A role of Na+, K+ -ATPase in spatial memory deficits and inflammatory/oxidative stress after recurrent concussion in adolescent rats

ABSTRACTMethamphetamine (METH) is frequently abused drug and produces cognitive deficits. METH could induce hyper-glutamatergic state in the brain, which could partially explain METH-related cognitive deficits, but the synaptic etiology remains incompletely understood. To address this issue, we explored the role of dCA1 tripartite synapses and the potential therapeutic effects of electro-acupuncture (EA) in the development of METH withdrawal-induced spatial memory deficits in mice. We found that METH withdrawal weakened astrocytic capacity of glutamate (Glu) uptake, but failed to change Glu release from dCA3, which lead to hyper-glutamatergic excitotoxicity at dCA1 tripartite synapses. By restoring the astrocytic capacity of Glu uptake, EA treatments suppressed the hyper-glutamatergic state and normalized the excitability of postsynaptic neuron in dCA1, finally alleviated spatial memory deficits in METH withdrawal mice. These findings indicate that astrocyte at tripartite synapses might be a key target for developing therapeutic interventions against METH-associated cognitive disorders, and EA represent a promising non-invasive therapeutic strategy for the management of drugs-caused neurotoxicity.

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NEUROPROTECTIVE EFFECT OF WATERMELON (CITRULLUS LANATUS) PULP JUICE ON SCOPOLAMINE-INDUCED MEMORY DEFICITS IN SWISS ALBINO MICE: THE ROLE OF ACETYLCHOLINESTERASE AND OXIDATIVE STRESS

International Journal of Research in Ayurveda and Pharmacy ◽

10.7897/2277-4343.120373 ◽

2021 ◽

Vol 12 (3) ◽

pp. 52-56

Author(s):

Divya N ◽

Amudha P ◽

Viveka K Priya

Keyword(s):

Oxidative Stress ◽

Ache Activity ◽

Citrullus Lanatus ◽

Neuroprotective Effect ◽

Memory Deficits ◽

Memory Deficit ◽

Stress Indicators ◽

Oxidative Stress Indicators ◽

And Oxidative Stress

The effect of Watermelon (Citrullus lanatus) Pulp Juice (WPJ) on scopolamine (SCOP) induced memory deficits is due to the involvement of oxidative stress and AChE activity. The juice was obtained by crushing the pulp in blender and three different concentrations of 100%, 50% and 25% was administration to prevent memory deficit by evaluating changes of AChE activity and oxidative stress indicators (SOD, CAT, LPO and GPx) induced by scopolamine. These results provide evidence that WPJ is an alternative to protect SCOP induced memory deficits in mice by involvement of oxidative stress and AChE activity.

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Memory deficits and oxidative stress in cerebral ischemia–reperfusion: Neuroprotective role of physical exercise and green tea supplementation

Neurobiology of Learning and Memory ◽

10.1016/j.nlm.2014.07.005 ◽

2014 ◽

Vol 114 ◽

pp. 242-250 ◽

Cited By ~ 36

Author(s):

Helen L. Schimidt ◽

Aline Vieira ◽

Caroline Altermann ◽

Alexandre Martins ◽

Priscila Sosa ◽

...

Keyword(s):

Oxidative Stress ◽

Cerebral Ischemia ◽

Physical Exercise ◽

Green Tea ◽

Ischemia Reperfusion ◽

Memory Deficits ◽

Cerebral Ischemia Reperfusion ◽

And Oxidative Stress

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The temporal origin of dentate granule neurons dictates their role in spatial memory

Molecular Psychiatry ◽

10.1038/s41380-021-01276-x ◽

2021 ◽

Author(s):

Nuria Masachs ◽

Vanessa Charrier ◽

Fanny Farrugia ◽

Valerie Lemaire ◽

Nicolas Blin ◽

...

Keyword(s):

Spatial Memory ◽

Neuronal Activity ◽

Functional Imaging ◽

Brain Regions ◽

Sensitive Period ◽

Granule Neurons ◽

Memory Processing ◽

Adolescent Rats ◽

Time Point

AbstractThe dentate gyrus is one of the only brain regions that continues its development after birth in rodents. Adolescence is a very sensitive period during which cognitive competences are programmed. We investigated the role of dentate granule neurons (DGNs) born during adolescence in spatial memory and compared them with those generated earlier in life (in embryos or neonates) or during adulthood by combining functional imaging, retroviral and optogenetic tools to tag and silence DGNs. By imaging DGNs expressing Zif268, a proxy for neuronal activity, we found that neurons generated in adolescent rats (and not embryos or neonates) are transiently involved in spatial memory processing. In contrast, adult-generated DGNs are recruited at a later time point when animals are older. A causal relationship between the temporal origin of DGNs and spatial memory was confirmed by silencing DGNs in behaving animals. Our results demonstrate that the emergence of spatial memory depends on neurons born during adolescence, a function later assumed by neurons generated during adulthood.

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Bergenia ciliata ameliorates streptozotocin-induced spatial memory deficits through dual cholinesterase inhibition and attenuation of oxidative stress in rats

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2018.03.115 ◽

2018 ◽

Vol 102 ◽

pp. 966-980 ◽

Cited By ~ 7

Author(s):

Priyal Barai ◽

Nisith Raval ◽

Sanjeev Acharya ◽

Niyati Acharya

Keyword(s):

Oxidative Stress ◽

Spatial Memory ◽

Memory Deficits ◽

Cholinesterase Inhibition

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Neuroprotective effect of red quinoa seeds extract on scopolamine-induced declarative memory deficits in mice: The role of acetylcholinesterase and oxidative stress

Journal of Functional Foods ◽

10.1016/j.jff.2020.103958 ◽

2020 ◽

Vol 69 ◽

pp. 103958 ◽

Cited By ~ 1

Author(s):

Sirlei Patricia Souza ◽

Andreine Aline Roos ◽

Amanda Leitão Gindri ◽

Vanessa Oliveira Domingues ◽

Jociani Ascari ◽

...

Keyword(s):

Oxidative Stress ◽

Declarative Memory ◽

Neuroprotective Effect ◽

Memory Deficits ◽

And Oxidative Stress

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Kainic acid lesion-induced spatial memory deficits of rats

Open Life Sciences ◽

10.2478/s11535-009-0001-9 ◽

2009 ◽

Vol 4 (2) ◽

pp. 179-185 ◽

Cited By ~ 6

Author(s):

Lucian Hritcu ◽

Toshitaka Nabeshima

Keyword(s):

Spatial Memory ◽

Kainic Acid ◽

Memory Performance ◽

Memory Deficits ◽

Reference Memory ◽

Maze Task ◽

Y Maze ◽

Processing And Storage ◽

And Storage

AbstractThe effects of lesioning the ventral tegmental area (VTA) or substantia nigra (SN) neurons by means of bilateral stereotaxic microinjections of kainic acid (KA) (0.4 mM) were investigated to clarify the role of the VTA and the SN neurons in learning and memory processes. The present study demonstrates that KA in the SN and the VTA lesioned rats significantly decreased spontaneous alternation in Y-maze task, working memory and reference memory in radial 8 arm-maze task, suggesting effects on spatial memory performance. Our findings provide further support for the role of the VTA and the SN neurons in processing and storage of information.

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