scholarly journals Regulation of group I metabotropic glutamate receptor expression in the rat striatum and prefrontal cortex in response to amphetamine in vivo

2010 ◽  
Vol 1326 ◽  
pp. 184-192 ◽  
Author(s):  
Christopher Shaffer ◽  
Ming-Lei Guo ◽  
Eugene E. Fibuch ◽  
Li-Min Mao ◽  
John Q. Wang
Keyword(s):  
Prefrontal Cortex ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Expression ◽  
Rat Striatum ◽  
Metabotropic Glutamate ◽  
Group I

Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists

2002 ◽  
Vol 330 (2) ◽  
pp. 127-130 ◽  
Author(s):  
Ann E Kingston ◽  
Kelly Griffey ◽  
Michael P Johnson ◽  
Mary-Jo Chamberlain ◽  
Gerald Kelly ◽  
...  
Keyword(s):  
Amino Acid ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Metabotropic Glutamate ◽  
Group I ◽  
Amino Acid Antagonists ◽  
New Generation

scholarly journals Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction

2015 ◽  
Vol 112 (4) ◽  
pp. 1196-1201 ◽  
Author(s):  
Adam G. Walker ◽  
Cody J. Wenthur ◽  
Zixiu Xiang ◽  
Jerri M. Rook ◽  
Kyle A. Emmitte ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Fear Extinction ◽  
Long Term Depression ◽  
Metabotropic Glutamate ◽  
Metabotropic Glutamate Receptor 3

Clinical studies have revealed that genetic variations in metabotropic glutamate receptor 3 (mGlu3) affect performance on cognitive tasks dependent upon the prefrontal cortex (PFC) and may be linked to psychiatric conditions such as schizophrenia, bipolar disorder, and addiction. We have performed a series of studies aimed at understanding how mGlu3 influences PFC function and cognitive behaviors. In the present study, we found that activation of mGlu3 can induce long-term depression in the mouse medial PFC (mPFC) in vitro. Furthermore, in vivo administration of a selective mGlu3 negative allosteric modulator impaired learning in the mPFC-dependent fear extinction task. The results of these studies implicate mGlu3 as a major regulator of PFC function and cognition. Additionally, potentiators of mGlu3 may be useful in alleviating prefrontal impairments associated with several CNS disorders.

scholarly journals In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands

2004 ◽  
Vol 88 (5) ◽  
pp. 1068-1077 ◽  
Author(s):  
Ilse Smolders ◽  
Hilde Lindekens ◽  
Ralph Clinckers ◽  
Alfred Meurs ◽  
Michael J. O'Neill ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Ligands ◽  
Limbic Seizures ◽  
Metabotropic Glutamate ◽  
Group I

scholarly journals Acute administration of cocaine reduces metabotropic glutamate receptor 8 protein expression in the rat striatum in vivo

2009 ◽  
Vol 449 (3) ◽  
pp. 224-227 ◽  
Author(s):  
Guo-Chi Zhang ◽  
Khang Vu ◽  
Nikhil K. Parelkar ◽  
Li-Min Mao ◽  
Ian M. Stanford ◽  
...  
Keyword(s):  
Protein Expression ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Rat Striatum ◽  
Acute Administration ◽  
Metabotropic Glutamate

Group I and II metabotropic glutamate receptor expression in cultured rat spinal cord astrocytes

1999 ◽  
Vol 263 (2-3) ◽  
pp. 117-120 ◽  
Author(s):  
G.A Silva ◽  
E Theriault ◽  
L.R Mills ◽  
P.S Pennefather ◽  
C.J Feeney
Keyword(s):  
Spinal Cord ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Expression ◽  
Rat Spinal Cord ◽  
Metabotropic Glutamate ◽  
Group I
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