduced for in-situ XCT scan and a preliminary scan was performed. A micro-macro coupling modeling approach was proposed on the basis of continuum damage mechanics (CDM) method and a static bearing model, which was based on micromechanics analysis to consider the residual stress after fiber kinking and matrix cracking under compression in the bearing region. The SSB specimens were modified using a larger bolt diameter to avoid bolt failure and achieve extensive bearing failure. The developed modeling approach was verified using SSB test data by comparing the predicted load displacement response with experimental measurement and the failure patterns obtained from XCT scanning images.

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