The development of burn scar contractures and their impact on joint function, disability and quality of life in low- and middle-income countries: a prospective cohort study with one-year follow-up

IntroductionSurvivors of acute pancreatitis (AP) have shorter overall survival and increased incidence of new-onset cardiovascular, respiratory, liver and renal disease, diabetes mellitus and cancer compared with the general population, but the mechanisms that explain this are yet to be elucidated. Our aim is to characterise the precise nature and extent of organ dysfunction following an episode of AP.Methods and analysisThis is an observational prospective cohort study in a single centre comprising a University hospital with an acute and emergency receiving unit and clinical research facility. Participants will be adult patient admitted with AP. Participants will undergo assessment at recruitment, 3 months and 3 years. At each time point, multiple biochemical and/or physiological assessments to measure cardiovascular, respiratory, liver, renal and cognitive function, diabetes mellitus and quality of life. Recruitment was from 30 November 2017 to 31 May 2020; last follow-up measurements is due on 31 May 2023. The primary outcome measure is the incidence of new-onset type 3c diabetes mellitus during follow-up. Secondary outcome measures include: quality of life analyses (SF-36, Gastrointestinal Quality of Life Index); montreal cognitive assessment; organ system physiological performance; multiomics predictors of AP severity, detection of premature cellular senescence. In a nested cohort within the main cohort, individuals may also consent to multiparameter MRI scan, echocardiography, pulmonary function testing, cardiopulmonary exercise testing and pulse-wave analysis.Ethics and disseminationThis study has received the following approvals: UK IRAS Number 178615; South-east Scotland Research Ethics Committee number 16/SS/0065. Results will be made available to AP survivors, caregivers, funders and other researchers. Publications will be open-access.Trial registration numbersClinicalTrials.gov Registry (NCT03342716) and ISRCTN50581876; Pre-results.

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Quality of life one year post-Shiga toxin-producingEscherichia coliO104 infection - A prospective cohort study

Neurogastroenterology & Motility ◽

10.1111/nmo.12503 ◽

2015 ◽

Vol 27 (3) ◽

pp. 370-378 ◽

Cited By ~ 4

Author(s):

B. Riegel ◽

W. Broicher ◽

K. Wegscheider ◽

V. Andresen ◽

E. Brähler ◽

...

Keyword(s):

Quality Of Life ◽

Cohort Study ◽

Prospective Cohort Study ◽

Shiga Toxin ◽

Prospective Cohort ◽

One Year

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Protocol for a prospective cohort study of open tibia fractures in Malawi with a nested implementation of open fracture guidelines

Wellcome Open Research ◽

10.12688/wellcomeopenres.17145.1 ◽

2021 ◽

Vol 6 ◽

pp. 228

Author(s):

Alexander Thomas Schade ◽

Nohakhelha Nyamulani ◽

Leonard Ngoe Banza ◽

Andrew John Metcalfe ◽

Andrew Leather ◽

...

Keyword(s):

Quality Of Life ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Open Fracture ◽

Open Fractures ◽

Fracture Management ◽

Tibia Fractures ◽

One Year

Background: Road traffic injury (RTI) is the largest cause of death amongst 15–39-year-old people worldwide, and the burden of injuries such as open tibia fractures are rapidly increasing in Malawi. This study aims to investigate disability and economic outcomes of people with open tibia fractures in Malawi and improve these with locally delivered implementation of open fracture guidelines. Methods: This is a prospective cohort study describing function, quality of life and economic burden of open tibia fractures in Malawi. In total, 160 participants will be recruited across six centres and will be followed-up with face-to-face interviews at six weeks, three months, six months and one year following injury. The primary outcome will be function at one year measured by the short musculoskeletal functional assessment (SMFA) score. Secondary outcomes will include quality of life measured by EuroQol EQ-5D-3L, catastrophic loss of income and implementation outcomes (acceptability, adoption, appropriateness, costs, feasibility, fidelity, penetration, and sustainability) at one year. A nested pilot pre-post implementation study of an interventional bundle for all open fractures will be developed based on other implementation studies from low- and middle-income countries (LMICs). Regression analysis will be used to model and investigate associations between SMFA score and fracture severity, infection and the pre- and post-training course period. Outcome: This prospective cohort study will report patient reported outcomes from open tibia fractures in low-resource settings. Subsequent detailed evaluation of both the clinical and implementation components of the study will promote sustainability of improved open fractures management in the study sites and further scale-up of open fracture management guidelines. Ethics: Ethics approval has been obtained from the Liverpool School of Tropical Medicine and College of Medicine Research and Ethics committee.

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