Ubiquitin and ubiquitin-conjugated protein expression in the rat cerebral cortex and hippocampus following traumatic brain injury (TBI)

2007 ◽  
Vol 1182 ◽  
pp. 116-122 ◽  
Author(s):  
Xianglan Yao ◽  
Jiong Liu ◽  
Joseph T. McCabe
Keyword(s):  
Traumatic Brain Injury ◽  
Cerebral Cortex ◽  
Brain Injury ◽  
Protein Expression ◽  
Rat Cerebral Cortex

Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury

2009 ◽  
Vol 1284 ◽  
pp. 191-201 ◽  
Author(s):  
Ping Lei ◽  
Yaohua Li ◽  
Xin Chen ◽  
Shuyuan Yang ◽  
Jianning Zhang
Keyword(s):  
Traumatic Brain Injury ◽  
Cerebral Cortex ◽  
Brain Injury ◽  
Microrna Expression ◽  
Rat Cerebral Cortex

Isolation of neural stem cells from damaged rat cerebral cortex after traumatic brain injury

Neuroreport ◽  
2005 ◽  
Vol 16 (15) ◽  
pp. 1687-1691 ◽  
Author(s):  
Tatsuki Itoh ◽  
Takao Satou ◽  
Shigeo Hashimoto ◽  
Hiroyuki Ito
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Cerebral Cortex ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Rat Cerebral Cortex

Traumatic brain injury-induced acute gene expression changes in rat cerebral cortex identified by GeneChip analysis

2002 ◽  
Vol 71 (2) ◽  
pp. 208-219 ◽  
Author(s):  
Vemuganti L. Raghavendra Rao ◽  
Vinay K. Dhodda ◽  
Guoqing Song ◽  
Kellie K. Bowen ◽  
Robert J. Dempsey
Keyword(s):  
Gene Expression ◽  
Traumatic Brain Injury ◽  
Cerebral Cortex ◽  
Brain Injury ◽  
Rat Cerebral Cortex ◽  
Genechip Analysis

scholarly journals Diurnal variation of NMDA receptor expression in the rat cerebral cortex is associated with traumatic brain injury damage

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Francisco Estrada-Rojo ◽  
Julio Morales-Gomez ◽  
Elvia Coballase-Urrutia ◽  
Marina Martinez-Vargas ◽  
Luz Navarro
Keyword(s):  
Traumatic Brain Injury ◽  
Cerebral Cortex ◽  
Brain Injury ◽  
Nmda Receptor ◽  
Diurnal Variation ◽  
Receptor Expression ◽  
Rat Cerebral Cortex

Cullin 5 gene expression in the rat cerebral cortex and hippocampus following traumatic brain injury (TBI)

2006 ◽  
Vol 409 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Xiang-Lan Yao ◽  
Jiong Liu ◽  
Eleanor Lee ◽  
Geoffrey S.F. Ling ◽  
Joseph T. McCabe
Keyword(s):  
Gene Expression ◽  
Traumatic Brain Injury ◽  
Cerebral Cortex ◽  
Brain Injury ◽  
Rat Cerebral Cortex ◽  
Cullin 5

Protective effects of icariin on traumatic brain injury

2021 ◽  
Vol 19 ◽  
Author(s):  
Anni Du ◽  
Rui Cai ◽  
Jingshan Shi ◽  
Qin Wu
Keyword(s):  
Traumatic Brain Injury ◽  
Cerebral Cortex ◽  
Brain Injury ◽  
Protein Expression ◽  
Chinese Herb ◽  
Inflammatory Factors ◽  
Therapeutic Drug ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Expression Levels

Background: Neuroinflammation is central to the pathology of traumatic brain injury (TBI). Icariin (ICA) is a flavonoid derived from the genus Epimedium which is a traditional Chinese herb, a potential therapeutic drug for TBI. This study aims to explore the protective effect of ICA on TBI and its mechanism Methods: Sprague-Dawley rats were exposed to controlled cortical impact to produce a neuroinflammatory response. The treatment groups received ICA (15 mg/kg, 30 mg/kg and 60 mg/kg), while the sham group was gavaged with equal volumes of saline. The beam-balance testing and prehensile traction test were used for neurological scoring. Pathological changes were observed by H&E staining. The protein expression levels of inflammatory factors were measured by Western blot analysis Results: It was found that ICA significantly improved the neuroethology function and alleviated the pathological injury in TBI rats. The protein expression levels of inflammatory factors COX-2, IL-1β, and TNF-α and its regulatory proteins p-NF-κB-p65, p-ERK1/2, p-JNK, and p-p38 were increased in the cerebral cortex injured by TBI. The protein expression levels of inflammatory cytokines were markedly decreased in cerebral cortex of TBI rats when administrated with ICA. Conclusion: The present study demonstrates that ICA may be a promising therapeutic strategy for reducing inflammation in TBI.

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