scholarly journals Is weight gain really a catalyst for broader recovery?: The impact of weight gain on psychological symptoms in the treatment of adolescent anorexia nervosa

2014 ◽  
Vol 56 ◽  
pp. 1-6 ◽  
Author(s):  
Erin C. Accurso ◽  
Anna C. Ciao ◽  
Ellen E. Fitzsimmons-Craft ◽  
James D. Lock ◽  
Daniel Le Grange
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Marie-Christin Bendix ◽  
Michael Stephan ◽  
Mariel Nöhre ◽  
Wally Wünsch-Leiteritz ◽  
Hagen Schmidt ◽  
...  

AbstractClinical observations show that patients with anorexia nervosa (AN) are surprisingly free from infectious diseases. There is evidence from studies in Drosophila melanogaster that starvation leads to an increased expression of antimicrobial peptides (AMPs). AMPs are part of the innate immune system and protect human surfaces from colonization with pathogenic bacteria, viruses and fungi. We compared the expression of AMPs between patients with AN and healthy controls (HC) and investigated the influence of weight gain. Using a standardized skin rinsing method, quantitative determination of the AMPs psoriasin and RNase 7 was carried out by ELISA. Even though non-significant, effect sizes revealed slightly higher AMP concentrations in HC. After a mean weight gain of 2.0 body mass index points, the concentration of psoriasin on the forehead of patients with AN increased significantly. We could not confirm our hypotheses of higher AMP concentrations in patients with AN that decrease after weight gain. On the contrary, weight gain seems to be associated with increasing AMP concentrations.


1997 ◽  
Vol 19 (1) ◽  
pp. 20-33 ◽  
Author(s):  
Susan J. Bradley ◽  
Margot J. Taylor ◽  
Joanne F. Rovet ◽  
Eudice Goldberg ◽  
Jane Hood ◽  
...  

2001 ◽  
Vol 10 (1) ◽  
pp. 22-40 ◽  
Author(s):  
Barbara Lay ◽  
Christine Jennen-Steinmetz ◽  
Iris Reinhard ◽  
Martin H. Schmidt

2017 ◽  
Vol 50 (4) ◽  
pp. 447-450 ◽  
Author(s):  
Guido K. W. Frank ◽  
Megan E. Shott ◽  
Jennifer O. Hagman ◽  
Marissa A. Schiel ◽  
Marisa C. DeGuzman ◽  
...  

2019 ◽  
Vol 85 (10) ◽  
pp. S236-S237
Author(s):  
Jessica Baker ◽  
Lauren Blake ◽  
Laura Thornton ◽  
Rachel Guerra ◽  
Christopher Hubel ◽  
...  

2017 ◽  
Vol 174 (6) ◽  
pp. 557-565 ◽  
Author(s):  
Marisa DeGuzman ◽  
Megan E. Shott ◽  
Tony T. Yang ◽  
Justin Riederer ◽  
Guido K.W. Frank

2019 ◽  
Vol 46 (1) ◽  
Author(s):  
Athena Milios

Anorexia Nervosa (AN) is a serious psychiatric disorder, characterized by restriction of energy intake, low body weight, intense fear of weight gain, and a disturbance in body weight self-perception. Severe and Enduring AN (SE-AN) is a long-lasting (typically 5-7 or more years and marked by several unsuccessful treatment attempts) form of AN. Traditional treatments, centering on weight restoration and core eating pathology, may be part of the reason rates of treatment dropout are high and long-term outcomes are poor, particularly in SE-AN. For SE-AN patients, who have a past marked by failed traditional treatment attempts, multidimensional treatments, addressing motivation to change and maladaptive traits, may improve a range of patient outcomes outside of eating-related symptoms, such as quality of life and interpersonal functioning.The objective of this narrative review is to briefly examine motivation-related factors (e.g., hope and readiness to change), experiential avoidance, perfectionism, and obsessive-compulsiveness, and the impact of treatment approaches incorporating these individual characteristics on various patient outcomes. In conclusion, a holistic, multidimensional, person-centred recovery approach that accounts for (a) illness severity/ chronicity, (b) individual traits, and (c) motivational factors (with a secondary focus on weight gain/eating pathology), could improve quality of life outcomes, particularly in SE-AN. Additionally, integrating patient perspectives, insights, and values into developing/testing novel person-centred interventions is paramount in order to holistically address the underlying biopsychosocial causes and perpetuating factors of AN, and to better understand the trajectory of chronicity.


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