Expression of concern: “Tyrosine phosphatase inhibitors combined with retinoic acid can enhance differentiation of neuroblastoma cells and trigger ERK- and AKT-dependent, p53-independent senescence” Cancer Letters, Volume 328, Issue 1, 1 January 2013, Pages 44-54

Background: Protein tyrosine phosphatases 1B are considered to be a desirable validated target for therapeutic development of type II diabetes and obesity. Methods: A new series of imidazolyl flavonoids as potential protein tyrosine phosphatase inhibitors were synthesized and evaluated. Results: Bioactive results indicated that some synthesized compounds exhibited potent protein phosphatase 1B (PTP1B) inhibitory activities at the micromolar range. Especially, compound 8b showed the best inhibitory activity (IC50=1.0 µM) with 15-fold selectivity for PTP1B over the closely related T-cell protein tyrosine phosphatase (TCPTP). Cell viability assays indicated that 8b is cell permeable with lower cytotoxicity. Molecular modeling and dynamics studies revealed the reason for selectivity of PTP1B over TCPTP. Quantum chemical studies were carried out on these compounds to understand the structural features essential for activity. Conclusion: Compound 8b should be a potential selective PTP1B inhibitor.

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The impact of retinoic acid treatment on the sensitivity of neuroblastoma cells to fenretinide

Oncology Reports ◽

10.3892/or.2011.1479 ◽

2011 ◽

Author(s):

Gareth Veal

Keyword(s):

Retinoic Acid ◽

Acid Treatment ◽

Neuroblastoma Cells ◽

Retinoic Acid Treatment ◽

The Impact

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Parallel synthesis of a library of bidentate protein tyrosine phosphatase inhibitors based on the $alpha;-ketoacid motif*1

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(04)00263-9 ◽

2004 ◽

Vol 12 (12) ◽

pp. 3289-3298

Author(s):

Y CHEN

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Parallel Synthesis ◽

Phosphatase Inhibitors ◽

Protein Tyrosine

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Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: Potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2007.06.048 ◽

2008 ◽

Vol 16 (17) ◽

pp. 8301-8313 ◽

Cited By ~ 30

Author(s):

Mohamed Sayed Gomaa ◽

Jane L. Armstrong ◽

Beatrice Bobillon ◽

Gareth J. Veal ◽

Andrea Brancale ◽

...

Keyword(s):

Retinoic Acid ◽

Neuroblastoma Cells ◽

Trans Retinoic Acid ◽

All Trans Retinoic Acid

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Retinoic acid regulation of mu opioid receptor and c-fos mRNAs and AP-1 DNA binding in SH-SY5Y neuroblastoma cells

Molecular Brain Research ◽

10.1016/s0169-328x(01)00343-6 ◽

2002 ◽

Vol 99 (1) ◽

pp. 34-39 ◽

Cited By ~ 18

Author(s):

Shirzad Jenab ◽

Charles E Inturrisi

Keyword(s):

Retinoic Acid ◽

Dna Binding ◽

Opioid Receptor ◽

Neuroblastoma Cells ◽

Mu Opioid Receptor ◽

Mu Opioid

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Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation.

Molecular and Cellular Biology ◽

10.1128/mcb.8.4.1677 ◽

1988 ◽

Vol 8 (4) ◽

pp. 1677-1683 ◽

Cited By ~ 54

Author(s):

C J Thiele ◽

P S Cohen ◽

M A Israel

Keyword(s):

Retinoic Acid ◽

Fetal Development ◽

Neuroblastoma Cell ◽

Neuroblastoma Cells ◽

Human Neuroblastoma Cell ◽

Human Neuroblastoma Cells ◽

Human Neuroblastoma ◽

Hematopoietic Lineage ◽

Specific Manner ◽

Neuroblastoma Cell Lines

We detected expression of the c-myb proto-oncogene, which was initially thought to be expressed in a tissue-specific manner in cells of hematopoietic lineage, in human tissues of neuronal origin. Since the level of c-myb expression declined during fetal development, we studied the regulation of its expression in human neuroblastoma cell lines induced to differentiate by retinoic acid. The expression of c-myb declined during the maturation of neuroblastoma cells, and this change was mediated by a decrease in c-myb transcription.

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