Differential effects of NMDA and AMPA/kainate receptor antagonists on superoxide production and MnSOD activity in rat brain following intrahippocampal injection

This is a notice of retraction of the article: Effect of 7-nitroindazole on superoxide production and MnSOD activity in the rat brain following kainate-induced neurotoxicity, published in the Archives of Biological Sciences in 2008, Vol. 60, Issue 1. The Editor-in-Chief has been informed that this paper plagiarizes an earlier paper: Radenovic L, Selakovic V, Kartelija G, Todorovic N, Nedeljkovic M. Differential effects of NMDA and AMPA/kainate receptor antagonists on superoxide production and MnSOD activity in rat brain following intrahippocampal injection. Brain Res Bull, 2004, 64(1):85-93. The results in the article being retracted were presented as findings obtained from novel research. Inspection of the results has revealed that they were part of research already presented in the original article without appropriate justification or cross-referencing. The Editor-in-Chief considered publishing a notice of redundancy specifying the elements published previously. However, since the original article had already been autoplagiarized by the same corresponding author in the same journal (retraction DOI:10.2298/ABS150318026E), the article is being retracted in accordance with the publishing ethics of the Archives of Biological Sciences in order to preserve the integrity of scientific research. We apologize to the journal's readers that it took so long to notice this error and instigate retraction of the paper. We request our readers to contact the editorial office and editors of the journal directly should similar cases occur in the future, so that the necessary action can be taken more promptly. Link to the retracted article <a href="http://dx.doi.org/10.2298/ABS0801025R">10.2298/ABS0801025R</a>

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Differential effects of NMDA and AMPA/kainate receptor antagonists on nitric oxide production in rat brain following intrahippocampal injection

Brain Research Bulletin ◽

10.1016/j.brainresbull.2005.06.019 ◽

2005 ◽

Vol 67 (1-2) ◽

pp. 133-141 ◽

Cited By ~ 22

Author(s):

L. Radenovic ◽

V. Selakovic

Keyword(s):

Nitric Oxide ◽

Rat Brain ◽

Kainate Receptor ◽

Nitric Oxide Production ◽

Receptor Antagonists ◽

Differential Effects ◽

Oxide Production ◽

Intrahippocampal Injection

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Retraction: Radenovic L, Selakovic V. Mitochondrial superoxide production and MnSOD activity following exposure to an agonist and antagonists of ionotropic receptors in rat brain, Arch Biol Sci. 2005; 57(1):1-10, DOI:10.2298/ABS0501001R

Archives of Biological Sciences ◽

10.2298/abs150318026e ◽

2015 ◽

Vol 67 (2) ◽

pp. 741-741

Author(s):

E Editorial

Keyword(s):

Biological Sciences ◽

Rat Brain ◽

Superoxide Production ◽

Ionotropic Glutamate Receptors ◽

Editorial Office ◽

Mitochondrial Superoxide ◽

Retracted Article ◽

Intrahippocampal Injection ◽

Mnsod Activity ◽

Font Color

This is a notice of retraction of the article: Mitochondrial superoxide production and MnSOD activity following exposure to an agonist and antagonists of ionotropic glutamate receptors in rat brain, published in the Archives of Biological Sciences in 2005, Vol. 57, Issue 1. The Editor-in-Chief has been informed that this paper plagiarizes an earlier paper: Radenovic L, Selakovic V, Kartelija G, Todorovic N, Nedeljkovic M. Differential effects of NMDA and AMPA/kainate receptor antagonists on superoxide production and MnSOD activity in rat brain following intrahippocampal injection. Brain Res Bull, 2004, 64(1):85-93. This claim is correct and almost the entire paper is a verbatim copy of the earlier one. After confirmation of this fact, the Editor-in-Chief of the Archives of Biological Sciences has decided to retract the paper immediately. We apologize to the readers of the journal that it took so many years to notice this error and to retract the paper. We request readers of the journal to directly get in touch with the editorial office and the editors of the journal for similar cases in the future, so that they can be handled promptly. Link to the retracted article <a href="http://dx.doi.org/10.2298/ABS0501001R">10.2298/ABS0501001R</a>

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Mitochondrial superoxide production and MnSOD activity following exposure to an agonist and antagonists of ionotropic receptors in rat brain

Archives of Biological Sciences ◽

10.2298/abs0501001r ◽

2005 ◽

Vol 57 (1) ◽

pp. 1-10

Author(s):

Lidija Radenovic ◽

Vesna Selakovic

Keyword(s):

Nmda Receptor ◽

Receptor Antagonist ◽

Rat Brain ◽

Nmda Receptor Antagonist ◽

Superoxide Production ◽

Kainate Receptors ◽

Glutamate Antagonists ◽

Time Dynamics ◽

Mitochondrial Superoxide ◽

Intrahippocampal Injection

The involvement of NMDA and AMPA/kainate receptors in the induction of superoxide production in the rat brain was examined after intrahippocampal injection of kainate, a non-NMDA receptor agonist; kainate plus CNQX, a selective AMPA/kainate receptor antagonist; or kainate plus APV, a selective NMDA receptor antagonist. The measurements took place at different times in the ipsi- and contralateral hippocampus, forebrain cortex, striatum, and cerebellum homogenates. The used glutamate antagonists both ensured sufficient neuroprotection in the sense of lowering superoxide production and raising MnSOD levels, but in the mechanisms and time dynamics of their effects were different. Our findings suggest that NMDA and AMPA/kainate receptors are differentially involved in superoxide production. This article has been retracted. Link to the retraction <a href="http://dx.doi.org/10.2298/ABS150318026E">10.2298/ABS150318026E</a>

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Kainate-induced oxidative stress and neurotoxicity in the rat brain

Archives of Biological Sciences ◽

10.2298/abs0504259r ◽

2005 ◽

Vol 57 (4) ◽

pp. 259-266 ◽

Cited By ~ 2

Author(s):

Lidija Radenovic ◽

Vesna Selakovic

Keyword(s):

Oxidative Stress ◽

Free Radicals ◽

Rat Brain ◽

Neuronal Cells ◽

Brain Regions ◽

Superoxide Production ◽

Rat Hippocampus ◽

Protective Mechanism ◽

Mnsod Activity ◽

Font Color

We investigated superoxide production and MnSOD activity after kainate injection into the CA3 region of the rat hippocampus. The measurements took place at different times in hippocampus, forebrain cortex, striatum, and cerebellum homogenates. Free radicals including superoxide are responsible for post-lesional cytotoxicity. Neuronal cells responded to oxidative stress in kainate-induced neurotoxicity and caused the protective mechanism to increase MnSOD levels. The increase of MnSOD in distinct brain regions functionally connected via afferents and efferent suggests that these regions are affected by the injury. It implies that MnSOD protects the cells in these regions from superoxide-induced damage and therefore may limit the retrograde and anterograde spread of neurotoxicity. This article has been retracted. Link to the retraction <a href="http://dx.doi.org/10.2298/ABS150318027E">10.2298/ABS150318027E</a>

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Use of Both Fluoro-Jade B and Hematoxylin and Eosin to Detect Cell Death in the Juvenile Rat Brain Exposed to NMDA-Receptor Antagonists or GABA-Receptor Agonists in Safety Assessment

Toxicologic Pathology ◽

10.1177/01926233211007735 ◽

2021 ◽

pp. 019262332110077

Author(s):

Catherine A. Picut ◽

Odete R. Mendes ◽

David S. Weil ◽

Sarah Davis ◽

Cynthia Swanson

Keyword(s):

Cell Death ◽

Nmda Receptor ◽

Rat Brain ◽

Neuronal Cell Death ◽

Neuronal Cell ◽

Nmda Receptor Antagonists ◽

Neonatal Rats ◽

Receptor Antagonists ◽

Fluoro Jade B ◽

Hematoxylin And Eosin

Administration of pediatric anesthetics with N-methyl D-aspartate (NMDA)-receptor antagonist and/or γ-aminobutyric acid (GABA) agonist activities may result in neuronal degeneration and/or neuronal cell death in neonatal rats. Evaluating pediatric drug candidates for this potential neurotoxicity is often part of overall preclinical new drug development strategy. This specialized assessment may require dosing neonatal rats at postnatal day 7 at the peak of the brain growth spurt and evaluating brain tissue 24 to 48 hours following dosing. The need to identify methods to aid in the accurate and reproducible detection of lesions associated with this type of neurotoxic profile is paramount for meeting the changing needs of neuropathology assessment and addressing emerging challenges in the neuroscience field. We document the use of Fluoro-Jade B (FJB) staining, to be used in conjunction with standard hematoxylin and eosin staining, to detect acute neurodegeneration and neuronal cell death that can be caused by some NMDA-receptor antagonists and/or GABA agonists in the neonatal rat brain. The FJB staining is simple, specific, and sensitive and can be performed on brain specimens from the same cohort of animals utilized for standard neurotoxicity assessment, thus satisfying animal welfare recommendations with no effect on achievement of scientific and regulatory goals.

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