Long-term effects of selective immunolesions of cholinergic neurons of the nucleus basalis magnocellularis on the ascending cholinergic pathways in the rat: A model for Alzheimer's disease

Emotional well-being is an important aspect of health for individuals with Alzheimer's disease, and self-esteem, depression, and life satisfaction have been identified as factors that comprise emotional well-being. As individuals undergo physical and psychological change associated with aging process, they tend to review their lives to achieve a sense of well-being in an effort to compensate for loss due to aging process. It evidences in the literature that the life review program (LRP) is an effective therapeutic recreation intervention to increase emotional well-being of elders with Alzheimer’s disease. With 17 Korean elders with Alzheimer’s disease, the findings of the current study showed some significant effects on Korean elderly with Alzheimer's disease in their emotional well-being. Although long-term effects of the LRP were questionable, the LRP was effective to make a therapeutic change in emotional well-being of Korean elderly with Alzheimer's disease.

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Long term effects of hrt on Alzheimer's disease

International Journal of Gynecology & Obstetrics ◽

10.1016/s0020-7292(00)86127-5 ◽

2000 ◽

Vol 70 ◽

pp. B16-B16

Author(s):

H. Honio ◽

N. Kikuchi ◽

Y. Kinoshita ◽

T. Hosoda ◽

K. Kariya ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Long Term Effects

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Atrophy of Basal Forebrain Initiates with Tau Pathology in Individuals at Risk for Alzheimer’s Disease

Cerebral Cortex ◽

10.1093/cercor/bhz224 ◽

2019 ◽

Vol 30 (4) ◽

pp. 2083-2098

Author(s):

Jose L Cantero ◽

Mercedes Atienza ◽

Carmen Lage ◽

Laszlo Zaborszky ◽

Eduard Vilaplana ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

At Risk ◽

Basal Forebrain ◽

Cholinergic Neurons ◽

Nucleus Basalis ◽

Tau Pathology ◽

Projection System ◽

Prodromal Ad

Abstract Evidence suggests that the basal forebrain (BF) cholinergic system degenerates early in the course of Alzheimer’s disease (AD), likely due to the vulnerability of BF cholinergic neurons to tau pathology. However, it remains unclear whether the presence of tauopathy is the only requirement for initiating the BF degeneration in asymptomatic subjects at risk for AD (AR-AD), and how BF structural deficits evolve from normal aging to preclinical and prodromal AD. Here, we provide human in vivo magnetic resonance imaging evidence supporting that abnormal cerebrospinal fluid levels of phosphorylated tau (T+) are selectively associated with bilateral volume loss of the nucleus basalis of Meynert (nbM, Ch4) in AR-AD individuals. Spreading of atrophy to medial septum and vertical limb of diagonal band Broca (Ch1–Ch2) occurred in both preclinical and prodromal AD. With the exception of A+, all groups revealed significant correlations between volume reduction of BF cholinergic compartments and atrophy of their innervated regions. Overall, these results support the central role played by tauopathy in instigating the nbM degeneration in AR-AD individuals and the necessary coexistence of both AD proteinopathies for spreading damage to larger BF territories, thus affecting the core of the BF cholinergic projection system.

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