scholarly journals Miniature ultrasound ring array transducers for transcranial ultrasound neuromodulation of freely-moving small animals

2019 ◽  
Vol 12 (2) ◽  
pp. 251-255 ◽  
Author(s):  
Hyunggug Kim ◽  
Seongyeon Kim ◽  
Nam Suk Sim ◽  
Cristina Pasquinelli ◽  
Axel Thielscher ◽  
...  
Keyword(s):  
Transcranial Ultrasound ◽  
Small Animals ◽  
Freely Moving

Wearable transcranial ultrasound system for remote stimulation of freely moving animal

2020 ◽  
pp. 1-1
Author(s):  
Evgenii Kim ◽  
Eloise Anguluan ◽  
Jeungeun Kum ◽  
Jorge Sanchez-Casanova ◽  
Tae Young Park ◽  
...  
Keyword(s):  
Transcranial Ultrasound ◽  
Freely Moving ◽  
Ultrasound System ◽  
Stimulation Of

FUS-mediated Neuromodulation from Unanesthetized Freely-moving Animals

2018 ◽  
Author(s):  
Wonhye Lee ◽  
Seung-Schik Yoo
Keyword(s):  
Success Rate ◽  
Safety Profile ◽  
Focused Ultrasound ◽  
Behavioral Responses ◽  
Small Animals ◽  
Electrophysiological Signals ◽  
Freely Moving ◽  
Behavioral Monitoring ◽  
Transcranial Focused Ultrasound ◽  
Immunohistological Analysis

The goal of the proposed research is to implement and apply non-thermal transcranial focused ultrasound (FUS) to the somatomotor area (SM1) of unanesthetized, freely- moving, awake small animals (rats). We will examine the neuromodulatory outcome based on electrophysiological signals and motor behavioral responses to the sonication. The safety profile of the sonication will also be evaluated through immunohistological analysis and behavioral monitoring. The investigation of FUS neuromodulatory effects in awake animals will be essential for assessing the success rate and reproducibility of stimulation, without the confounding effects of anesthesia.

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