Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO

2012 ◽  
Vol 318 (2) ◽  
pp. 154-161 ◽  
Author(s):  
Tuanjie Li ◽  
Yang Yang ◽  
Xuefeng Hua ◽  
Guoying Wang ◽  
Wei Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nk Cell ◽  
Cell Dysfunction ◽  
Carcinoma Associated Fibroblasts

scholarly journals IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction

2018 ◽  
Vol 9 ◽  
Author(s):  
Nicholas J. W. Easom ◽  
Kerstin A. Stegmann ◽  
Leo Swadling ◽  
Laura J. Pallett ◽  
Alice R. Burton ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nk Cell ◽  
Cell Dysfunction

scholarly journals Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy

2015 ◽  
Vol 36 (10) ◽  
pp. 1191-1199 ◽  
Author(s):  
Cheng Sun ◽  
Hao-yu Sun ◽  
Wei-hua Xiao ◽  
Cai Zhang ◽  
Zhi-gang Tian
Keyword(s):  
Hepatocellular Carcinoma ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Nk Cell ◽  
Killer Cell ◽  
Cell Dysfunction

scholarly journals Natural Killer Cell Dysfunction in Hepatocellular Carcinoma: Pathogenesis and Clinical Implications

2018 ◽  
Author(s):  
Pil Soo Sung ◽  
Jeong Won Jang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nk Cells ◽  
Natural Killer ◽  
Cell Function ◽  
Nk Cell ◽  
Critical Role ◽  
Killer Cell ◽  
Cell Therapies ◽  
Cell Dysfunction ◽  
Cell Functions

Hepatocellular carcinoma (HCC) is currently the third leading cause of malignancy-related mortalities worldwide. Natural killer (NK) cells are involved in the critical role of first line immunological defense against cancer development. Defects in NK cell functions are recognized as important mechanisms for immune evasion of tumor cells. NK cell function appears to be attenuated in HCC, and many previous reports suggested that NK cells play a critical role in controlling HCC, suggesting that boosting the activity of dysfunctional NK cells can enhance tumor cell killing. However, the detailed mechanisms of NK cell dysfunction in tumor microenvironment of HCC remain largely unknown. A better understanding of the mechanisms of NK cell dysfunction in HCC will help in the NK cell-mediated eradication of cancer cells and prolong patient survival. In this review, we describe the various mechanisms underlying NK cell dysfunction in HCC. Further, we summarize current advances in the approaches to enhance endogenous NK cell function and in adoptive NK cell therapies, to cure this difficult-to-treat cancer.

NK-cell dysfunction in hepatocellular carcinoma: modulatory approches for functional restoration

2020 ◽  
Vol 73 ◽  
pp. S629
Author(s):  
Alessandra Zecca ◽  
Valeria Barili ◽  
Raffaelle Dalla Valle ◽  
Danila Rizzo ◽  
Andrea Olivani ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nk Cell ◽  
Functional Restoration ◽  
Cell Dysfunction

scholarly journals Natural Killer Cell Dysfunction in Hepatocellular Carcinoma: Pathogenesis and Clinical Implications

2018 ◽  
Vol 19 (11) ◽  
pp. 3648 ◽  
Author(s):  
Pil Soo Sung ◽  
Jeong Won Jang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nk Cells ◽  
Natural Killer ◽  
Cell Function ◽  
Nk Cell ◽  
Critical Role ◽  
Killer Cell ◽  
Cell Therapies ◽  
Cell Dysfunction ◽  
Cell Functions

Hepatocellular carcinoma (HCC) is currently the third leading cause of malignancy-related mortalities worldwide. Natural killer (NK) cells are involved in the critical role of first line immunological defense against cancer development. Defects in NK cell functions are recognized as important mechanisms for immune evasion of tumor cells. NK cell function appears to be attenuated in HCC, and many previous reports suggested that NK cells play a critical role in controlling HCC, suggesting that boosting the activity of dysfunctional NK cells can enhance tumor cell killing. However, the detailed mechanisms of NK cell dysfunction in tumor microenvironment of HCC remain largely unknown. A better understanding of the mechanisms of NK cell dysfunction in HCC will help in the NK cell-mediated eradication of cancer cells and prolong patient survival. In this review, we describe the various mechanisms underlying human NK cell dysfunction in HCC. Further, we summarize current advances in the approaches to enhance endogenous NK cell function and in adoptive NK cell therapies, to cure this difficult-to-treat cancer.

Tumor derived exsomes mediate tumor infiltrating NK-cell dysfunction in patients with hepatocellular carcinoma via TGF-β/SMAD pathway

2017 ◽  
Vol 66 (1) ◽  
pp. S77 ◽  
Author(s):  
Q.-F. Zhang ◽  
W.-W. Yin ◽  
Q. Liu ◽  
Y.-L. Li ◽  
M.-H. Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nk Cell ◽  
Smad Pathway ◽  
Cell Dysfunction

scholarly journals Reduced Siglec‐7 expression on NK cells predicts NK cell dysfunction in primary hepatocellular carcinoma

2020 ◽  
Vol 201 (2) ◽  
pp. 161-170 ◽  
Author(s):  
L. Tao ◽  
S. Wang ◽  
L. Yang ◽  
L. Jiang ◽  
J. Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nk Cells ◽  
Nk Cell ◽  
Primary Hepatocellular Carcinoma ◽  
Cell Dysfunction

scholarly journals Immunosurveillance of Cancer and Viral Infections with Regard to Alterations of Human NK Cells Originating from Lifestyle and Aging

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 557
Author(s):  
Xuewen Deng ◽  
Hiroshi Terunuma ◽  
Mie Nieda
Keyword(s):  
Nk Cells ◽  
Viral Infections ◽  
Nk Cell ◽  
Healthy Lifestyle ◽  
Cell Activity ◽  
Nk Cell Activity ◽  
Effector Cells ◽  
Cell Dysfunction ◽  
Forest Bathing ◽  
Infected Cells

Natural killer (NK) cells are cytotoxic immune cells with an innate capacity for eliminating cancer cells and virus- infected cells. NK cells are critical effector cells in the immunosurveillance of cancer and viral infections. Patients with low NK cell activity or NK cell deficiencies are predisposed to increased risks of cancer and severe viral infections. However, functional alterations of human NK cells are associated with lifestyles and aging. Personal lifestyles, such as cigarette smoking, alcohol consumption, stress, obesity, and aging are correlated with NK cell dysfunction, whereas adequate sleep, moderate exercise, forest bathing, and listening to music are associated with functional healthy NK cells. Therefore, adherence to a healthy lifestyle is essential and will be favorable for immunosurveillance of cancer and viral infections with healthy NK cells.

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